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研究業績（見市文香）

原著論文

  1. Mi-ichi F*, Tsugawa H, Vo T, Kurizaki Y, Yoshida H, Arita M. Characterization of Entamoeba fatty acid elongases; validation as targets and provision of promising leads for new drugs against amebiasis. PLoS Pathogens. 20(8):e1012435. 2024. (Corresponding author)
  2. Mi-Ichi F*, Tsugawa H, Yoshida H, Arita M*. Unique features of Entamoeba histolytica glycerophospholipid metabolism; has the E. histolytica lipid metabolism network evolved through gene loss and gain to enable parasitic life cycle adaptation? mSphere. 8(5):e0017423. 2023. (*Corresponding authors)
  3. Mi-Ichi F*, Tsugawa H, Arita M, Yoshida H. Pleiotropic Roles of Cholesteryl Sulfate during Entamoeba Encystation: Involvement in Cell Rounding and Development of Membrane Impermeability. mSphere. 7(4):e0029922. 2022.(Corresponding author)
  4. Mi-ichi F*, Sakaguchi M, Hamano S, Yoshida H. Entamoeba Chitinase is Required for Mature Round Cyst Formation. Microbiol Spectr. 9(1):e0051121. 2021.(Corresponding author)
  5. Mi-ichi F*, Ikeda K, Tsugawa H, Deloer S, Yoshida H, Arita M*. Stage-specific de novo synthesis of very long chain dihydroceramides confers dormancy to Entamoeba parasites. mSphere. 6(2):e00174-21. 2021. (*Corresponding authors)
  6. Mousa EAA#, Sakaguchi M#, Nakamura R, Abdella OH, Yoshida H, Hamano S*, Mi-Ichi F*. The dynamics of ultrastructural changes during Entamoeba invadens encystation. Parasitology. 147(12):1305-1312.2020. (#Equally contributed to this article) (*Corresponding authors)
  7. Shinjyo N, Nakayama H, Ishimaru K, Hikosaka K, Mi-ichi F, Norose K, Yoshida H. Hypericum erectum alcoholic extract inhibits Toxoplasma growth and Entamoeba encystation: an exploratory study on the anti-protozoan potential. J Nat Med. 74(1):294-305. 2020．
  8. Mi-ichi F*#, Ishikawa T#, Tam VK, Deloer S, Hamano S, Hamada T, and Yoshida H. Characterization of Entamoeba histolytica adenosine 5′-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis. PLoS Negl Trop Dis. 13(8):e0007633. 2019. (#Equally contributed to this article) (Corresponding author)
  9. Mi-ichi F*, Miyake Y, Tam VK, Yoshida H. A Flow Cytometry Method for Dissecting the Cell Differentiation Process of Entamoeba Encystation. Front Cell Infect Microbiol. 8: 250. 2018 (Corresponding author)
  10. Tong H, Miyake Y, Mi-ichi F, Iwakura Y, Hara H, Yoshida H. Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells. PLoS One. 13(3), e0195119. 2018
  11. Mi-ichi F*, Miyamoto T, Yoshida H. Uniqueness of Entamoeba sulfur metabolism: sulfolipid metabolism that plays pleiotropic roles in the parasitic life cycle. Mol Microbiol. 106(3): 479-491. 2017 (Corresponding author)
  12. Santos HJ, Imai K, Hanadate Y, Fukasawa Y, Oda T, Mi-ichi F, Nozaki T. Screening and discovery of lineage-specific mitosomal membrane proteins in Entamoeba histolytica. Mol Biochem Parasitol. 209(1-2), 10-17. 2016
  13. Mi-ichi F#, Nozawa A#, Yoshida H, Tozawa Y, Nozaki T. Evidence that Entamoeba histolytica mitochondrial carrier family links mitosomal and cytosolic pathways through exchange of PAPS and ATP. Eukaryot Cell. 14(11): 1144-1150. 2015 (#Equally contributed to this article)
  14. Mi-ichi F, Miyamoto T, Takao S, Jeelani G, Hashimoto T, Hara H, Nozaki T, Yoshida H. Entamoeba mitosomes play an important role in encystation by association with cholesteryl sulfate synthesis. Proc Natl Acad Sci USA. 112(22): E2884-2890. 2015 (*Corresponding authors)
  15. Siregar JE, Kurisu G, Kobayashi T, Matsuzaki M, Sakamoto K, Mi-ichi F, Watanabe Y, Hirai M, Matsuoka H, Syafruddin D, Marzuki S, Kita K. Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex. Parasitol Int. 64(3): 295-300. 2015
  16. Yasukawa S, Miyazaki Y, Yoshii C, Nakaya M, Ozaki N, Toda S, Kuroda E, Ishibashi K, Yasuda T, Natsuaki Y, Mi-ichi F, Iizasa E, Nakahara T, Yamazaki M, Kabashima K, Iwakura Y, Takai T, Saito T, Kurosaki T, Malissen B, Ohno N, Furue M, Yoshida H, Hara H. An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. Nat Commun. 5: 3755. 2014
  17. Makiuchi T, Mi-ichi F, Nakada-Tsukui K, Nozaki T. Novel TPR-containing subunit of TOM complex functions as cytosolic receptor for Entamoeba mitosomal transport. Sci Rep. 3: 1129. 2013
  18. Mi-ichi F, Makiuchi T, Furukawa A, Sato D, Nozaki T. Sulfate Activation in Mitosomes Plays an Important Role in the Proliferation of Entamoeba histolytica. PLoS Negl Trop Dis. 5(8): e1263. 2011
  19. Husain A, Sato D, Jeelani G, Mi-ichi F, Ali V, Suematsu M, Soga T, Nozaki T. Metabolome analysis revealed increase in S-methylcysteine andphosphatidylisopropanolamine synthesis upon L-cysteine deprivation in theanaerobic protozoan parasite Entamoeba histolytica. J Biol Chem. 285(50): 39160-70. 2010
  20. Yousuf MA, Mi-ichi F, Nakada-Tsukui K, Nozaki T. Localization and targeting of an unusual pyridine nucleotide transhydrogenase in Entamoeba histolytica. Eukaryot Cell. 9(6): 926-33. 2010
  21. Mi-ichi F, Abu Yousuf M, Nakada-Tsukui K, Nozaki T. Mitosomes in Entamoeba histolytica contain a sulfate activation pathway. Proc Natl Acad Sci USA. 106(51): 21731-6. 2009
  22. Mi-ichi F, Kano S, Mitamura T. Oleic acid is indispensable for intraerythrocytic proliferation of Plasmodium falciparum. Parasitology. 134(Pt 12): 1671-7. 2007
  23. Kobayashi T, Sato S, Takamiya S, Komaki-Yasuda K, Yano K, Hirata A, Onitsuka I, Hata M, Mi-ichi F, Tanaka T, Hase T, Miyajima A, Kawazu S, Watanabe Y, Kita K. Mitochondria and apicoplast of Plasmodium falciparum: behaviour on subcellular fractionation and the implication. Mitochondrion. 7(1-2): 125-32. 2007
  24. Mi-ichi F, Kita K, Mitamura T. Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth. Parasitology. 133(Pt 4): 399-410. 2006
  25. Mi-ichi F, Miyadera H, Kobayashi T, Takamiya S, Waki S, Iwata S, Shibata S, Kita K. Parasite mitochondria as a target of chemotherapy: inhibitory effect of licochalcone A on the Plasmodium falciparum respiratory chain. Ann NY Acad Sci. 1056: 46-54. 2005
  26. Yuasa K, Mi-ichi F, Kobayashi T, Yamanouchi M, Kotera J, Kita K, Omori K. PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum. Biochem J. 392(Pt 1): 221-9. 2005
  27. Palacpac NM, Hiramine Y, Mi-ichi F, Torii M, Kita K, Hiramatsu R, Horii T, Mitamura T. Developmental-stage-specific triacylglycerol biosynthesis, degradation and trafficking as lipid bodies in Plasmodium falciparum-infected erythrocytes. J Cell Sci. 117(Pt 8): 1469-80. 2004
  28. Takashima E, Takamiya S, Takeo S, Mi-ichi F, Amino H, Kita K. Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration. Parasitol Int. 50(4): 273-8. 2001
    <総説>
  29. Mi-ichi F*, Hamano S, Yoshida H. Links between cholesteryl sulfate-dependent and -independent processes in the morphological and physiological changes of Entamoeba encystation. Parasitol Int. 99:102844. 2024 (Corresponding author)
  30. Mi-ichi F*, Yoshida H. Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation. Int J Mol Sci. 20(19). pii: E4679. 2019. Review. (Corresponding author)
  31. Mi-ichi F*, Yoshida H, Hamano S. Entamoeba encystation: new targets to prevent the transmission of amebiasis. PLoS Pathogens. 12(10): e1005845. 2016 (Corresponding author)
  32. Deloer S, Nakamura R, Mi-ichi F, Adachi K, Kobayashi S, Hamano S. Mouse models of amoebiasis and culture methods of amoeba. Parasitol Int. 65(5 Pt B): 520–525. 2016
  33. Mi-ichi F, Takeo S, Takashima E, Kobayashi T, Kim HS, Wataya Y, Matsuda A, Torii M, Tsuboi T, Kita K. Unique properties of respiratory chain in Plasmodium falciparum mitochondria. Adv Exp Med Biol. 531:117-33. 2003
  34. 中村梨沙, 見市文香, Sharmina Deloer, 濱野真二郎.「特集Ⅰ 寄生虫感染と生体防御・免疫系」. アメーバ赤痢、臨床免疫・アレルギー科. 65: 412-418. 2016
    <著書>
  35. 見市文香.（2019）脂質代謝と寄生適応戦略－赤痢アメーバの硫酸代謝の特殊性. 医学のあゆみVol.269 No.13. 1229-1236頁. （分担執筆）
  36. Makiuchi T, Mi-ichi F, Nozaki T. Mitosomes in Entamoeba histolytica. Amebiasis 2015. 305-327. 2015
  37. 見市文香, 野崎智義.赤痢アメーバマイトソームの精製方法. 寄生虫学研究 材料と方法 2013年版 85-88頁. 2013

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