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研究テーマ
１．マラリア感染における防御免疫の成立
２．熱帯熱マラリアの再燃の原因
３．ガメトサイトキャリヤーの検出
４．人獣共通感染症サルマラリアのヒトとサルでの感染ダイナミクス
JSPSアジア・アフリカ学術基盤形成事業
(H23-25)
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業績
主要な原著論文
 Kawai S, Sato M, Kato-Hayashi N, Kishi H, Huffman MA, Maeno Y, Culleton R, Nakazawa S. Detection of Plasmodium knowlesi DNA in the urine and faeces of a Japanese macaque (Macaca fuscata) over the course of an experimentally induced infection. Malaria J 13:373 (2014/09) [Abstract]
Abkallo HM, Liu W, Hokama S, Ferreira PE, Nakazawa S, Maeno Y, Quang NT, Kobayashi N, Kaneko O, Huffman MA, Kawai S, Marchand RP, Carter R, Hahn BH, Culleton R. DNA from pre-erythrocytic stage malaria parasites is detectable by PCR in the faeces and blood of hosts. Int J Parasitol 44(7):467-73 (2014/06) [Abstract]
Miao M, Wang Z, Yang Z, Yuan L, Parker DM, Putaporntip C, Jongwutiwes S, Xangsayarath P, Pongvongsa T, Moji H, Dinh Tuong T, Abe T, Nakazawa S, Kyaw MP, Yan G, Sirichaisinthop J, Sattabongkot J, Mu J, Su XZ, Kaneko O, Cui L. Genetic Diversity and Lack of Artemisinin Selection Signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion. PLoS ONE 8(3):e59192.(2013) [Abstract]
Xangsayarath P, Kaewthamasorn K, Yahata K, Nakazawa S, Sattabongkot J, Udomsangpetch R, Kaneko O. Positive diversifying selection on the Plasmodium falciparum surf4.1 gene in Thailand. Trop Med Health 40(3):79-89 (2012/09). [Abstract]
Kaewthamasorn M, Yahata K, Alexandre JSF, Xangsayarath P, Nakazawa S, Torii M, Sattabongkot J, Udomsangpetch R, Kaneko O. Stable allele frequency distribution of the polymorphic region of SURFIN4.2 in Plasmodium falciparum isolates from Thailand. Parasitol Int 61(2):317-23 (2012/06) [Abstract]
Tsumori Y, Ndounga M, Sunahara T, Hayashida N, Inoue M, Nakazawa S, Casimiro P, Isozumi R, Uemura H, Tanabe K, Kaneko O, Culleton R. Plasmodium falciparum: Differential selection of drug resistance alleles in contiguous urban and peri-urban areas of Brazzaville, Republic of Congo. PLoS ONE 6(8), e23430 (2011/08). [Abstract].
Marchand RP, Culleton R, Maeno Y, Quang NT, Nakazawa S. Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among Humans and Anopheles dirus Mosquitoes, Southern Vietnam. Emerg Infect Dis 17(7), 1232-9 (2011/07). [Abstract]
Alexandre JSF, Kaewthamasorn M, Yahata K, Nakazawa S, Kaneko O. Positive selection on the Plasmodium falciparum clag2 gene encoding a component of the erythrocyte-binding rhoptry protein complex. Trop Med Health 39(3):77-82 (2011). [Abstract]
Nakazawa S, Culleton R, Maeno Y. In vivo and In vitro gametocyte production of Plasmodium falciparum isolates from Northern Thailand.Int J Parasitol 41(3-4), 317-23 (2011/03). [Abstract]
Isozumi R, Uemura H, Le DD, Truong VH, Nguyen DG, Ha VV, Bui QP, Nguyen VT, Nakazawa S. Longitudinal survey of Plasmodium falciparum infection in Vietnam: characteristics of antimalarial resistance and their associated factors. J Clin Microbiol 48(1):70-7 (2010/01) [Abstract]
Nakazawa S, Marchand RP, Nguyen QT, Culleton R, Nguyen MD, Maeno Y. Anopheles dirus co-infection with human and monkey malaria parasites in Vietnam. Int J Parasitol 39(14):1533-7. (2009/12) [Abstract]
Maeno Y, Nakazawa S, Dao LD, Yamamoto N, Giang ND, Van Hanh T, Thuan LK, Taniguchi K. A dried blood sample on filter paper is suitable for detecting Plasmodium falciparum gametocytes by reverse transcription polymerase chain reaction. Acta Trop 107(2):121-7 (2008) [Abstract]
Maeno Y,
Nakazawa S, Dao le D, Van Tuan N, Giang ND, Van Hanh T,
Taniguchi K. Osteopontin is involved in Th1-mediated immunity
against Plasmodium falciparum infection in a holoendemic
malaria region in Vietnam. Acta Trop.
2006 Jul;98(3):305-10.
[Abstract]
Maeno Y,
Nakazawa S, Yamamoto N, Shinzato M, Nagashima S, Tanaka K,
Sasaki J, Rittling SR, Denhardt DT, Uede T, Taniguchi K.
Osteopontin participates in Th1-mediated host resistance against
nonlethal malaria parasite Plasmodium chabaudi chabaudi
infection in mice. Infect Immun.
2006 Apr;74(4):2423-7.
[Abstract]
Nakazawa S.
Plasmodium berghei NK65: studies on the effect of treatment
duration and inoculum size on recrudescence.
Exp Parasitol. 2005 Sep;111(1):59-63.
[Abstract]
Huaman MC, Roncal
N, Nakazawa S, Long TT, Gerena L, Garcia C, Solari L, Magill
AJ, Kanbara H. Polymorphism of the Plasmodium falciparum
multidrug resistance and chloroquine resistance transporter genes
and in vitro susceptibility to aminoquinolines in isolates from the
Peruvian Amazon. Am J Trop Med Hyg.
2004 May;70(5):461-6.
[Abstract]
Owhashi M, Taoka
Y, Ishii K, Nakazawa S, Uemura H, Kambara H.
Identification of a ubiquitin family protein as a novel neutrophil
chemotactic factor. Biochem Biophys Res
Commun. 2003 Sep 26;309(3):533-9.
[Abstract]
Maeno Y,
Nakazawa S, Nagashima S, Sasaki J, Higo KM, Taniguchi K.
Utility of the dried blood on filter paper as a source of cytokine
mRNA for the analysis of immunoreactions in Plasmodium yoelii
infection. Acta Trop. 2003 Jul;87(2):295-300.
[Abstract]
Long TT,
Nakazawa S, Onizuka S, Huaman MC, Kanbara H. Influence of
CD4+CD25+ T cells on Plasmodium berghei NK65 infection in
BALB/c mice. Int J Parasitol.
2003 Feb;33(2):175-83.
[Abstract]
Long TT, Nakazawa
S, Huaman MC, Kanbara H. Influence of antimalarial
treatment on acquisition of immunity in Plasmodium berghei
NK65 malaria. Clin Diagn Lab Immunol.
2002 Jul;9(4):933-4.
[Abstract]
Nakazawa
S, Maoka T, Uemura H, Ito Y, Kanbara H. Malaria parasites
giving rise to recrudescence in vitro.
Antimicrob Agents Chemother. 2002 Apr;46(4):958-65.
[Abstract]
Kusuhara Y, Maeno
Y, Nagase K, Sakai K, Nakazawa S, Kanbara H, Taniguchi K,
Nakabayashi T. Isolation of antigen from the circulating
immune complex in mice infected with Plasmodium berghei.
Int J Parasitol. 2000 Apr 24;30(5):609-15.
[Abstract]
Maeno Y,
Nakazawa S, Kusuhara Y, Kusakabe M, Nagase K, Kanbara H, Aikawa
M, Nakabayashi T. Tenascin takes part in the progress of
pathological severity in cerebral falciparum infection.
Tokai J Exp Clin Med. 1998 Dec;23(6):267-9.
[Abstract]
Midorikawa Y,
Haque QM, Nakazawa S. Inhibition of malaria-infected
erythrocytes by deoxyspergualin: effect on in vitro growth of
malarial cultures. Chemotherapy.
1998 Nov-Dec;44(6):409-13.
[Abstract]
Smith CD, Brown
AE, Nakazawa S, Fujioka H, Aikawa M. Multi-organ
erythrocyte sequestration and ligand expression in rhesus monkeys
infected with Plasmodium coatneyi malaria.
Am J Trop Med Hyg. 1996 Oct;55(4):379-83.
[Abstract]
Nakazawa S,
Kanbara H, Aikawa M. Plasmodium falciparum:
recrudescence of parasites in culture. Exp
Parasitol. 1995 Dec;81(4):556-63.
[Abstract]
Nakazawa S,
Looareesuwan S, Fujioka H, Pongponratn E, Luc KD, Rabbege J, Aikawa
M. A correlation between sequestered parasitized erythrocytes
in subcutaneous tissue and cerebral malaria.
Am J Trop Med Hyg. 1995 Nov;53(5):544-6.
[Abstract]
Nakazawa S,
Brown AE, Maeno Y, Smith CD, Aikawa M. Malaria-induced
increase of splenic gamma delta T cells in humans, monkeys, and
mice. Exp Parasitol. 1994 Nov;79(3):391-8.
[Abstract]
Maeno Y, Fujioka
H, Hollingdale MR, Ockenhouse CF, Nakazawa S, Aikawa M.
Ultrastructural localization of CD36 in human hepatic sinusoidal
lining cells, hepatocytes, human hepatoma (HepG2-A16) cells, and C32
amelanotic melanoma cells. Exp Parasitol.
1994 Nov;79(3):383-90.
[Abstract]
Fujioka H, Millet
P, Maeno Y, Nakazawa S, Ito Y, Howard RJ, Collins WE, Aikawa
M. A nonhuman primate model for human cerebral malaria: rhesus
monkeys experimentally infected with Plasmodium fragile.
Exp Parasitol. 1994 Jun;78(4):371-6.
[Abstract]
Tegoshi T,
Udomsangpetch R, Brown A, Nakazawa S, Webster HK, Aikawa M.
Ultrastructure of rosette formation by Plasmodium coatneyi-infected
erythrocytes of rhesus. Parasitol Res.
1993;79(7):611-3.
[No Abstract]
Jongwutiwes S,
Tanabe K, Nakazawa S, Uemura H, Kanbara H. Coexistence
of GP195 alleles of Plasmodium falciparum in a small endemic
area. Am J Trop Med Hyg. 1991
Mar;44(3):299-305.
[Abstract]
Jongwutiwes S,
Tanabe K, Nakazawa S, Yanagi T, Kanbara H. Sequence
variation in the tripeptide repeats and T cell epitopes in P190
(MSA-1) of Plasmodium falciparum from field isolates.
Mol Biochem Parasitol. 1992 Mar;51(1):81-9.
[Abstract]
Waki S,
Nakazawa S, Taverne J, Targett GA, Playfair JH. Immunity
to an attenuated variant of Plasmodium berghei: role of some
non-specific factors. Parasitology.
1985 Oct;91(Pt 2):263-72.
[Abstract]
Waki S, Miyagami
T, Nakazawa S, Igarashi I, Suzuki M. Maintenance and
propagation of human malaria parasites in culture using an ordinary
CO2 incubator. Trans R Soc Trop Med Hyg.
1984;78(3):418.
[No Abstract]
総説
Suzuki M, Waki S,
Igarashi I, Takagi T, Miyagami T, Nakazawa S. An alternative
approach to malaria vaccine with a permanent attenuated mutant from
a high virulence Plasmodium berghei strain.
Zentralbl Bakteriol Mikrobiol Hyg [A].
1987 May;264(3-4):319-25.
[Abstract] |
賞
日本熱帯医学会 相川正道賞, 2012.
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