2023

1.

Effect of geranylated dihydrochalcone from Artocarpus altilis leaves extract on Plasmodium falciparum ultrastructural changes and mitochondrial malate: Quinone oxidoreductase. Hidayati AR, Melinda, Ilmi H, Sakura T, Sakaguchi M, Ohmori J, Hartuti ED, Tumewu L, Inaoka DK, Tanjung M, Yoshida E, Tokumasu F, Kita K, Mori M, Dobashi K, Nozaki T, Syafruddin D, Hafid AF, Waluyo D, Widyawaruyanti A. Int J Parasitol Drugs Drug Resist. 2023, Apr ;21:40-50. doi: 10.1016/j.ijpddr.2022.12.001.

2.

Killing Two Birds with One Stone: Discovery of Dual Inhibitors of Oxygen and Fumarate Respiration in Zoonotic Parasite, Echinococcus multilocularis.Enkai S, Kouguchic H, Inaoka DK, Shiba T, Hidaka M, Matsuyama H, Sakura T, Yagi K, Kita K. AAC (ASM). 2023, Mar 16;67(3):e0142822. doi: 10.1128/aac.01428-22.

3.

Biochemical characterization and identification of ferulenol and embelin as potent inhibitors of malate:quinone oxidoreductase from Campylobacter jejuni. Kabongo AT, Acharjee R, Sakura T, Bundutidi GM, Hartuti ED, Davies C,Gundogdu O, Kita K, Shiba T, Inaoka DK. Front Mol Biosci. 2023, Jan 26;10:1095026. doi: 10.3389/fmolb.2023.1095023.

2022

4.

Data on the combined effect of atovaquone, mefloquine, and 3-bromopyruvic acid against Echinococcus multilocularis protoscoleces. Kouguchi H, Enkai S, Matsuyama H, Hidaka M, Inaoka DK, Kita K, Yagi K. Data Brief. 2022, Oct 28;45:108707. doi: 10.1016/j.dib.2022.108707.

5.

Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes. Alshaweesh J, Nakamura R, Tanaka Y, Hayashishita M, Musa A, Kikuchi M, Inaoka DK, Hamano S. Microbiology Spectrum (ASM). 2022, Oct 26;10(5):e0112622.

6.

Siccanin Is a Dual-Target Inhibitor of Plasmodium falciparum Mitochondrial Complex II and Complex III. Komatsuya K, Sakura T, Shiomi K, Ōmura S, Hikosaka K, Nozaki T, Kita K and Inaoka DK. Pharmaceuticals. 2022, 15(7), 903.

7.

「寄生虫ミトコンドリアの多様な代謝系：抗寄生虫薬開発からミトコンドリア病の解析まで」
Diversity of mitochondrial metabolism from parasites: From drug development to tool for analysis of mitochondria diseases. Inaoka DK, Hayashishita M, Kita K and Sakura T. Seikagaku 2022, 94(2): 218-229. doi:10.14952/SEIKAGAKU.2022.940218.

8.

5-Aminolevulinic acid antiviral efficacy against SARS-CoV-2 omicron variant in vitro. Ngwe Tun MM, Sakura T, Sakurai Y, Kurosaki Y, Inaoka DK, Shioda N, Smith C, Yasuda J, Morita K, Kita K. Trop Med Health. 2022, 27;50(1):30. doi:10.1186/s41182-022-00422-7.

9.

Antiviral activity of 5-aminolevulinic acid against variants of severe acute respiratory syndrome coronavirus 2. Ngwe Tun MM, Sakura T, Sakurai Y, Kurosaki Y, Inaoka DK, Shinoda N, Yasuda J, Kita K, Morita K. Trop Med Health. 2022, 50:6. doi:10.1186/s41182-021-00397-x

2021

10.

Exploring natural microbial resources for the discovery of anti-malarial compounds. Waluyo D, Prabandari EE, Pramisandi A, Hidayati DN, Chrisnayanti E, Puspitasari DJ, Dewi D, Suryani, Kristiningrum, Oktaviani AN, Afrianti KR, Nonaka K, Matsumoto A, Tokiwa T, Adipratiwi N, Ariyani T, Hartuti ED, Putri TZ, Rahmawati Y, Inaoka DK, Miyazaki Y, Sakura T, Nurlaila, Siska E, Kurnia K, Bernawati P, Melinda, Mahsunah AH, Nugroho NB, Mori M, Dobashi K, Yamashita M, Nurkanto A, Watanabe A, Shiomi K, Wibowo AE, Nozaki T. Parasitol Int. 2021 Dec 85:102432. doi: 10.1016/j.parint.2021.102432.

11.

Rhoptry kinase protein 39 (ROP39) is a novel factor that recruits host mitochondria to the parasitophorous vacuole of Toxoplasma gondii. Fukumoto J, Sakura T, Matsubara R, Tahara M, Matsuzaki M, Nagamune K. Biol Open. 2021 Sep 15;10(9):bio058988. doi: 10.1242/bio.058988.

12.

Biochemical Studies of Mitochondrial Malate: Quinone Oxidoreductase from Toxoplasma gondii. Acharjee R, Talaam KK, Hartuti ED, Matsuo Y, Sakura T, Gloria BM, Hidano S, Kido Y, Mori M, Shiomi K, Sekijima M, Nozaki T, Umeda K, Nishikawa Y, Hamano S, Kita K, Inaoka DK. Int J Mol Sci. 2021 Jul 22;22(15):7830. doi: 10.3390/ijms22157830.

13.

Mitochondria as a Potential Target for the Development of Prophylactic and Therapeutic Drugs against Schistosoma mansoni Infection. Talaam KK, Inaoka DK, Hatta T, Tsubokawa D, Tsuji N, Wada M, Saimoto H, Kita K, Hamano S. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0041821. doi: 10.1128/AAC.00418-21.

14.

Identification of 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase. Hartuti ED, Sakura T, Tagod MSO, Yoshida E, Wang X, Mochizuki K, Acharjee R, Matsuo Y, Tokumasu F, Mori M, Waluyo D, Shiomi K, Nozaki T, Hamano S, Shiba T, Kita K, Inaoka DK. Int J Mol Sci. 2021 Jul 5;22(13):7236. doi: 10.3390/ijms22137236.

15.

The Trypanosome UDP-Glucose Pyrophosphorylase Is Imported by Piggybacking into Glycosomes, Where Unconventional Sugar Nucleotide Synthesis Takes Place. Villafraz O, Baudouin H, Mazet M, Kulyk H, Dupuy JW, Pineda E, Botté C, Inaoka DK, Portais JC, Bringaud F. mBio. 2021 Jun 29;12(3):e0037521. doi: 10.1128/mBio.00375-21.

16.

Gentisyl alcohol and homogentisic acid: Plasmodium falciparum dihydroorotate dehydrogenase inhibitors isolated from fungi. Pramisandi A, Kurnia K, Chrisnayanti E, Bernawati P, Dobashi K, Mori M, Mahsunah AH, Nonaka K, Matsumoto A, Kristiningrum, Hidayati DN, Dewi D, Prabandari EE, Amalia E, Rahmawati Y, Nurkanto A, Inaoka DK, Waluyo D, Kita K, Nozaki T, Ōmura S, Shiomi K. J Gen Appl Microbiol. 2021 Jul 31;67(3):114-117. doi: 10.2323/jgam.2020.08.004.

17.

In vivo efficacy of combination therapy with albendazole and atovaquone against primary hydatid cysts in mice. Enkai S, Kouguchi H, Inaoka DK, Irie T, Yagi K, Kita K. Eur J Clin Microbiol Infect Dis. 2021 Sep;40(9):1815-1820. doi: 10.1007/s10096-021-04230-5.

18.

Interaction between transforming Theileria parasites and their host bovine leukocytes. Tajeri S, Haidar M, Sakura T, Langsley G. Mol Microbiol. 2021 May;115(5):860-869. doi: 10.1111/mmi.14642.

19.

Characterization of Plasmodium falciparum Pantothenate Kinase and Identification of Its Inhibitors From Natural Products. Nurkanto A, Jeelani G, Santos HJ, Rahmawati Y, Mori M, Nakamura Y, Goto K, Saikawa Y, Annoura T, Tozawa Y, Sakura T, Inaoka DK, Shiomi K, Nozaki T. Front Cell Infect Microbiol. 2021 Mar 9;11:639065. doi: 10.3389/fcimb.2021.639065. eCollection 2021

20.

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro. Sakurai Y, Ngwe Tun MM, Kurosaki Y, Sakura T, Inaoka DK, Fujine K, Kita K, Morita K, Yasuda J. Biochem Biophys Res Commun. 2021 Mar 19;545:203-207. doi: 10.1016/j.bbrc.2021.01.091.

21.

The ubiquinone synthesis pathway is a promising drug target for Chagas disease. Nara T, Nakagawa Y, Tsuganezawa K, Yuki H, Sekimata K, Koyama H, Ogawa N, Honma T, Shirouzu M, Fukami T, Matsuo Y, Inaoka DK, Kita K, Tanaka A. PLoS One. 2021 Feb 4;16(2):e0243855. doi: 10.1371/journal.pone.0243855. eCollection 2021.

22.

Weak O2 binding and strong H2O2 binding at the non-heme diiron center of trypanosome alternative oxidase. Yamasaki S, Shoji M, Kayanuma M, Sladek V, Inaoka DK, Matsuo Y, Shiba T, Young L, Moore AL, Kita K, Shigeta Y.Biochim Biophys Acta Bioenerg. 2021 Apr 1;1862(4):148356. doi: 10.1016/j.bbabio.2020.148356.

2020

23.

Effect of the anti-parasitic compounds pyrvinium pamoate and artemisinin in enzymatic and culture assays: Data on the search for new anti-echinococcal drugs. Enkai S, Kouguchi H, Inaoka DK, Irie T, Yagi K, Kita K. Data Brief. 2020 Dec 9;34:106629. doi: 10.1016/j.dib.2020.106629. eCollection 2021 Feb.

24.

Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target. Sato D, Hartuti ED, Inaoka DK, Sakura T, Amalia E, Nagahama M, Yoshioka Y, Tsuji N, Nozaki T, Kita K, Harada S, Matsubayashi M, Shiba T. Genes (Basel). 2020 Dec 7;11(12):1468. doi: 10.3390/genes11121468.

25.

Plasmodium falciparum multidrug resistance gene-1 polymorphisms in Northern Nigeria: implications for the continued use of artemether-lumefantrine in the region. Adamu A, Jada MS, Haruna HMS, Yakubu BO, Ibrahim MA, Balogun EO, Sakura T, Inaoka DK, Kita K, Hirayama K, Culleton R, Shuaibu MN. Malar J. 2020 Nov 30;19(1):439. doi: 10.1186/s12936-020-03506-z.

26.

The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei. Mochizuki K, Inaoka DK, Mazet M, Shiba T, Fukuda K, Kurasawa H, Millerioux Y, Boshart M, Balogun EO, Harada S, Hirayama K, Bringaud F, Kita K. Biochim Biophys Acta Bioenerg. 2020 Nov 1;1861(11):148283. doi: 10.1016/j.bbabio.2020.148283.

27.

Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979. Pramisandi A, Dobashi K, Mori M, Nonaka K, Matsumoto A, Tokiwa T, Higo M, Kristiningrum, Amalia E, Nurkanto A, Inaoka DK, Waluyo D, Kita K, Nozaki T, Ōmura S, Shiomi K. J Gen Appl Microbiol. 2020 Nov 30;66(5):273-278. doi: 10.2323/jgam.2019.11.007.

28.

Kinetic and structural characterisation of the ubiquinol-binding site and oxygen reduction by the trypanosomal alternative oxidase. Young L, Rosell-Hidalgo A, Inaoka DK, Xu F, Albury M, May B, Kita K, Moore AL. Biochim Biophys Acta Bioenerg. 2020 Oct 1;1861(10):148247. doi: 10.1016/j.bbabio.2020.148247.

29.

Mitochondrial complex III in larval stage of Echinococcus multilocularis as a potential chemotherapeutic target and in vivo efficacy of atovaquone against primary hydatid cysts. Enkai S, Inaoka DK, Kouguchi H, Irie T, Yagi K, Kita K. Parasitol Int. 2020 Apr ;75:102004. doi: 10.1016/j.parint.2019.102004.

2019

30.

Theileria parasites subvert E2F signaling to stimulate leukocyte proliferation. Tretina K, Haidar M, Madsen-Bouterse SA, Sakura T, Mfarrej S, Fry L, Chaussepied M, Pain A, Knowles DP, Nene VM, Ginsberg D, Daubenberger CA, Bishop RP, Langsley G, Silva JC. Sci Rep. 2020 Mar 4;10(1):3982. doi: 10.1038/s41598-020-60939-x.

31.

Molecular and biological analysis revealed genetic diversity and high virulence strain of Toxoplasma gondii in Japan. Fukumoto J, Yamano A, Matsuzaki M, Kyan H, Masatani T, Matsuo T, Matsui T, Murakami M, Takashima Y, Matsubara R, Tahara M, Sakura T, Takeuchi F, Nagamune K. PLoS One. 2020 Feb 3;15(2):e0227749. doi: 10.1371/journal.pone.0227749.

32.

Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I. Uno S, Masuya T, Shinzawa-Itoh K, Lasham J, Haapanen O, Shiba T, Inaoka DK, Sharma V, Murai M, Miyoshi H. J Biol Chem. 2020 Feb 21;295(8):2449-2463. doi: 10.1074/jbc.RA119.012347.

33.

Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei. Balogun EO, Inaoka DK, Shiba T, Tsuge C, May B, Sato T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PAM, Watanabe YI, Moore AL, Harada S, Kita K. FASEB J. 2019 Nov;33(11):13002-13013. doi: 10.1096/fj.201901342R.

34.

Identification of Plasmodium falciparum Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box. Wang X, Miyazaki Y, Inaoka DK, Hartuti ED, Watanabe YI, Shiba T, Harada S, Saimoto H, Burrows JN, Benito FJG, Nozaki T, Kita K. Genes (Basel). 2019 Jun 21;10(6):471. doi: 10.3390/genes10060471.

35.

Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum. Araki Y, Awakawa T, Matsuzaki M, Cho R, Matsuda Y, Hoshino S, Shinohara Y, Yamamoto M, Kido Y, Inaoka DK, Nagamune K, Ito K, Abe I, Kita K. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8269-8274. doi: 10.1073/pnas.1819254116.

36.

Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase. Shiba T, Inaoka DK, Takahashi G, Tsuge C, Kido Y, Young L, Ueda S, Balogun EO, Nara T, Honma T, Tanaka A, Inoue M, Saimoto H, Harada S, Moore AL, Kita K. Biochim Biophys Acta Bioenerg. 2019 May 1;1860(5):375-382. doi: 10.1016/j.bbabio.2019.03.008.

2018

37.

Novel Characteristics of Mitochondrial Electron Transport Chain from Eimeria tenella. Matsubayashi M, Inaoka DK, Komatsuya K, Hatta T, Kawahara F, Sakamoto K, Hikosaka K, Yamagishi J, Sasai K, Shiba T, Harada S, Tsuji N, Kita K. Genes (Basel). 2019 Jan 8;10(1):29. doi: 10.3390/genes10010029.

38.

Pathological and molecular diagnosis of canine babesiosis in Nigeria: A case report. Abalaka SE, Ubah SA, Umeakuana PU, Idoko IS, Sani NA, Obeta SS, Hikosaka K, Inaoka DK, Kita K, Watanabe YI, Balogun EO. Vet Parasitol Reg Stud Reports. 2018 Dec;14:150-154. doi: 10.1016/j.vprsr.2018.10.004.

39.

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions. Miyazaki Y, Inaoka DK, Shiba T, Saimoto H, Sakura T, Amalia E, Kido Y, Sakai C, Nakamura M, Moore AL, Harada S, Kita K. Front Pharmacol. 2018 Sep 4;9:997. doi: 10.3389/fphar.2018.00997. eCollection 2018.

40.

Fates of Evolutionarily Distinct, Plastid-type Glyceraldehyde 3-phosphate Dehydrogenase Genes in Kareniacean Dinoflagellates. Kamikawa R, Yazaki E, Tahara M, Sakura T, Matsuo E, Nagamune K, Hashimoto T, Inagaki Y. J Eukaryot Microbiol. 2018 Jul;65(5):669-678. doi: 10.1111/jeu.12512.

41.

Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense. Ebiloma GU, Ayuga TD, Balogun EO, Gil LA, Donachie A, Kaiser M, Herraiz T, Inaoka DK, Shiba T, Harada S, Kita K, de Koning HP, Dardonville C. Eur J Med Chem. 2018 Apr 25;150:385-402. doi: 10.1016/j.ejmech.2018.02.075.

42.

Dihydroorotate Dehydrogenase as a Target for the Development of Novel Helicobacter pylori-Specific Antimicrobials. Ohishi T, Inaoka DK, Kita K, Kawada M. Chem Pharm Bull (Tokyo). 2018;66(3):239-242. doi: 10.1248/cpb.c17-00796.

43.

Monotherapy with a novel intervenolin derivative, AS-1934, is an effective treatment for Helicobacter pylori infection. Ohishi T, Masuda T, Abe H, Hayashi C, Adachi H, Ohba SI, Igarashi M, Watanabe T, Mimuro H, Amalia E, Inaoka DK, Mochizuki K, Kita K, Shibasaki M, Kawada M. Helicobacter. 2018 Apr;23(2):e12470. doi: 10.1111/hel.12470.

2017

44.

Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors. Yamashita T, Inaoka DK, Shiba T, Oohashi T, Iwata S, Yagi T, Kosaka H, Miyoshi H, Harada S, Kita K, Hirano K. Sci Rep. 2018 Feb 5;8(1):2427. doi: 10.1038/s41598-018-20775-6.

45.

Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L-malate:quinone oxidoreductase, a potential drug target. Hartuti ED, Inaoka DK, Komatsuya K, Miyazaki Y, Miller RJ, Xinying W, Sadikin M, Prabandari EE, Waluyo D, Kuroda M, Amalia E, Matsuo Y, Nugroho NB, Saimoto H, Pramisandi A, Watanabe YI, Mori M, Shiomi K, Balogun EO, Shiba T, Harada S, Nozaki T, Kita K. Biochim Biophys Acta Bioenerg. 2018 Mar;1859(3):191-200. doi: 10.1016/j.bbabio.2017.12.004.

46.

Glycerol kinase of African trypanosomes possesses an intrinsic phosphatase activity. Balogun EO, Inaoka DK, Shiba T, Tokuoka SM, Tokumasu F, Sakamoto K, Kido Y, Michels PAM, Watanabe YI, Harada S, Kita K. Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2830-2842. doi: 10.1016/j.bbagen.2017.07.028.

47.

In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease. Yoshino R, Yasuo N, Hagiwara Y, Ishida T, Inaoka DK, Amano Y, Tateishi Y, Ohno K, Namatame I, Niimi T, Orita M, Kita K, Akiyama Y, Sekijima M. Sci Rep. 2017 Jul 27;7(1):6666. doi: 10.1038/s41598-017-06411-9.

48.

Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei brucei. Wang X, Inaoka DK, Shiba T, Balogun EO, Allmann S, Watanabe YI, Boshart M, Kita K, Harada S. Protein Expr Purif. 2017 Oct;138:56-62. doi: 10.1016/j.pep.2017.06.011.

49.

Suppression of experimental cerebral malaria by disruption of malate:quinone oxidoreductase. Niikura M, Komatsuya K, Inoue SI, Matsuda R, Asahi H, Inaoka DK, Kita K, Kobayashi F. Malar J. 2017 Jun 12;16(1):247. doi: 10.1186/s12936-017-1898-5.

2002 - 2016

Please visit the following links.
Inaoka Ken Daniel
Research map: https://researchmap.jp/10623803/published_papers
Researchgate: https://www.researchgate.net/profile/Daniel-Inaoka/research

Takaya Sakura
Research map: https://researchmap.jp/-2qE3_xt/published_papers
Researchgate: https://www.researchgate.net/profile/Takaya-Sakura/research