長崎大学 熱帯医学研究所 病原体解析部門 原虫学分野 上村

 

  上村 春樹, PhD
  講師
大阪大学理学部化学科卒業, 1976. [Link]
大阪大学大学院薬学研究科薬品化学修了, 1982. [Link]
米国 エール大学 ポスドク, 1982-1985.
米国 ニューヨーク大学 研究員, 1989-1991.
長崎大学熱帯医学研究所原虫学分野 助手を経て講師, 1987-現在.
住所   郵便番号852‐8523
長崎市坂本1丁目12‐4
電話/FAX (095)-819-7838 / (095)-819-7805
電子メール  
学術的興味 トリパノソーマ原虫感染におけるトランスシアリダーゼの役割
手技手法   生化学・分子生物学
研究テーマ :: 業績

   
研究テーマ

1.トリパノソーマ原虫の原虫表面トランスシアリダーゼの構造と機能
2.トランスシアリダーゼ反応阻害剤の開発
 
業績

主要な原著論文

Mita T, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja CW, Win ZZ, Htike WW, Marma AS, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale WS, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira MU, Bjorkman A, Endo H, Ohashi J. Little Polymorphism at the K13 Propeller Locus in Worldwide Plasmodium falciparum Populations Prior to the Introduction of Artemisinin Combination Therapies. Antimicrob Agents Chemother 60(6):3340-7. (2016/05) [Abstract]

Isozumi R, Uemura H, Kimata I, Ichinose Y, Logedi J, Omar AH, Kaneko A. Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum. Emerg Infect Dis 21(3):490-2 (2015/03) [Abstract]

Basuki S, Fitriah, Riyanto S, Budiono, Dachlan YP, Uemura H. Two novel mutations of pfdhps K540T and I588F, affecting sulphadoxine-pyrimethamine-resistant response in uncomplicated falciparum malaria at Banjar district, South Kalimantan Province, Indonesia. Malar J 13:135 (2014/04) [Abstract]

Isozumi R, Uemura H, Le DD, Truong VH, Nguyen DG, Ha VV, Bui QP, Nguyen VT, Nakazawa S. Longitudinal survey of Plasmodium falciparum infection in Vietnam: characteristics of antimalarial resistance and their associated factors. J Clin Microbiol 48(1):70-7 (2010/01) [Abstract]

Rubin-de-Celis SS, Uemura H, Yoshida N, Schenkman S.  Expression of trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole.  Cell Microbiol. 2006 Dec;8(12):1888-98. [Abstract]

Alcantara-Neves NM, Ribeiro-dos-Santos R, Amor AL, Uemura H, Silva-Neto SJ, Eichinger D, Pontes-de-Carvalho L.  Parasite-derived trans-sialidase binds to heart tissue in Trypanosoma cruzi-infected animals. Microb Pathog. 2004 Nov;37(5):273-8. [Abstract]

Nagamune K, Acosta-Serrano A, Uemura H, Brun R, Kunz-Renggli C, Maeda Y, Ferguson MA, Kinoshita T.  Surface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors.  J Exp Med. 2004 May 17;199(10):1445-50. [Abstract]

Ramirez MI, Yamauchi LM, de Freitas LH Jr, Uemura H, Schenkman S.  The use of the green fluorescent protein to monitor and improve transfection in Trypanosoma cruzi. Mol Biochem Parasitol. 2000 Nov;111(1):235-40. [No Abstract]

Saavedra E, Herrera M, Gao W, Uemura H, Pereira MA.  The Trypanosoma cruzi trans-sialidase, through its COOH-terminal tandem repeat, upregulates interleukin 6 secretion in normal human intestinal microvascular endothelial cells and peripheral blood mononuclear cells. J Exp Med. 1999 Dec 20;190(12):1825-36. [Abstract]

Smith LE, Uemura H, Eichinger D.  Isolation and expression of an open reading frame encoding sialidase from Trypanosoma rangeli. Mol Biochem Parasitol. 1996 Jul;79(1):21-33. [Abstract]

Egima CM, Briones MR, Freitas Junior LH, Schenkman RP, Uemura H, Schenkman S.  Organization of trans-sialidase genes in Trypanosoma cruzi. Mol Biochem Parasitol. 1996 May;77(2):115-25. [Abstract]

Uemura H, Schenkman S, Nussenzweig V, Eichinger D.  Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities. EMBO J. 1992 Nov;11(11):3837-44. [Abstract]
 

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