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研究テーマ
１．トリパノソーマ原虫の原虫表面トランスシアリダーゼの構造と機能
２．トランスシアリダーゼ反応阻害剤の開発
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業績
主要な原著論文
 Basuki S, Fitriah, Risamasu PM, Kasmijati, Ariami P, Riyanto S, Hidayat A, Susilowati D, Iskandar, Armika B, Budiono, Dachlan YP, Kanbara H, Uemura H. Origins and spread of novel genetic variants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates in Indonesia. Malar J 17(1):475 (2018/12) [PubMed]
Mita T, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja CW, Win ZZ, Htike WW, Marma AS, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale WS, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira MU, Bjorkman A, Endo H, Ohashi J. Little Polymorphism at the K13 Propeller Locus in Worldwide Plasmodium falciparum Populations Prior to the Introduction of Artemisinin Combination Therapies. Antimicrob Agents Chemother 60(6):3340-7. (2016/05) [Abstract]
Isozumi R, Uemura H, Kimata I, Ichinose Y, Logedi J, Omar AH, Kaneko A. Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum. Emerg Infect Dis 21(3):490-2 (2015/03) [Abstract]
Basuki S, Fitriah, Riyanto S, Budiono, Dachlan YP, Uemura H. Two novel mutations of pfdhps K540T and I588F, affecting sulphadoxine-pyrimethamine-resistant response in uncomplicated falciparum malaria at Banjar district, South Kalimantan Province, Indonesia. Malar J 13:135 (2014/04) [Abstract]
Isozumi R, Uemura H, Le DD, Truong VH, Nguyen DG, Ha VV, Bui QP, Nguyen VT, Nakazawa S. Longitudinal survey of Plasmodium falciparum infection in Vietnam: characteristics of antimalarial resistance and their associated factors. J Clin Microbiol 48(1):70-7 (2010/01) [Abstract]
Rubin-de-Celis
SS, Uemura H, Yoshida N, Schenkman S. Expression of
trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole.
Cell Microbiol. 2006 Dec;8(12):1888-98.
[Abstract]
Alcantara-Neves
NM, Ribeiro-dos-Santos R, Amor AL, Uemura H, Silva-Neto SJ,
Eichinger D, Pontes-de-Carvalho L. Parasite-derived trans-sialidase
binds to heart tissue in Trypanosoma cruzi-infected animals.
Microb Pathog. 2004 Nov;37(5):273-8.
[Abstract]
Nagamune K,
Acosta-Serrano A, Uemura H, Brun R, Kunz-Renggli C, Maeda Y,
Ferguson MA, Kinoshita T. Surface sialic acids taken from the
host allow trypanosome survival in tsetse fly vectors.
J Exp Med. 2004 May 17;199(10):1445-50.
[Abstract]
Ramirez MI,
Yamauchi LM, de Freitas LH Jr, Uemura H, Schenkman S.
The use of the green fluorescent protein to monitor and improve
transfection in Trypanosoma cruzi. Mol
Biochem Parasitol. 2000 Nov;111(1):235-40.
[No Abstract]
Saavedra E,
Herrera M, Gao W, Uemura H, Pereira MA. The Trypanosoma cruzi trans-sialidase, through its COOH-terminal tandem repeat,
upregulates interleukin 6 secretion in normal human intestinal
microvascular endothelial cells and peripheral blood mononuclear
cells. J Exp Med. 1999 Dec 20;190(12):1825-36.
[Abstract]
Smith LE,
Uemura H, Eichinger D. Isolation and expression of an open
reading frame encoding sialidase from Trypanosoma rangeli.
Mol Biochem Parasitol. 1996 Jul;79(1):21-33.
[Abstract]
Egima CM, Briones
MR, Freitas Junior LH, Schenkman RP, Uemura H, Schenkman S.
Organization of trans-sialidase genes in Trypanosoma cruzi.
Mol Biochem Parasitol. 1996 May;77(2):115-25.
[Abstract]
Uemura H,
Schenkman S, Nussenzweig V, Eichinger D. Only some members of
a gene family in Trypanosoma cruzi encode proteins that express both
trans-sialidase and neuraminidase activities.
EMBO J. 1992 Nov;11(11):3837-44.
[Abstract]
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