長崎大学熱帯医学研究所臨床感染症学分野・長崎大学病院感染症内科（熱研内科）

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教授：有吉紅也
有吉　紅也 （ありよし　こうや）
Koya ARIYOSHI
長崎大学熱帯医学研究所　臨床感染症学分野　教授
長崎大学病院感染症内科（熱研内科）教授
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略　歴
出身高校（卒業年） 京都府立鴨沂高校（1978年）
出身大学（卒業年） 旭川医科大学医学部（1986年）
専門領域 臨床疫学、熱帯医学、感染症学
研究テーマ 発展途上国におけるHIV/AIDS、ベトナムとフィリピンにおける感染症臨床研究
所属学会 日本公衆衛生学会
日本エイズ学会
日本ウイルス学会
日本熱帯医学会（平成18年1月1日〜評議員、平成21年1月1日〜平成23年12月31日理事 監事）
日本感染症学会(評議委員)
日本呼吸器学会
日本内科学会（平成21年4月1日〜評議員）
英国王立熱帯医学・衛生学会
日本結核病学会
Internal Medicine編集委員
Tropical Medicine and Health編集委員
学　歴
1979年4月～1986年3月 旭川医科大学　医学部
1989年3月～1989年5月 ロンドン大学衛生熱帯医学校
熱帯医学・衛生に関するディプローマコース
1989年6月～1989年8月 ジンバブエ大学　医学部
卒後内科研修
1989年9月～1990年9月 ロンドン大学衛生熱帯医学校
臨床熱帯医学修士課程
1992年～1998年10月 英国オープン大学博士課程（指導教官：英国医学研究協議会ガンビア研究所副所長Hilton Whittle教授、ロンドン大学Richard Teddar 教授、ロンドン大学Robin Weiss教授およびオックスフォード大学分子医学研究所Andrew McMichael教授）
職　歴（業務歴）
1986年～88年 河北総合病院研修医
1989年 英国王立内科学会熱帯医学・衛生学ディプロマ
1989年 ジンバブエ大学医学部修練医
1989年～90年 ロンドン大学衛生熱帯医学大学院　臨床熱帯　医学修士
1990年～92年 英国インペリアル・カレッジ医学校　臨床研究員
1992年 オックスフォード大学分子医学研究所客員研究員
1992年～98年 英国医学研究協議会(MRC)ガンビア研究所
上級研究員MRC病院・ガンビア共和国医師会登録医
1998年～2005年 国立感染症研究所エイズ研究センター　主任研究員・JICAタイ国立衛生研究所機能強化プロジェクト長期専門家
2005年～現在 長崎大学熱帯医学研究所臨床感染症学分野　教授・長崎大学病院感染症内科（熱研内科）教授
研究歴
1989年 ジンバブエの保健医療分析
1990年～1992年 HIV-1ウイルス量分析
Saquinavir 臨床治験
急性期中和抗体の分析
1992年 A33拘束性HIV特異的細胞障害性Tリンパ細胞エピトープ解析
1992年～1998年 HIV-2ウイルス量分析
HIV-2細胞障害性Tリンパ細胞HIV-1とHIV-2の母子感染
HIV-2とカポジ肉腫
HIV-1/-2重複感染
1998年～2005年 マラリア/HIV重複感染
HTLV-I/HIV-2重複感染
HIV臨床株のCTLエピトープ提示
西アフリカHIV分子疫学
非サブタイプBのHIV-1薬剤耐性
北タイにおけるHIVコホート研究
2005年以降 北タイにおけるHIVコホート研究（2010年終了）
中部ベトナムにおける大規模地域住民コホート研究（小児肺炎、デング熱、下痢症など）
フィリピンサンラザロ病院における感染症臨床研究（レプトスピラ症、結核など）
資格（認定医、専門医など）
1986年3月 医学士　旭川医科大学
1986年5月 医師免許取得
1989年6月 ＤＴＭＨ(Diploma in Tropical Medicine and Hygiene)
英国王立内科学会熱帯医学衛生専門医
1990年9月 修士(with distinction)及びFredric Margatroid賞受賞
ロンドン大学
1992年11月 ガンビア医学協議会登録医
1998年10月 博士号　英国オープン大学
博士論文タイトル： “The Role of Viral Load In The Pathogenesis of HIV-2 Infection In West Africa”
主な業績
  • Mori M, Wichukchinda N, Miyahara R, Rojanawiwat A, Pathipvanich P, Maekawa T, Miura T, Goulder P, Yasunami M, Ariyoshi K, Sawanpanyalert P. HLA-B*35:05 is a protective allele with a unique structure amongst HIV-1 CRF01_AE-infected Thais, where the B*57 frequency is low.AIDS. 2014 in press.
  • Takaki M, Nakama T, Ishida M, Morimoto H, Nagasaki Y, Shiramizu R, Hamashige N, Chikamori M, Yoshida L, Ariyoshi K, Suzuki M, Morimoto K. High Incidence of Community-Acquired Pneumonia among Rapidly Ageing Population in Japan：A Prospective Hospital-Based Surveillance. Japanese Journal of Infectious Diseases.2014 in press.
  • Yamashita Y, Hoshino Y, Oka M, Matsumoto S, Ariga H, Nagai H, Makino M, Ariyoshi K, Yokota-Tsunetsugu Y. Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens. Jpn. J. Infect. Dis., 66, 207-215, 2013.
  • Dhoubhadel BG, Yasunami M, Yoshida LM, Nguyen Thi HA, Vu Thi TH, Nguyen Thi TA, Watanabe K, Suzuki M, Morimoto K, Dang DA, Ariyoshi K. A novel high-throughput method for molecular serotyping and serotype-specific quantification of Streptococcus pneumoniae using a nanofluidic real time PCR system. J Med Microbiol. 2014 Jan 25.
  • Suzuki M, Dhoubhadel BG, Yoshida LM, Ariyoshi K. Nasopharyngeal bacterial interactions in children. Emerg Infect Dis. 2014 Feb;20(2):323-4.
  • Shimazaki T, Marte SD, Saludar NR, Dimaano EM, Salva EP, Ariyoshi K, Villarama JB, Suzuki M. Risk factors for death among hospitalised tuberculosis patients in poor urban areas in Manila, The Philippines. Int J Tuberc Lung Dis. 2013 Nov;17(11):1420-6.
  • Harada Y, Kinoshita F, Yoshida LM, Minh le N, Suzuki M, Morimoto K, Toku Y, Tomimasu K, Moriuchi H, Ariyoshi K. Does respiratory virus coinfection increases the clinical severity of acute respiratory infection among children infected with respiratory syncytial virus? Pediatr Infect Dis J. 2013 May;32(5):441-5.
  • Takahashi K, Suzuki M, Minh le N, Anh NH, Huong LT, Son TV, Long PT, Ai NT, Tho le H, Morimoto K, Kilgore PE, Anh DD, Ariyoshi K, Yoshida LM. The incidence and aetiology of hospitalised community-acquired pneumonia among Vietnamese adults: a prospective surveillance in Central Vietnam. BMC Infect Dis. 2013 Jul 1;13:296.
  • Yoshida LM, Nguyen HA, Watanabe K, Le MN, Nguyen AT, Vu HT, Yoshino H, Suzuki M, Takahashi K, Le T, Moriuch H, Kilgore PE, Edmond K, Mulholland K, Dang DA, Ariyoshi K. Incidence of radiologically-confirmed pneumonia and Haemophilus influenzae type b carriage before Haemophilus influenzae type b conjugate vaccine introduction in Central Vietnam. J Pediatr. 2013 Jul;163(1 Suppl):S38-43.
  • Yoshida LM, Suzuki M, Nguyen HA, Le MN, Dinh Vu T, Yoshino H, Schmidt 　WP, Nguyen TT, Le HT, Morimoto K, Moriuchi H, Dang DA, Ariyoshi K. Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections. Eur Respir J. 2013 Aug;42(2):461-9.
  • Daito H, Suzuki M, Shiihara J, Kilgore PE, Ohtomo H, Morimoto K, Ishida M, Kamigaki T, Oshitani H, Hashizume M, Endo W, Hagiwara K, Ariyoshi K, Okinaga S. Impact of the Tohoku earthquake and tsunami on pneumonia hospitalisations and mortality among adults in northern Miyagi, Japan: a multicentre observational study. Thorax. 2013 Jun;68(6):544-50.
  • Rojanawiwat, A, Miura T, Thaisri H, Pathipvanich P, Umnajsirisuk S, Koibuchi T, Vongsheree S, Iwamoto A, Ariyoshi K, Sawanpanyalert P. Frequent Detection of Epstein-Barr Virus and Cytomegalovirus but not JC Virus DNA in Cerebrospinal Fluid Samples from Human Immunodeficiency Virus-Infected Patients in Northern Thailand. J Clin Microbiol. 2005 Jul;43(7):3484-6.
  • Kantor R, Katzenstein DA, Efron B, Carvalho AP, Wynhoven B, Cane P, Clarke J, Sirivichayakul S, Soares MA, Snoeck J, Pillay C, Rudich H, Rodrigues R, HolguinA, Ariyoshi K, Bouzas MB, Cahn P, Sugiura W, Soriano V, Brigido LF, Grossman Z,Morris L, Vandamme AM, Tanuri A, Phanuphak P, Weber JN, Pillay D, Harrigan PR,Camacho R, Schapiro JM, Shafer RW. Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration. PLoS Med. 2005 Apr;2(4):e112. Epub 2005 Apr 26.
  • Wichukchinda N, Shiino T, Srisawat J, Rojanawiwat A, Pathipvanich P, Sawanpanyalert P, Ariyoshi K, Auwanit W. Heterosexual transmission of novel CRF01_AE and subtype B recombinant forms of HIV-1 in northern Thailand. AIDS Res Hum Retroviruses. 2005 Aug;21(8):734-8.
  • Hansmann A, Schim van der Loeff MF, Kaye S, Awasana AA, Sarge-Njie R, O’Donovan D, Ariyoshi K, Alabi A, Milligan P, Whittle HC. Baseline plasma viral load and CD4 cell percentage predict survival in HIV-1- and HIV-2- infected women in a community-based cohort in The Gambia. J. Acqur Immune Defic Syndr. 2005 Mr 1; 38(3): 335-41.
  • Pathipvanich P, Rojanawiwat A, Ariyoshi K, Miura T, Pumpradit W, Wongchoosie S, Yingseree P, Warachit P, Sawanpanyalert P., Mortality analysis of HIV-1 infected patients for prioritizing antiretroviral drug therapy. J Med Assoc Thai. 2004; 87: 951-954.
  • Saeng-Aroon S, Wichukchinda N, Myint L, Pathipvanich P, Ariyoshi K, Rojanawiwat A, Matsuda M, Sawanpanyalert P, Sugiura W, Auwanit W. Study of Antiretroviral Drug-Resistant HIV-1 Genotypes in Northern Thailand: Role of Mutagenically Separated Polymerase Chain Reaction as a Tool for monitoring Zodovudine-Resistant HIV-1 in Resource-Limited Settings. J Acquir Immune Defic Syndr. 2004 Aug 15; 36(5): 1051-56.
  • Yokomaku Y, Miura H, Tomiyama H, Kawana-Tachikawa A, Takiguchi M, Kojima A, Nagai Y, Iwamoto A, Matsuda Z, Ariyoshi K. Impaired Processing and Presentation of Cytotoxic-T-Lymphocyte (CTL) Epitopes Are Major Escape Mechanisms from CTL Immune Pressure in Human Immunodeficiency Virus Type 1 Infection. J Virol. 2004 Feb; 78(3): 1324-32.
  • Ariyoshi K, Berry N, Cham F, Jaffar S, Schim van der Loeff M, Jobe O, N'Gom　PT, Larsen O, Andersson S, Aaby P, Whittle H. Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality. J Infect Dis. 2003 Dec 1; 188(11): 1648-51.
  • Schim Van Der Loeff MF, Hansmann A, Awasana AA, Ota MO, O'Donovan D,　Sarge-Njie R, Ariyoshi K, Milligan P, Whittle H. Survival of HIV-1 and HIV-2 perinatally infected children in The Gambia. AIDS. 2003 Nov 7; 17(16): 2389-2394.
  • Ariyoshi K, Matsuda M, Miura H, Tateishi S, Yamada K, Sugiura W. Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. J Acquir Immune Defic Syndr. 2003 Jul 1; 33(3): 336-42.
  • Alabi AS, Jaffar S, Ariyoshi K, Blanchard T, Schim van der Loeff M, Awasana　AA, Corrah T, Sabally S, Sarge-Njie R, Cham-Jallow F, Jaye A, Berry N, Whittle　H. Plasma viral load, CD4 cell percentage, HLA and survival of HIV-1, HIV-2, and dually infected Gambian patients. AIDS. 2003 Jul 4; 17(10): 1513-20.
  • Pathipvanich P, Ariyoshi K, Rojanawiwat A, Wongchoosie S, Yingseree P, Yoshiike K, Warachit P, Sawanpanyalert P. Survival benefit from non-highly active antiretroviral therapy in a resource-constrained setting. J Acquir Immune Defic Syndr. 2003 Feb 1; 32(2): 157-60.
  • Berry N, Jaffar S, Van Der Loeff MS, Ariyoshi K, Harding E, N'Gom PT, Dias F, Wilkins A, Ricard D, Aaby P, Tedder R, Whittle H. Low level viremia and high CD4% predict normal survival in a cohort of HIV type-2-infected villagers. AIDS Res Hum Retroviruses. 2002 Nov 1;18(16):1167-73.
  • Myint L, Ariyoshi K, Yan H, Frater AJ, Auwanit W, Pathipvanith P, Yamada K, Matsuda M, Chiba T, Fujita K, McClure M, Weber JN, Sugiura W. Mutagenically separated PCR assay for rapid detection of M41L and K70R zidovudine resistance mutations in CRF01_AE (subtype E) human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2002 Dec;46(12):3861-8.
  • Schim van der Loeff MF, Jaffar S, Aveika AA, Sabally S, Corrah T, Harding E, Alabi A, Bayang A, Ariyoshi K, Whittle HC. Mortality of HIV-1, HIV-2 and HIV-2/HIV-2 udally infected patients in a clinic-based cohort in The Gambia. AIDS 2002; 16: 1775-83.
  • Ariyoshi K, Promadej N, Ruxrungtham K, Sutthent R. Toward improved evaluation of cytotoxic T-lymphocyte (CTL)-inducing HIV vaccines in Thailand. AIDS Res Hum Retorivurses. 2002; 18: 737-9.
  • Holmgren B, Andersson S, Harding E, van der Loeff MS, Vastrup P, Aaby P, Ariyoshi K, Whittle H. Increased prevalence of HTLV-1 among HIV-2-infected women but not HIV-2-infected men in rural Guinea-Bissau. J Acquir Immune defic Syndro. 2002; 30: 342-50.
  • Frater AJ, Dunn DT, Beardall AJ, Ariyoshi K, Clarke JR, McClure MO, Weber JN. Comparatice response of African HIV-1-infected individuals to highly active antiretroviral therapy. AIDS 2002; 16: 1139-46.
  • Yagyu F, Ikeda Y, Ariyoshi K, Sugiura W, Wongkhomthong SA, Masuda M, Ushijima H. Differentiation of subtypes B and E of human immunodeficiency virus type 1 by polymerase chain reaction using novel env gene primers. J Virol Methods. 2002; 101: 11-20.
  • Frater AJ, Beardall A, Ariyoshi K, Chrchill D, Galpin S, Clarke JR, Weber JN, McClure MO. Impact of baselyne polymorphisms in RT and protease on outcome of highly active antiretroviral therapy in HIV-1-infected African patients. AIDS 2001; 15: 1493-502.
  • Van der Loeff MFS, Aaby P, Ariyoshi K, Vincent T, Awasana AA, Da Costa C, Pembery L, Dias F, Harding E, Weiss HA, Whittle HC. HIV-2 does not protect against HIV-1 infection in a rural comm.unity in Guinea-Bissau. AIDS 2001; 15: 2303-10.
  • Berry N, Ariyoshi K, Balfe P, Tedder R, Whittle H. Sequence specificity of the human immunodeficiency virus type 2 (HIV-2) long terminal repeat U3 region in vivo allows subtyping of the principal HIV-2 viral subtypes A and B. AIDS Res Hum Retro 2001; 17:253-7.
  • Ariyoshi K and Whittle H. HIV-1 viral load and scrub typhus [letter]. Lancet 2000; 356: 1776.
  • Kano M, Matano T, Nakamura H, Takeda A, Kato A, Ariyoshi K, Mori K, Sata T, Nagai Y. Elicitation of protective immunity against simian immunodeficiency virus infection by a recombinant Sendai virus expressing the Gag protein [letter]. AIDS 2000; 14: 1281-1282.
  • O'Donovan D, Ariyoshi K, Milligan P, et al. Maternal plasma viral RNA levels determine marked differences in mother-to-child transmission rates of HIV-1 and HIV-2 in The Gambia. MRC/Gambia Government/University College London Medical School working group on mother-child transmission of HIV. AIDS 2000; 14: 441-448.
  • Ota MO, O'Donovan D, Alabi AS, Milligan P, Yamuah LK, N’Gom PT, Harding E, Ariyoshi K, Hilkins A, Whittle HC. Maternal HIV-1 and HIV-2 infection and child survival in The Gambia. AIDS 2000; 14: 435-439.
  • Ariyoshi K, Jaffar S, Alabi AS, Berry N, Schim van der Loeff M, Sabally S, N'Gom PT, Corrah T, Tedder R, Whittle H. Plasma RNA viral load predicts the rate of CD4 T cell decline and death in HIV-2-infected patients in West Africa. AIDS 2000; 14: 339-344.
  • Hassan-King M, Newport M, Baldeh I, Adegbola R, Corrah T, Lienhardt C, Ariyoshi K, Whittle H, and McAdam KPWJ. Use of PCR to diagnose pulmonary tuberculosis using DNA from peripheral blood mononuclear cells of HIV and non-HIV infected patients. Newport M. Int J Tuberc Lung Dis1999; 3 (suppl. 1), S76-S77.
  • Jaffar S, Ariyoshi K, Frith P, Okouchi Y, Sabally S, Ajewole T, Bailey R, Lee PS, Corrah T, Johnson G, Faal H, Whittle H. Retinal manifestations of HIV-1 and HIV-2 infections among hospital patients in The Gambia, west Africa. Trop Med Int Health 1999; 4: 487-492.
  • Cook PM, Whitby D, Calabro ML, Luppi M, Kakoola DN, Hjalgrim H, Ariyoshi K, Ensoli B, Dacison AJ, Shulz TF. Variability and evolution of Kaposi's sarcoma-associated herpesvirus in Europe and Africa. International Collaborative Group. AIDS 1999; 13: 1165-1176.
  • Ariyoshi K, van der Loeff MS, Berry N, Jaffar S, Whittle H. Plasma HIV viral load in relation to season and to Plasmodium falciparum parasitaemia [letter]. AIDS 1999; 13: 1145-1146.
  • Jobe O, Ariyoshi K, Marchant A, Sabally S, Corrah T, Berry N, Jaffar S, Whittle H. Proviral load and immune function in blood and lymph node during HIV-1 and HIV-2 infection. Clin Exp Immunol 1999; 116: 474-478.
  • Rowland-Jones SL, Dong T, Dorrell L, Ogg G, Hansasuta P, Krausa P, Kimani J, Sabally S, Ariyoshi K, Oyugi J, MacDonald KS, Bwayo J, Whittle H, Plummer FA, McMichael AJ. Immunol Lett 1999; 66: 9-14.
  • Berry N, Ariyoshi K, Jaffar S, Sabally S, Corrah T, Tedder R, Whittle H. Low peripheral blood viral HIV-2 RNA in individuals with high CD4 percentage differentiates HIV-2 from HIV-1 infection. J Hum Virol 1998; 1: 457-468.
  • Ariyoshi K, Schim vdL, Cook P, Whitby D, Corrah T, Jaffar S, Cham F, Sabally S, O'Donovan D, Weiss RA, Schulz TF, Whittle H. Kaposi's sarcoma in the Gambia, West Africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency virus type 1 infection despite a high prevalence of human herpesvirus 8. J Hum Virol 1998; 1: 193-199.
  • Ariyoshi K, Cham F, Berry N, Harding E, Sabally S, N'Gom PT, Ishikawa K, Corrah T, Tedder R, Whittle H. Diagnosis of HIV-1/2 dual infection using dilution analysis of type-specific antibody [letter]. AIDS 1998; 12: 2504-2505.
  • Rowland-Jones SL, Dong T, Fowke KR, Kimani J, Krausa P, Newell H, Blanchard T, Ariyoshi K, Oyugi J, Ngugi E, Bwayo J, MacDonald KS, McMichael AJ, Plummer FA. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J Clin Invest 1998; 102: 1758-1765.
  • Grassly NC, Xiang Z, Ariyoshi K, Aaby P, Jensen H, Schim van der Loeff M, Dias F, Whittle H, Breuer J. Mortality among human immunodeficiency virus type 2-positive villagers in rural Guinea-Bissau is correlated with viral genotype. J Virol 1998; 72: 7895-7899.
  • Ishikawa K, Fransen K, Ariyoshi K, Nkengasong JN, Janssens W, Heyndrickx L, Whittle H, Diallo MO, Ghys PD, Coulibaly IM, Greenberg AE, Piedade J, Canas-Ferreira W, van der Groen G. Improved detection of HIV-2 proviral DNA in dually seroreactive individuals by PCR. AIDS 1998; 12: 1419-1425.
  • Whittle HC, Ariyoshi K, Rowland-Jones S. HIV-2 and T cell recognition. Curr Opin Immunol 1998; 10: 382-387.
  • Rowland-Jones S, Colbert RA, Dong T, McAdam S, Brown M, Ariyoshi K, Sabally S, Whittle H, McMichael A. Distinct recognition of closely-related HIV-1 and HIV-2 cytotoxic T-cell epitopes presented by HLA-B*2703 and B*2705 [letter]. AIDS 1998; 12: 1391-1393.
  • N'Gom PT, Jaffar S, Ricard D, Wilkins A, Ariyoshi K, Morgan G, Da Silva AP, Whittle HC. Immune stimulation by syphilis and malaria in HIV-2-infected and uninfected villagers in West Africa. Br J Biomed Sci 1997; 54 : 251-255.
  • McKnight A, Dittmar MT, Moniz-Periera J, Ariyoshi K, Reeves JD, Hibbitts S, Whitby D, Aarons E, Proudfoot AE, Whittle H, Clapham PR A broad range of chemokine receptors are used by primary isolates of human immunodeficiency virus type 2 as coreceptors with CD4. J Virol 1998; 72: 4065-4071.
  • Rowland-Jones S, Dong T, Krausa P, Sutton J, Newell H, Ariyoshi K, Gotch F, Sabally S, Corrah T, Kimani J, MacDonald K, Plummer F, Ndinya-Achola J, Whittle H, McMichael A.The role of cytotoxic T-cells in HIV infection. Dev Biol Stand 1998; 92: 209-214.
  • Bertoletti A, Cham F, McAdam S, Rostron T, Rowland-Jones S, Sabally S, Corrah T, Ariyoshi K, Whittle H. Cytotoxic T cells from human immunodeficiency virus type 2-infected patients frequently cross-react with different human immunodeficiency virus type 1 clades. J Virol 1998; 72: 2439-2448.
  • Ariyoshi K, Schim vdL, Sabally S, Cham F, Corrah T, Whittle H. Does HIV-2 infection provide cross-protection against HIV-1 infection? [letter]. AIDS 1997; 11: 1053-1054.
  • Xiang Z, Ariyoshi K, Wilkins A, Dias F, Whittle H, Breuer J. HIV type 2 pathogenicity is not related to subtype in rural Guinea Bissau. AIDS Res Hum Retroviruses 1997; 13: 501-505.
  • Aaby P, Ariyoshi K, Buckner M, Jensen H, Berry N, Wilkins A, Richard D, Larsen O, Dias F, Melbye M, Whittle H. Age of wife as a major determinant of male-to-female transmission of HIV-2 infection: a community study from rural West Africa. AIDS 1996; 10: 1585-1590.
  • Ariyoshi K, Cheingsong-Popov R, Wilkins A, Corrah T, Weber J, Whittle H. HIV-1 subtype B in west Africa [letter]. Lancet 1996; 347: 328.
  • Bobkov A, Cheingsong-Popov R, Salminen M, McCutchan F, Louwagie J, Ariyoshi K, Whittle H, Weber J. Complex mosaic structure of the partial envelope sequence from a Gambian HIV type 1 isolate. AIDS Res Hum Retroviruses 1996; 12: 169-171.
  • Ariyoshi K, Berry N, Wilkins A, Ricard D, Aaby P, Nauclér A, Ngom PT, Jobe O, Jaffar S, Dias F, Tedder RS, Whittle H. A community-based study of human immunodeficiency virus type 2 provirus load in rural village in West Africa. J Infect Dis 1996; 173: 245-248.
  • Ariyoshi K, Cham F, Berry N, Jaffar S, Sabally S, Corrah T, Whittle H. HIV-2-specific cytotoxic T-lymphocyte activity is inversely related to proviral load. AIDS 1995; 9: 555-559.
  • Kitchen VS, Skinner C, Ariyoshi K, Lane EA, Duncan IB, Burckhardt J, Burger HU, Bragman K, Pinching AJ, Weber JN. Safety and activity of saquinavir in HIV infection. Lancet 1995; 345: 952-955.
  • S Rowland-Jones, J Sutton, K Ariyoshi, T Dong, F Gotch, S McAdam, D Whitby, S Sabally, A Gallimore, T Corrah, M Takiguchi, T Schultz, A McMichael, H Whittle. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nature Medicine 1995; 1: 59-64.
  • Berry N, Ariyoshi K, Jobe O, Ngum PT, Corrah T, Wilkins A, Whittle H, Tedder R. HIV type 2 proviral load measured by quantitative polymerase chain reaction correlates with CD4+ lymphopenia in HIV type 2-infected individuals. AIDS Res Hum Retroviruses 1994; 10: 1031-1037.
  • Ariyoshi K, Bloor S, Bieniasz PD, Bourrelly M, Foxall R, Weber JN. Development of a rapid quantitative assay for HIV-1 plasma infectious viraemia-culture-PCR (CPID). J Med Virol 1994; 43: 28-32.
  • Bieniasz PD, Ariyoshi K, Bourelly MA, Bloor S, Foxall RB, Harwood EC, Weber JN. Variable relationship between proviral DNA load and infectious virus titre in the peripheral blood mononuclear cells of HIV-1-infected individuals. AIDS 1993; 7: 803-806.
  • Rowland-Jones SL, Nixon DF, Aldhous MC, Gotch F, Ariyoshi K, Hallam N, Kroll JS, Froebel K, McMichael A. HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant. Lancet 1993; 341: 860-861.
  • Katseni VL, Gilroy CB, Ryait BK, Ariyoshi K, Bieniasz PD, Weber JN, Taylor-Robinson D. Mycoplasma fermentans in individuals seropositive and seronegative for HIV-1. Lancet 1993; 341: 271-273.
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