Professor

Michio Nakamura, MD, PhD






E-mail：nakamura@net.nagasaki-u.ac.jp

1970

Graduated Kyushu University School of Medicine

1970

MD degree

1975

Completed Kyushu University Postgraduate School of Medicine

1975

Research Associate; Dept. Biochemistry, Kyushu University School of Medicine

1976

PhD degree

1976

Researcher: Research Institute of Kyushu Cancer Center

1979

Faculty Associate: Health Science Center at Dallas, The University of Texas

1981

Instructor: Dept. Biochemistry, Kyushu University School of Medicine

1985

Chief Medical Doctor: Koga Hospital (Kurume, Fukuoka Pref., Japan)

1987

Associate Professor: The Institute of Medical Science, The University of Tokyo

1991

Professor: Institute of Tropical Medicine, Nagasaki University

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The regulation of the phagocyte NADPH oxidase and its role in innate immunity

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Deamination of DNA in tropical diseasess and its repair

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Chemotaxis

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Immunodeficiencies

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The Japanese Biochemical Society (coucilor)

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Japanese Society for Bacteriology (councilor)

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Japanese Society for Immunology (member)

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Japanese Society for Bio-Defense Research (Director)

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Japanese Society of Tropical Medicine (councilor)

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Japan Society for Respiratory Endoscopy (member)

Kokeshi-Japanese wooden dolls-, African masks, classic cameras, camping

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Gunasekara D, Fujii Y, Rusvai E, Yoshiie, Ohashi Nakamaura M. Human onocytic THP-1 cells upregulate superoxide-generating activity and mRNAs for its components in response to heat-stable and heat-unstable factors of medium conditioned by Ehrlichia chaffeensis-infected cells. Acta Med Nagasaki 49: 39-44, 2004 (acceptedApril 20).

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Takata-Yahiro M, Fujii Y, Nodarse JF, Islam MR, Oda S, Zhang QM, Yonei S, Nakamura M. A novel GT-mismatch binding protein that recognizes strict DNA sequences with high affinity. Tohoku J Exp Med. 2003 Aug;200(4):211-229.

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Islam MR, Fan C, Fujii Y, Hao LJ, Suzuki S, Kumatori A, Yang D, Rusvai E, Suzuki N, Kikuchi H, Nakamura M. PU.1 Is Dominant and HAF-1 Supplementary for Activation of the gp91(phox) Promoter in Human Monocytic PLB-985 Cells. J Biochem (Tokyo). 2002 Apr;131(4):533-40.

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Kumatori A, Yang D, Suzuki S, Nakamura M. Cooperation of STAT-1 and IRF-1 in interferon-gamma-induced transcription ofthe gp91(phox) gene. J Biol Chem. 2002 Mar 15;277(11):9103-11.

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Yamauchi A, Yu L, Potgens AJ, Kuribayashi F, Nunoi H, Kanegasaki S, Roos D, Malech HL, Dinauer MC, Nakamura M. Location of the epitope for 7D5, a monoclonal antibody raised against human flavocytochrome b558, to the extracellular peptide portion of primate gp91phox. Microbiol Immunol. 2001;45(3):249-57.

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Burritt JB, DeLeo FR, McDonald CL, Prigge JR, Dinauer MC, Nakamura M, Nauseef WM, Jesaitis AJ. Phage display epitope mapping of human neutrophil flavocytochrome b558. Identification of two juxtaposed extracellular domains. J Biol Chem. 2001 Jan 19;276(3):2053-61.

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Hao LJ, Yang D, Fujii Y, Yamauchi A, Suzuki N, Kikuchi H, Kaneda Y, Nakamura M. Phorbol ester-potentiated liposomal transfection to monocytic PLB-985 cells. J Biochem (Tokyo). 2000 Dec;128(6):989-98.

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Ward RA, Nakamura M, McLeish KR. Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules. J Biol Chem. 2000 Nov 24;275(47):36713-9.

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Yang D, Suzuki S, Hao LJ, Fujii Y, Yamauchi A, Yamamoto M, Nakamura M, Kumatori A. Eosinophil-specific regulation of gp91(phox) gene expression by transcription factors GATA-1 and GATA-2. J Biol Chem. 2000 Mar 31;275(13):9425-32.

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Kumatori A, Faizunnessa NN, Suzuki S, Moriuchi T, Kurozumi H, Nakamura M. Nonhomologous recombination between the cytochrome b558 heavy chain gene (CYBB) and LINE-1 causes an X-linked chronic granulomatous disease. Genomics. 1998 Oct 15;53(2):123-8.

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Sadat MA, Kumatori A, Suzuki S, Yamaguchi Y, Tsuji Y, Nakamura M. GATA-3 represses gp91phox gene expression in eosinophil-committed HL-60-C15 cells. FEBS Lett. 1998 Oct 9;436(3):390-4

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Suzuki S, Kumatori A, Haagen IA, Fujii Y, Sadat MA, Jun HL, Tsuji Y, Roos D, Nakamura M. PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6085-90.

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Faizunnessa NN, Tsuchiya T, Kumatori A, Kurozumi H, Imajoh-Ohmi S,Kanegasaki S, Nakamura M. ?@A 25-kb deletion in the 5' region of the cytochrome b558 heavy chain gene (CYBB) in a patient with X-linked chronic granulomatous disease.Hum Genet. 1997 Apr;99(4):469-73.

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Sumimoto H, Hata K, Mizuki K, Ito T, Kage Y, Sakaki Y, Fukumaki Y, Nakamura M, Takeshige K. Assembly and activation of the phagocyte NADPH oxidase. Specific interaction of the N-terminal Src homology 3 domain of p47phox with p22phox is required for activation of the NADPH oxidase. J Biol Chem. 1996 Sep 6;271(36):22152-8.

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Imajoh-Ohmi S, Tokita K, Ochiai H, Nakamura M, Kanegasaki S. Topology of cytochrome b558 in neutrophil membrane analyzed by anti-peptide antibodies and proteolysis. J Biol Chem. 1992 Jan 5;267(1):180-4.

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Nakamura M, Imajoh-Ohmi S, Kanegasaki S, Kurozumi H, Sato K, Kato S,Miyazaki Y. ?@Prenatal diagnosis of cytochrome-deficient chronic granulomatous disease. Lancet. 1990 Jul 14;336(8707):118-9.

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Kobayashi S, Imajoh-Ohmi S, Nakamura M, Kanegasaki S. Occurrence of cytochrome b558 in B-cell lineage of human lymphocytes. Blood. 1990 Jan 15;75(2):458-61.

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Maly FE, Nakamura M, Gauchat JF, Urwyler A, Walker C, Dahinden CA, Cross AR, Jones OT, de Weck AL. Superoxide-dependent nitroblue tetrazolium reduction and expression of cytochrome b-245 components by human tonsillar B lymphocytes and B cell lines. J Immunol. 1989 Feb 15;142(4):1260-7.

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Nakamura M, Murakami M, Koga T, Tanaka Y, Minakami S. Monoclonal antibody 7D5 raised to cytochrome b558 of human neutrophils: immunocytochemical detection of the antigen in peripheral phagocytes of normal subjects, patients with chronic granulomatous disease, and their carrier mothers. Blood. 1987 May;69(5):1404-8.

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Nakamura M, Baxter CR, Masters BS. Simultaneous demonstration of phagocytosis-connected oxygen consumption and corresponding NAD(P)H oxidase activity: direct evidence for NADPH as the predominant electron donor to oxygen in phagocytizing human neutrophils. Biochem Biophys Res Commun. 1981 Feb 12;98(3):743-51. No abstract available.

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Nakamura M, Nakamura MA, Okamura J, Kobayashi Y. A rapid and quantitative assay of phagocytosis-connected oxygen consumption by leukocytes in whole blood. J Lab Clin Med. 1978 Apr;91(4):568-75.