Immunogenetics

This department primarily focuses on the fundamental insights of the pathogenic genetic factors of the host and the pathogens of tropical infectious diseases such as Dengue fever, malaria and Chagas disease, through the application of immunology and genetics. With the understanding of the dynamic host-pathogen interactions, we are further concerned with the development of new tools to fight against these diseases including novel therapeutics (drugs) or vaccines.

Members

Professor
Kenji Hirayama

Activities

We strive to build a highly interactive and collaborative network for sustainable research activities, and hence, we have various well-arranged collaborative projects with the following overseas and domestic facilities. 1) Research Institute for Tropical Medicine (RITM), Philippines. 2 ) UAGRM, Bolivia, 3) IICS University of Asuncion, Paraguay, 4) Pasteur Institute in HoChiMinh City, and National Institute of Hygiene and Epidemiology (NIHE), Vietnam, 5 ) Ahmadu Bello University, Nigeria, 6) Pasteur Paris, France, 7) London School of Hygiene and Tropical Medicine, UK, 8) National Institutes of Health (NIH), USA, 9) Tokyo Medical and Dental University, 10) Toyama University, 11) The National Institute of Advanced Industrial Science and Technology (AIST) 12) IS Global, Spain
Following research projects are going on.

Malaria
  1. NGS analysis of host and Malaria genome (SATREPS)
Chagas disease
  1. Early bio-markers identification for chronic Chagas disease, namely, indeterminate, cardiac, and digestive forms in Bolivia (KAKENHI)
  2. Anti-trypanosomal drug development (Toyama, Nagasaki)
Dengue
  1. Mechanism of cellular immunity on protection against Dengue virus (KAKENHI)

Recent main research achievement

  1. Hung et al. Int J Infect Dis 2022;120:217-227.
  2. Mohammed et al. PLoS Negl Trop Dis 2022;16(3):e0010309
  3. Mizoguchi et al. ALTEX 2022;doi:10.14573/altex.2111181.
  4. Thach et al. PLoS Negl Trop Dis 2022;16(1):e0010164.
  5. Ngwe Tun et al. J Nat Med 2022;76(2):402-409.

Achievement list