Clinical Medicine

This is the only clinical department in NEKKEN, which does clinical practices in Nagasaki University Hospital. We conduct a wide range of multi-disciplinary studies bridging our strength of clinical epidemiology to laboratory-based microbiology and immunology both in-and outside Japan. Our main research interests are respiratory infectious diseases, acute undifferentiated febrile illness, tuberculosis (TB) and HIV/AIDS. Specific research topics are as described below:

Members

Professor
Koya Ariyoshi
Professor (Respiratory)
Konosuke Morimoto
Professor (TMGH)
Chris Smith
Associate Professor
Yoshinao Kubo
Assistant Professor
Mai Izumida
Assistant Professor
Momoko Yamauchi
Visiting Professor
Michio Yasunami
Visiting Professor
Takao Ohmagari
Visiting Professor
Motoi Suzuki
Visiting Professor
Eiichiro Sando
Visiting Professor
Bailey Robin
Visiting Professor
Sakib N Burza
Visiting Researcher
Nobuo Saito
Visiting Researcher
Emi Kitashoji
Visiting Researcher
Kentaro Sakashita
Assistant Researcher
Taisuke Nakamura
Assistant
Rina Shiramizu
Assistant
Kyoko Uchibori
Assistant
Megumi Michitsuji
Assistant
Naomi Kitada
Assistant
Yumi Araki
Assistant
Fumiyo Tsujita
Graduate Student
Hiroshi Fujii
Graduate Student
Eriko Ikeda
Graduate Student
Tohru Ogasawara
Graduate Student
Kentaro Hayashi
Graduate Student
Haruka Maeda
Graduate Student
Koki Shimizu
Graduate Student
Olivier Tshiani Mbaya
Graduate Student
Carol Susan Devamani
Graduate Student
Saho Takaya
Graduate Student
Yuka Nakamura
Graduate Student
Su Myat Han
Graduate Student
Mukadi Kakoni Patrick

Activities

Respiratory Infections Diseases, including Tuberculosis

We apply our in-house multiplex-PCR assays to id entify 19 different viral and bacterial respiratory pathogens and a novel nano-fluidic real-time PCR-based assay to determine 50 pneumococcus serotypes for studies in-and outside Japan. We also conduct TB research with a special interest in TB-specific cellular immune responses protective to the disease progression. In response to SARS-CoV-2 pandemic, we started to conduct clinical epidemiology research on COVID-19 in the Philippines in early 2020.

Fever management in the tropical countries

It’s challenging to diagnose and manage non-malarial fever without localizing sign such as leptospirosis, rickettsiosis, dengue fever, which are common in the tropical countries. We are investigating acute undifferentiated febrile illness in the Department of Infectious Diseases, Bac Mai Hospital, Hanoi, Vietnam and the National Infectious Disease Hospital (San Lazaro Hospital), the Philippines, by applying various new diagnostic tests.

HIV/AIDS Studies and others

In collaboration with National Institute of Health, Thailand, we have conducted a natural history cohort of HIV infection. New research is still on-going based on the data and clinical samples derived from the cohort. Furthermore, we investigate molecular mechanisms of pathogenesis caused by retroviruses and other microbials.

Recent main research achievement

  1. Saito et al. Clin Infect Dis 2021;72:61-68.
  2. Mukadi et al. PLoS Negl Trop Dis 2021;15:e0009670.
  3. Domai et al. Lancet Reg Health West Pac 2021;19:100334.
  4. Yanagisawa et al. PLoS One 2020;15:e0242438.
  5. Katoh et al. PLoS Negl Trop Dis 2019;13:e0007928.

Achievement list