Department of Protozoology
 Nagasaki Univ   Institute of Tropical Medicine Department of Protozoology Kaneko2

Osamu Kaneko, MD, PhD


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Research Article
[Invasion of the erythrocytes]

Kaneko O, Tsuboi T, Ling IT, Howell S, Shirano M, Tachibana M, Cao YM, Holder AA, Torii M. The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii. Mol Biochem Parasitol 118(2):223-31 (2001). [Abstract]

Mayer DCG, Kaneko O, Hudson-Taylor D, Reid ME, Miller LH. Characterization of a Plasmodium falciparum erythrocyte binding protein paralogous to EBA-175. Proc Natl Acad Sci U. S. A98(9): 5222-7 (2001) [Abstract] [Full Text]

Shirano M, Tsuboi T, Kaneko O, Tachibana M, Adams JH, Torii M. Conserved Regions of the Plasmodium yoelii Rhoptry Protein RhopH3 Revealed by Comparison with the P. falciparum Homologue. Mol Biochem Parasitol 112: 279-9 (2001) [No Abstract]

Kaneko O, Fidock DA, Schwartz OM, Miller LH. Disruption of the C-terminal region of EBA-175 in the Dd2/Nm clone of Plasmodium falciparum does not affect erythrocyte invasion. Mol Biochem Parasitol 110(1): 135-146 (2000) [Abstract]

Kaneko O, Soubes SC, Miller LH, Plasmodium falciparum: Invasion of Aotus monkey red blood cells and adaptation to Aotus monkeys. Exp Parasitol 93: 116-119 (1999) [No Abstract]

Soubes SC, Reid ME, Kaneko O, Miller LH. Search for the Sialic Acid-Independent Receptor on Red Blood Cells for Invasion by Plasmodium falciparum. Vox Sang 76(2): 107-114 (1999) [Abstract]

[Molecular Epidemiology of malaria parasites]

Kimura M, Kaneko O, Inoue A, Ishii A, Tanabe K. Amplification by polymerase chain reaction of Plasmodium falciparum DNA from Giemsa-stained thin blood smears. Mol Biochem Parasitol 70: 193-197 (1995) [No Abstract]

Kaneko O, Jongwutiwes S, Kimura M, Kanbara H, Ishii A, Tanabe K. Plasmodium falciparum: variation in block 4 of the precursor to the major merozoite surface proteins in natural populations. Exp Parasitol 84: 92-95 (1996) [No Abstract]

Kaneko O, Kimura M, Kawamoto F, Ferreira MU, Tanabe K. Plasmodium falciparum: Allelic variation in the merozoite surface protein 1 gene in wild isolates from Southern Vietnam. Exp Parasitol 86: 45-57 (1997) [Abstract]

Ferreira MU, Liu Q, Zhou M, Kimura M, Kaneko O, Thien HV, Isomura S, Tanabe K, Kawamoto F. Stable patterns of allelic diversity at the Merozoite surface protein-1 locus of Plasmodium falciparum in Clinical isolates from southern Vietnam. J Eukaryot Microbiol 45(1): 131-136 (1998) [Abstract]

Ferreira MU, Liu Q, Kaneko O, Kimura M, Tanabe K, Kimura EAS, Kazin AM, Isomura S, Kawamoto F. Allelic diversity at the merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from the southwestern Brazilian Amazon. Am J Trop Med Hyg 59(3): 474-480 (1998) [Abstract]

Tanabe K, Sakihama N, Nakamura Y, Kaneko O, Kimura M, Ferreira MU, Hirayama K. Selection and genetic drift of polymorphisms within the merozoite surface protein-1 gene of Plasmodium falciparum. Gene 241(2): 325-331 (2000) [Abstract]

Alexandre JSF, Kaewthamasorn, Yahata K, Nakazawa S, Kaneko O. Positive selection on the Plasmodium falciparum clag2 gene encoding a component of the erythrocyte-binding rhoptry protein complex. Trop Med Health 39(3):77-82 (2011). [Abstract]

Sungkapong T, Culleton R, Yahata K, Tachibana M, Ruengveerayuth R, Udomsangpetch R, Torii M, Tsuboi T, Sattabongkot J, Kaneko O, Chotivanich K. Humoral immune responses to Plasmodium vivax subtelomeric transmembrane proteins in Thailand. Southeast Asian J Trop Med Public Health 42(6):1313-21 (2011/11) [Abstract]

Tang J, Dai Y, Zhang H, Culleton Rl, Liu Y, Zhao S, Wang X, Guan X, Kaneko O, Zhu Y. Positive diversifying selection on Plasmodium vivax RON2 protein. Parasitology 139(6):709-15 (2012/05) [Abstract]

Kaewthamasorn M, Yahata K, Alexandre JSF, Xangsayarath P, Nakazawa S, Torii M, Sattabongkot J, Udomsangpetch R, Kaneko O. Stable allele frequency distribution of the polymorphic region of SURFIN4.2 in Plasmodium falciparum isolates from Thailand. Parasitol Int 61(2):317-23 (2012/06) [Abstract]

Alexandre JSF, Xangsayarath P, Kaewthamasorn, Yahata K, Sattabongkot J, Udomsangpetch R, Kaneko O. Stable allele frequency distribution of the Plasmodium falciparum clag genes encoding components of the high molecular weight rhoptry protein complex. Trop Med Health 40(3):71-7 (2012/09) [Abstract]

Xangsayarath P, Kaewthamasorn K, Yahata K, Nakazawa S, Sattabongkot J, Udomsangpetch R, Kaneko O. Positive diversifying selection on the Plasmodium falciparum surf4.1 gene in Thailand. Trop Med Health 40(3):79-89 (2012/09) [Abstract]

Miao M, Wang Z, Yang Z, Yuan L, Parker DM, Putaporntip C, Jongwutiwes S, Xangsayarath P, Pongvongsa T, Moji H, Dinh Tuong T, Abe T, Nakazawa S, Kyaw MP, Yan G, Sirichaisinthop J, Sattabongkot J, Mu J, Su XZ, Kaneko O, Cui L. Genetic Diversity and Lack of Artemisinin Selection Signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion. PLoS ONE 8(3):e59192.(2013) [Abstract]

[Others articles related to Plasmodium]

Zhu X, He Y, Liang Y, Kaneko O, Cui L, Cao Y. Tryptophan-rich domains of Plasmodium falciparum SURFIN4.2 and Plasmodium vivax PvSTP2 interact with membrane skeleton of red blood cell. Malar J 16(1):121 (2017/03) [Abstract].

Ebine K, Hirai M, Sakaguchi M, Yahata K, Kaneko O, Saito-Nakano Y. Plasmodium Rab5b is secreted to the cytoplasmic face of the tubovesicular network in infected red blood cells together with N-acylated adenylate kinase 2. Malar J 15(1):323 (2016/06) [Abstract]

Sakaguchi M, Miyazaki N, Fujioka H, Kaneko O, Murata K. Three-dimensional analysis of morphological changes in the malaria parasite infected red blood cell by serial block-face scanning electron microscopy. J Struct Biol 193(3):162-71 (2016/03) [Abstract]

Tachibana M, Suwanabun N, Kaneko O, Iriko H, Otsuki H, Sattabongkot J, Kaneko A, Herrera S, Torii M, Tsuboi T. Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization. Vaccine 33(16):1901-8 (2015/04) [Abstract]

Kawamoto F, Miyake H, Kaneko O, Kimura M, Nguyen TD, Nguyen TD, Liu Q, Zhou M, Le DD, Kawai S, Isomura S, Wataya Y, Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam. J Clin Microbiol 34: 2287-2289 (1996) [Abstract] [Reprint]

Kimura M, Kaneko O, Liu Q, Zhou M, Kawamoto F, Wataya S, Otani S, Yamaguchi Y, Tanabe K. Identification of the four species of human malaria parasites by nested PCR that targets various sequences in the small subunit rRNA gene. Parasitology International 46(2): 91-95 (1997) [Abstract]

Kaneko A, Kaneko O, Taleo G, Bjorkman A, Kobayakawa T. High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu. The Lancet 349: 921-922 (1997) [No Abstract]

Kaneko A, Bergqvist Y, Takechi M, Kalkoa M, Kaneko O, Kobayakawa T, Ishizaki T, Bjorkman A. Intrinsic Efficacy of Proguanil Against Falciparum and Vivax Malaria Independent of the Metabolite Cycloguanil. J Infect Dis 179(4): 974-979 (1999) [Abstract] [Reprint]

Nagao E, Kaneko O, Dvorak JA, Plasmodium falciparum-Infected Erythrocytes: Qualitative and Quantitative Analyses of Parasite-Induced Knobs by Atomic Force Microscopy. J Struct Biol 130(1): 34-44 (2000) [Abstract]


Tachibana M, Tsuboi T, Templeton TJ, Kaneko O, Torii M. Presence of three distinct ookinete surface protein genes, Pos25, Pos28-1, and Pos28-2 in Plasmodium ovale. Mol Biochem Parasitol 113:341-4 (2001) [No Abstract]

Tachibana M, Tsuboi T, Kaneko O, Khuntirat B, Torii M. Two types of Plasmodium ovale defined by SSU rRNA have distinct sequences for ookinete surface proteins. Mol Biochem Parasitol 122:223-6 (2002) [No Abstract]

Tsuboi T, Kaneko O, Eitoku C, Suwanabun N, Sattabongkot J, Vinetz JM, Torii M. Gene structure and ookinete expression of the chitinase genes of Plasmodium vivax and Plasmodium yoelii Mol Biochem Parasitol 130(1):51-4 (2003). [No Abstract]

Tsuboi T, Kaneko O, Cao YM, Tachibana M, Yakushijin Y, Nagao T, Kanbara H, Torii M.  A rapid genotyping method for the vivax malaria transmission-blocking vaccine candidates, Pvs25 and Pvs28.  Parasitol Int 53:211–6 (2004) [Abstract]

Kaneko O, Templeton TJ, Iriko H, Tachibana M, Otsuki H, Takeo S, Sattabongkot J, Torii M, Tsuboi T.  The Plasmodium vivax homolog of the ookinete adhesive micronemal protein, CTRP Parasitol Int 55:227-231 (2006) [Abstract]

Tsuboi T, Takeo S, Iriko H, Jin L, Tsuchimochi M, Matsuda S, Han E-T, Otsuki H, Kaneko O, Sattabongkot J, Udomsangpetch R, Sawasaki T, Torii M, Endo Y. The wheat germ cell-free based production of malaria proteins for discovery of novel vaccine candidates. Infect Immun 76(4):1702-1708 (2008). [Abstract]

Wang Y, Kaneko O, Sattabongkot J, Chen J-H, Lu F, Chai J-Y, Takeo S, Tsuboi T, Ayala FJ, Chen Y, Lim CS, Han ET Genetic Polymorphism of Plasmodium vivax msp1p, a Paralog of Merozoite Surface Protein 1, from Worldwide Isolates. Am J Trop Med Hyg 84(2), 292-297 (2011/02).[Abstract]

Tsumori Y, Ndounga M, Sunahara T, Hayashida N, Inoue M, Nakazawa S, Casimiro P, Isozumi R, Uemura H, Tanabe K, Kaneko O, Culleton R. Plasmodium falciparum: Differential selection of drug resistance alleles in contiguous urban and peri-urban areas of Brazzaville, Republic of Congo. PLoS ONE 6(8), e23430 (2011/08).
[Abstract]

Tachibana M, Sato C, Otsuki H, Sattabongkot J, Kaneko O, Torii M, Tsuboi T. Plasmodium vivax gametocyte protein Pvs230 is a transmission-blocking vaccine candidate. Vaccine 30(10):1807-12 (2012/02).[Abstract]

Inoue M, Jianxia T, Miyakoda M, Kaneko O, Yui K, Culleton R. The species specificity of immunity generated by live whole organism immunization with erythrocytic and pre-erythrocytic stages of rodent malaria parasites and implications for vaccine development Int J Parasitol 42(9):859-70 (2012). [Abstract]

Tachibana S, Sullivan SA, Kawai S, Nakamura S, Kim HR, Goto N, Arisue N, Palacpac NMQ, Honma H, Yagi M, Tougan T, Katakai Y, Kaneko O, Mita T, Kita K, Yasutomi Y, Sutton PL, Shakhbatyan R, Horii T, Yasunaga T, Barnwell JW, Escalante AA, Carlton JM, Tanabe K. Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. Nat Genet 44(9):1051-5 (2012). [Abstract]

Morita M, Sanai H, Hiramoto A, Sato A, Hiraoka O, Sakura T, Kaneko O, Masuyama A, Nojima M, Wataya Y, Kim H-S Plasmodium falciparum endoplasmic reticulum-resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, N-89 and N-251. J Proteome Res 11(12):5704-11 (2012) [Abstract]

Zhao H, Konishi A, Fujita Y, Yagi M, Ohata K, Aoshi T, Itagaki S, Sato S, Narita H, Abdelgelil NH, Inoue M, Culleton R, Kaneko O, Nakagawa A, Horii T, Akira S, Ishii KJ, Coban C. Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism. Cell Host Microbe 12(5), 705-16 (2012/11). [Abstract]

Pattaradilokrat S, Li J, Wu J, Qi Y, Eastman RT, Zilversmit M, Nair SC, Huaman MC, Quinones M, Jiang H, Li N, Zhu J, Zhao K, Kaneko O, Long CA, Su XZ. Plasmodium genetic loci linked to host cytokine and chemokine responses. Genes Immun 15(3):145-52 (2014/04-05) [Abstract]

Abkallo HM, Liu W, Hokama S, Ferreira PE, Nakazawa S, Maeno Y, Quang NT, Kobayashi N, Kaneko O, Huffman MA, Kawai S, Marchand RP, Carter R, Hahn BH, Culleton R. DNA from pre-erythrocytic stage malaria parasites is detectable by PCR in the faeces and blood of hosts. Int J Parasitol 44(7):467-73 (2014/06) [Abstract]

[Others articles unrelated to Plasmodium]

Hakimi H, Yamagishi J, Kegawa Y, Kaneko O, Kawazu SI, Asada M. Establishment of transient and stable transfection systems for Babesia ovata. Parasit Vectors 9:171 (2016/03)

Asada M, Yahata K, Hakimi H, Yokoyama N, Igarashi I, Kaneko O, Suarez CE, Kawazu SI. Transfection of Babesia bovis by double selection with WR99210 and Blasticidin-S and its application for functional analysis of thioredoxin peroxidase-1. PLoS One 10(5):e0125993 (2015/05) [Abstract]

Mossaad E, Asada M, Nakatani D, Inoue N, Yokoyama N, Kaneko O, Kawazu SI. Calcium ions are involved in egress of Babesia bovis merozoites from bovine erythrocytes. J Vet Med Sci. 2014 Oct 7. [Epub ahead of print] [Abstract]

Pandey K, Pandey BD, Mallik AK, Acharya J, Kato K, Kaneko O, Ferreira PE. A new molecular surveillance system for leishmaniasis. Am J Trop Med Hyg  90(6):1082-6 (2014/06) [Abstract]
Pandey BD, Pun SB, Kaneko O, Pandey K, Hirayama K. Expansion of Visceral Leishmaniasis to Western Hilly Part of Nepal. Am J Trop Med Hyg 84(1):107-8 (2011/01). [Abstract]

Pandey K, Pandey BD, Mallik AK, Kaneko O, Uemura H, Kanbara H, Yanagi T, Hirayama K. Diagnosis of visceral leishmaniasis by polymerase chain reaction of DNA extracted from Giemsa’s solution-stained slides. Parasitol Res 2010 Aug;107(3):727-30. [Abstract]

Pandey BD, Pandey K, Kaneko O, Yanagi T, Hirayama K. Relapse of Visceral Leishmaniasis Following Miltefosine Treatment in a Nepalese Patient. Am J Trop Med Hyg 80(4):580-2 (2009/04) [Abstract]

Pandey K, Pant S, Kanbara H, Shuaibu MN, MallikAK, Pandey BD, Kaneko O, Yanagi T.  Molecular detection of Leishmania parasites from whole bodies of sandflies collected in Nepal. Parasitol Res 103(2):293-7 (2008). [Abstract]

Katakura K, Fujise H, Takeda K, Kaneko O, Torii M, Suzuki M, Chang KP, Hashiguchi Y.  Overexpression of LaMDR2, a novel multidrug resistance ATP-binding cassette transporter, causes 5-fluorouracil resistance in Leishmania amazonensisFEBS Let 561(1-3):207-12 (2004). [Abstract]


Review Article

Tsuboi T, Tachibana M, Kaneko O, Torii M. Transmission-blocking vaccine of vivax malaria. Parasitol Int 52(1):1-11 (2003) [Abstract]


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