Department of Protozoology
 Nagasaki Univ   Institute of Tropical Medicine Department of Protozoology Yahata


  Kazuhide Yahata, PhD
  Assistant Professor
Tottori Univ, Faculty of Agriculture, 1999. [Link]
Hiroshima Univ, Graduate School of Science, Master's degree, 2001. [Link]
Osaka Univ, Graduate School of Pharmaceutical Sciences, 2007. [Link]
Address Department of Protozoology
Institute of Tropical Medicine, Nagasaki University
Sakamoto 1-12-4, Nagasaki 852-8523, Japan
Phone / Fax (+81)-95-819-7838 / (+81)-95-819-7805
Scientific Interest Mechanism of the epigenetic silencing of malaria parasite
Technique Cellular and Molecular Biology


Epigenetic gene regulation  of malaria parasites


Research Article

Ishikawa T,Mizuta S, Kaneko O, Yahata K. Fragment molecular orbital study of the interaction between sarco/endoplasmic reticulum Ca2+-ATPase and its inhibitor thapsigargin toward anti-malarial development. J Phys Chem B (in press, DOI: 10.1021/acs.jpcb.8b04509)

Kegawa Y, Asada M, Ishizaki T, Yahata K, Kaneko O. Critical role of Erythrocyte Binding-Like protein of the rodent malaria parasite Plasmodium yoelii to establish an irreversible connection with the erythrocyte during invasion. Parasito Int (in press) [PubMed]

Asare KK, Sakaguchi M, Lucky AB, Asada M, Miyazaki S, Katakai Y, Kawai S, Song C, Murata K, Yahata K, Kaneko O. The Plasmodium knowlesi MAHRP2 ortholog localizes to structures connecting Sinton Mulligan's clefts in the infected erythrocyte. Parasitol Int 67:481-492 (2018/04) [PubMed] [Open Access]

Abkallo HM, Martinelli A, Inoue M, Ramaprasad A, Xangsayarath P, Gitaka J, Tang J, Yahata K, Zoungrana A, Mitaka H, Acharjee A, Datta PP, Hunt P, Carter R, Kaneko O, Mustonen V, Illingworth CJR, Pain A, Culleton R. Rapid identification of genes controlling virulence and immunity in malaria parasites. PLoS Pathog 13(7):e1006447 (2017/07) [Abstract].

Gitaka JN, Takeda M, Kimura M, Idris ZM, Chan CW, Kongere J, Yahata K, Muregi FW, Ichinose Y, Kaneko A, Kaneko O. Selections, frameshift mutations, and copy number variation detected on the surf 4.1 gene in the western Kenyan Plasmodium falciparum population. Malar J 16(1):98 (2017/03) [Abstract]

Lucky AB, Sakaguchi M, Katakai Y, Kawai S, Yahata K, Templeton TJ, Kaneko O. Plasmodium knowlesi Skeleton-Binding Protein 1 Localizes to the 'Sinton and Mulligan' Stipplings in the Cytoplasm of Monkey and Human Erythrocytes. PLoS One 11(10):e0164272. (2016/10) [Abstract]

Ebine K, Hirai M, Sakaguchi M, Yahata K, Kaneko O, Saito-Nakano Y. Plasmodium Rab5b is secreted to the cytoplasmic face of the tubovesicular network in infected red blood cells together with N-acylated adenylate kinase 2. Malar J 15(1):323 (2016/06) [Abstract]

Pandey K, Ferreira PE, Ishikawa T, Nagai T, Kaneko O, Yahata K. Ca2+ monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor. Sci Rep 6:23454 (2016/03)

Mutungi JK, Yahata K, Sakaguchi M, Kaneko O. Isolation of invasive Plasmodium yoelii merozoites with a long half-life to evaluate invasion dynamics and potential invasion inhibitors. Mol Biochem Parasitol 204(1):26-33 (2015/12) [Free Access until Feb/5/2016] [Abstract]

Kagaya W, Miyazaki S, Yahata K, Ohta N, Kaneko O. The cytoplasmic region of Plasmodium falciparum SURFIN4.2 is required for transport from Maurer's clefts to the red blood cell surface. Trop Med Health 43(4):265-272 (2015/12)

Kato K, Yahata K, Gopal Dhoubhadel B, Fujii Y, Tachibana H. Novel hemagglutinating, hemolytic and cytotoxic activities of the intermediate subunit of Entamoeba histolytica lectin. Sci Rep 5:13901 (2015/09). [Abstract]

Asada M, Yahata K, Hakimi H, Yokoyama N, Igarashi I, Kaneko O, Suarez CE, Kawazu SI. Transfection of Babesia bovis by double selection with WR99210 and Blasticidin-S and its application for functional analysis of thioredoxin peroxidase-1. PLoS Onee (in press)

Mutungi JK, Yahata K, Sakaguchi M, Kaneko O. Expression and localisation of rhoptry neck protein 5 in merozoites and sporozoites of Plasmodium yoelii. Parasitol Int 63(6):794-801 (2014/12) [Abstract]

Zhu XT, Yahata K, Alexandre JSF, Tsuboi T, Kaneko O. The N-terminal segment of Plasmodium falciparum SURFIN4.1 is required for its trafficking to the red blood cell cytosol through the endoplasmic reticulum. Parasito Int 62(2):215-29.(2013/04) [Abstract]

Sakura T, Yahata K, Kaneko O. The upstream sequence segment of the C-terminal cysteine-rich domain is required for microneme trafficking of Plasmodium falciparum erythrocyte binding antigen 175. Parasito Int 62(2):157-64.(2013/04) [Abstract]

Yahata K, Treeck M, Culleton R, Gilberger TW, Kaneko O. Time-lapse imaging of red blood cell invasion by the rodent malaria parasite Plasmodium yoelii. PLoS ONE 7(12):e50780 (2012) [Abstract]

Asada M, Goto Y, Yahata K, Yokoyama N, Kawai S, Inoue N, Kaneko O, Kawazu S-I. Gliding motility of Babesia bovis merozoites visualized by time-lapse video microscopy. PLoS ONE 7(4):e35227 (2012). [Abstract]

Kaewthamasorn M, Yahata K, Alexandre JSF, Xangsayarath P, Nakazawa S, Torii M, Sattabongkot J, Udomsangpetch R, Kaneko O. Stable allele frequency distribution of the polymorphic region of SURFIN4.2 in Plasmodium falciparum isolates from Thailand. Parasitol Int 61(2):317-23 (2012/06) [Abstract]

Alexandre JSF, Kaewthamasorn M, Yahata K, Nakazawa S, Kaneko O. Positive selection on the Plasmodium falciparum clag2 gene encoding a component of the erythrocyte-binding rhoptry protein complex. Trop Med Health 39(3):77-82 (2011). [Abstract]

Alexandre JSF, Yahata K, Kawai S, Torii M, Kaneko O. PEXEL-independent trafficking of Plasmodium falciparum SURFIN4.2 to the parasite-infected red blood cell and Maurer's clefts. Parasitol Int 60:313-20 (2011) [Abstract]

Maeshima K, Iino H, Hihara S, Funakoshi T, Watanabe A, Nishimura M, Nakatomi R, Yahata K, Imamoto F, Hashikawa T, Yokota H, Imamoto N. Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase. Nat Struct Mol Biol. 2010 Sep;17(9):1065-71. [Abstract]

Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, Iida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nat Methods. 2008 Dec;5(12):1011-7. [Abstract]

Wendt KS, Yoshida K, Itoh T, Bando M, Koch B, Schirghuber E, Tsutsumi S, Nagae G, Ishihara K, Mishiro T, Yahata K, Imamoto F, Aburatani H, Nakao M, Imamoto N, Maeshima K, Shirahige K, Peters JM. Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature. 2008;451(7180):796-801. [Abstract]

Yahata K, Maeshima K, Sone T, Ando T, Okabe M, Imamoto N, Imamoto F. cHS4 insulator-mediated alleviation of promoter interference during cell-based expression of tandemly associated transgenes. J. Mol. Biol. 2007;374(3):580-90. [Abstract]

Funakoshi T, Maeshima K, Yahata K, Sugano S, Imamoto F, Imamoto N. Two distinct human POM121 genes: Requirement for the formation of nuclear pore complexes. FEBS Lett. 2007;581(25):4910-6. [Abstract]

Maeshima K, Yahata K, Sasaki Y, Nakatomi R, Tachibana T, Hashikawa T, Imamoto F, Imamoto N. Cell cycle-dependent dynamics of nuclear pores: pore-free islands and lamins. J. Cell Science. 2006;119:4442-51 [Abstract]

Sasaki Y, Sone T, Yahata K, Kishine H, Hotta J, Chesnut JD, Honda T, Imamoto F. Multi-gene Gateway clone design for expression of multiple heterologous genes in living cells: Eukaryotic clones containing two and three ORF multi-gene cassettes expressed from a single promoter. J. Biotechnol. 2005; Available online June 24, 2005. [Abstract]

Sone T, Yahata K, Sasaki Y, Hotta J, Kishine H, Chesnut JD, Imamoto F. Multi-gene Gateway clone design for expression of multiple heterologous genes in living cells: Modular construction of multiple cDNA expression elements using recombinant cloning. J. Biotechnol. 2005; Available online June 24, 2005. [Abstract]

Yahata K, Kishine H, Sone T, Sasaki Y, Hotta J, Chesnut JD, Okabe M, Imamoto F. Multi-gene Gateway clone design for expression of multiple heterologous genes in living cells: Conditional gene expression at near physiological levels. J. Biotechnol. 2005;118:123-134. [Abstract]

Sasaki Y, Sone T, Yoshida S, Yahata K, Hotta J, Chesnut JD, Honda T, Imamoto F. Evidence for high specificity and efficiency of multiple recombination signals in mixed DNA cloning by the Multisite Gateway system. J. Biotechnol. 2004;107:233-243. [Abstract]

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