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Theme
1. Role of the surface transsialidase of Trypanosoma
parasites
2. Drug Development for the Trypanosoma transsialidase
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Publications
Selected
Research Articles
 Basuki S, Fitriah, Risamasu PM, Kasmijati, Ariami P, Riyanto S, Hidayat A, Susilowati D, Iskandar, Armika B, Budiono, Dachlan YP, Kanbara H, Uemura H. Origins and spread of novel genetic variants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates in Indonesia. Malar J 17(1):475 (2018/12) [PubMed]
Mita T, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja CW, Win ZZ, Htike WW, Marma AS, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale WS, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira MU, Björkman A, Endo H, Ohashi J. Little Polymorphism at the K13 Propeller Locus in Worldwide Plasmodium falciparum Populations Prior to the Introduction of Artemisinin Combination Therapies. Antimicrob Agents Chemother 60(6):3340-7. (2016/05) [Abstract]
Isozumi R, Uemura H, Kimata I, Ichinose Y, Logedi J, Omar AH, Kaneko A. Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum. Emerg Infect Dis 21(3):490-2 (2015/03) [Abstract]
Basuki S, Fitriah, Riyanto S, Budiono, Dachlan YP, Uemura H. Two novel mutations of pfdhps K540T and I588F, affecting sulphadoxine-pyrimethamine-resistant response in uncomplicated falciparum malaria at Banjar district, South Kalimantan Province, Indonesia. Malar J 13:135 (2014/04) [Abstract]
Isozumi R, Uemura H, Le DD, Truong VH, Nguyen DG, Ha VV, Bui QP, Nguyen VT, Nakazawa S. Longitudinal survey of Plasmodium falciparum infection in Vietnam: characteristics of antimalarial resistance and their associated factors. J Clin Microbiol 48(1):70-7 (2010/01) [Abstract]
Rubin-de-Celis
SS, Uemura H, Yoshida N, Schenkman S. Expression of
trypomastigote trans-sialidase in metacyclic forms of Trypanosoma
cruzi increases parasite escape from its parasitophorous
vacuole.
Cell Microbiol. 2006 Dec;8(12):1888-98.
[Abstract]
Alcantara-Neves NM, Ribeiro-dos-Santos R, Amor AL, Uemura H,
Silva-Neto SJ, Eichinger D, Pontes-de-Carvalho L.
Parasite-derived trans-sialidase binds to heart tissue in
Trypanosoma cruzi-infected animals.
Microb Pathog. 2004 Nov;37(5):273-8.
[Abstract]
Nagamune K,
Acosta-Serrano A, Uemura H, Brun R, Kunz-Renggli C, Maeda Y,
Ferguson MA, Kinoshita T. Surface sialic acids taken from the
host allow trypanosome survival in tsetse fly vectors.
J Exp Med. 2004 May 17;199(10):1445-50.
[Abstract]
Ramirez MI,
Yamauchi LM, de Freitas LH Jr, Uemura H, Schenkman S.
The use of the green fluorescent protein to monitor and improve
transfection in Trypanosoma cruzi.
Mol Biochem Parasitol. 2000 Nov;111(1):235-40.
[No Abstract]
Saavedra E,
Herrera M, Gao W, Uemura H, Pereira MA. The
Trypanosoma cruzi trans-sialidase, through its COOH-terminal
tandem repeat, upregulates interleukin 6 secretion in normal human
intestinal microvascular endothelial cells and peripheral blood
mononuclear cells. J Exp Med.
1999 Dec 20;190(12):1825-36.
[Abstract]
Smith LE,
Uemura H, Eichinger D. Isolation and expression of an open
reading frame encoding sialidase from Trypanosoma rangeli.
Mol Biochem Parasitol. 1996 Jul;79(1):21-33.
[Abstract]
Egima CM,
Briones MR, Freitas Junior LH, Schenkman RP, Uemura H,
Schenkman S. Organization of trans-sialidase genes in
Trypanosoma cruzi.
Mol Biochem Parasitol. 1996 May;77(2):115-25.
[Abstract]
Uemura H,
Schenkman S, Nussenzweig V, Eichinger D. Only some members of
a gene family in Trypanosoma cruzi encode proteins that
express both trans-sialidase and neuraminidase activities.
EMBO J. 1992 Nov;11(11):3837-44.
[Abstract]
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