Department of Protozoology
 Nagasaki Univ   Institute of Tropical Medicine Department of Protozoology Uemura


  Haruki Uemura, PhD
  Senior Assistant Professor
Osaka Univ, Faculty of Science, 1976. [Link]
Osaka Univ, Graduate School of Pharmaceutical Sciences, 1982. [Link]
Yale University, USA, Post-doctral Associate, 1982-1985.
New York University, USA, Research Associate, 1989-1991.
Address Department of Protozoology
Institute of Tropical Medicine, Nagasaki University
Sakamoto 1-12-4, Nagasaki 852-8523, Japan
Phone / Fax (+81)-95-819-7838 / (+81)-95-819-7805
Scientific Interest Role of the Trypanosoma transsialidase in the parasitisms
Technique Biochemistry, Molecular Biology
    Theme :: Publication


1. Role of the surface transsialidase of Trypanosoma parasites
2. Drug Development for the Trypanosoma transsialidase



Selected Research Articles

Mita T, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja CW, Win ZZ, Htike WW, Marma AS, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale WS, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira MU, Björkman A, Endo H, Ohashi J. Little Polymorphism at the K13 Propeller Locus in Worldwide Plasmodium falciparum Populations Prior to the Introduction of Artemisinin Combination Therapies. Antimicrob Agents Chemother 60(6):3340-7. (2016/05) [Abstract]

Isozumi R, Uemura H, Kimata I, Ichinose Y, Logedi J, Omar AH, Kaneko A. Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum. Emerg Infect Dis 21(3):490-2 (2015/03) [Abstract]

Basuki S, Fitriah, Riyanto S, Budiono, Dachlan YP, Uemura H. Two novel mutations of pfdhps K540T and I588F, affecting sulphadoxine-pyrimethamine-resistant response in uncomplicated falciparum malaria at Banjar district, South Kalimantan Province, Indonesia. Malar J 13:135 (2014/04) [Abstract]

Isozumi R, Uemura H, Le DD, Truong VH, Nguyen DG, Ha VV, Bui QP, Nguyen VT, Nakazawa S. Longitudinal survey of Plasmodium falciparum infection in Vietnam: characteristics of antimalarial resistance and their associated factors. J Clin Microbiol 48(1):70-7 (2010/01) [Abstract]

Rubin-de-Celis SS, Uemura H, Yoshida N, Schenkman S.  Expression of trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole.  Cell Microbiol. 2006 Dec;8(12):1888-98. [Abstract]

Alcantara-Neves NM, Ribeiro-dos-Santos R, Amor AL, Uemura H, Silva-Neto SJ, Eichinger D, Pontes-de-Carvalho L.  Parasite-derived trans-sialidase binds to heart tissue in Trypanosoma cruzi-infected animals. Microb Pathog. 2004 Nov;37(5):273-8. [Abstract]

Nagamune K, Acosta-Serrano A, Uemura H, Brun R, Kunz-Renggli C, Maeda Y, Ferguson MA, Kinoshita T.  Surface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors.  J Exp Med. 2004 May 17;199(10):1445-50. [Abstract]

Ramirez MI, Yamauchi LM, de Freitas LH Jr, Uemura H, Schenkman S.  The use of the green fluorescent protein to monitor and improve transfection in Trypanosoma cruzi. Mol Biochem Parasitol. 2000 Nov;111(1):235-40. [No Abstract]

Saavedra E, Herrera M, Gao W, Uemura H, Pereira MA.  The Trypanosoma cruzi trans-sialidase, through its COOH-terminal tandem repeat, upregulates interleukin 6 secretion in normal human intestinal microvascular endothelial cells and peripheral blood mononuclear cells. J Exp Med. 1999 Dec 20;190(12):1825-36. [Abstract]

Smith LE, Uemura H, Eichinger D.  Isolation and expression of an open reading frame encoding sialidase from Trypanosoma rangeli. Mol Biochem Parasitol. 1996 Jul;79(1):21-33. [Abstract]

Egima CM, Briones MR, Freitas Junior LH, Schenkman RP, Uemura H, Schenkman S.  Organization of trans-sialidase genes in Trypanosoma cruzi. Mol Biochem Parasitol. 1996 May;77(2):115-25. [Abstract]

Uemura H, Schenkman S, Nussenzweig V, Eichinger D.  Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities. EMBO J. 1992 Nov;11(11):3837-44. [Abstract]

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