|Nagasaki Univ Institute of Tropical Medicine Department of Protozoology Kaneko Pf Basic|
|P. FALCIPARUM BASIC VALUES|
|Compiled by Osamu Kaneko, (Dec/16/2009 update)|
|genome|| P. falciparum genome and other organisms
et al Nature 419. 2002 Table 1, partial]
ND, not determined. NA, not available. "# of
genes" for D. discoideum are for chr 2.
|SNPs|| Polymorphism in 204 genes of chromosome 3
et al. Nature 418, 2002 Table 2]
Data from 5 P. falciparum lines (3D7, Dd2, HB3, 7G8, and
|Age|| Speciation between P. falciparum and P. yoelii: 80 - 100 MYA,
coincidencing with the speciation of the primate-rodent lineage (Perkins and
Speciation between P. falciparum and P. reichenowi: 5 - 7 MYA, coincidencing with the speciation of Homo-Pan lineage.
|Speed|| 5.1 x 10-9 substitutions/site/year (Hughes and
The average rate of Syn substitution is about 5.75 - 7.19 substitution/Syn sites/109 Y based on the comparison of P. falciparum and P. yoelii (Castillo-Davis et al, 2004).
Meiotic crossover activity = 17 kb/cM, 5.88 x 10-7 recombination/site/generation (Su et al, 1999)
These "estimates are quite large and of a similar magnitude to those previously reported [Hughes and Verra F, 2001]. These estimates do not support the hypothesis of a severe recent population bottleneck." [Mu et al. Nature 418, 2002] mu is the neutral mutation rate (per gene or per base pair) per generation after [Hughes and Verra F, 2001].
The "effective population size of this species has been of the order of at least 10(5) for the past 300,000-400,000 years." [Hughes AL, Verra F. . Proc. R. Soc. Lond. B 268, 1855–1860 (2001).]
|from KAZUSA DNA Res. Inst, Japan
P. yoelii yoelii
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