English

病理実験ユニット

病理学分野熱帯病を病理学的手法および分子生物学的手法を用いて,主として感染症に関する研究を行う。中でも感染が原因で起る腫瘍の研究を行う。これらの結果,熱帯地域の疾患の治療および予防に貢献することを本分野の目的とする。多くの研究者が炎症を伴った癌の進展に関して,癌の発症メカニズムを提唱しているが,慢性の炎症と癌との関連性についての発症メカニズムは,さらなる研究が望まれている。ゆえに,我々の研究は,感染症により発症する癌の病態をシグナル伝達などに焦点を当てて研究を進めて行く。

スタッフ

  • 助教 千馬正敬

研究活動

感染症による腫瘍について

後進国においては,腫瘍による死亡者の20%から25%が感染症によるものとされている。これに比べて,先進国では,7%から10%が感染症によるものとされている。慢性炎症から腫瘍が発生する関連性については,広く知られている。特に,腫瘍ウイルスと腫瘍の発生についての関連性については,密接であると考えられている。DNAウイルスおよびRNAウイルスの両方ともに腫瘍を発生することが可能であると報告されている。Epstein-Barrウイルス(EBV),ヒト・パピローマウイルス(HPV),B型肝炎ウイルス(HBV),カポジ肉腫関連ヘルペスウイル(KSHV)は,DNAウイルスである。RNAウイルスでは,C型肝炎ウイルスおよびヒトTリンパ球ウイルス(HTLV-1)がある。EBVでは,バーキット・リンパ腫,上咽頭癌,ホジキン・リンパ腫,非ホジキン・リンパ腫などの腫瘍に関連している。HBVおよびHCVは,肝細胞癌に関連している。HTLV-1は,成人T細胞白血病に関連している。HPVは,子宮頚癌,陰茎癌,肛門癌,口腔癌,皮膚癌などに関連している。後進国において,これらの感染症が原因で発症する腫瘍は,全腫瘍の内15%から20%が関係している。さらに5%の腫瘍が細菌感染(Helicobactor pylori)および寄生虫感染症(Schistosoma,Opistorchis,Clonorchis)に関連している。
 組織病理学的に,慢性炎症は,多数のリンパ球およびマクロファージの浸潤が見られる。1863年にウイルヒョウは,リンパ球浸潤を伴った慢性炎症の病変から腫瘍が発生するという仮説を発表した。リンパ球およびマクロファージの活性化は,炎症のメディエーターである,サイトカイン,ケモカイン,成長因子,生存因子などのレセプターと結合して結果的に免疫反応を増幅する。
 感染症および炎症を伴った腫瘍の発生メカニズムは未だ明らかではない。しかしながら,感染症および炎症を伴った腫瘍に関して,多くの腫瘍発生のメカニズムが提唱されている。1)シグナル伝達系:炎症を進展するサイトカインとして,例えば,腫瘍壊死因子(TNF-α),インターロイキン-1(IL-1),IL-6,IL-8,IL-18などとトールライク受容体が,多くの重要なシグナル伝達系の活性化を導く。その他の炎症の遺伝子産物として,間質メタロプトテアーゼ-9(MMP-9),血管内皮成長因子(VEGF),サイクロオキシジンナーゼ-2(COX-2),5-リポオキシジンナーゼ(5-LOX)などがある。NF-κBは,より重要な役割を炎症のなかで担っていることがよく知られている。2)ウイルス・タンパク質と宿主との直接反応:ウイルス・タンパク質とヒト遺伝子との結合によって宿主細胞の変異を導く。腫瘍抑制遺伝子であるレチノブラストーマ・タンパク質およびp53は,ウイルス・タンパク質の産生物によって腫瘍の発生を抑制できなくなる。例えば,HPVのE6およびE7タンパク質は,HPV関連腫瘍の腫瘍発生因子として働く。3)免疫不全:ヒト免疫不全ウイルス(HIV)は,免疫を抑制して,カポジ肉腫および悪性リンパ腫を発生させる。4)活性酸素(ROS)および活性窒素(RNS)の産生:長期にわたる炎症細胞の活性化は,ROSおよびRNSを発生させることによって宿主のDNAに障害を与え,腫瘍発生に寄与する。これらの中でも,NF-κBの活性化は,腫瘍発生および進展に関係している。ゆえに,我々は,慢性炎症を起こす感染症と腫瘍との関連性をシグナル伝達系などの物質の働きに焦点をあてて研究を進めて行く。

主要業績

主要英文著書

  1. Senba M, Mori N. Challenge to threat of invisible transmission: Global health security for outbreak control of emerging infections diseases. Advances in Medicine and Biology. Nova Science Publishers, Inc., New York, 2016; 167-218. eBook
  2. Senba M, Mori N. Challenge to threat of invisible transmission: Global health security for outbreak control of emerging infections diseases. Advances in Medicine and Biology. Nova Science Publishers, Inc., New York, 2016; 167-218. Hardcover Book
  3. Senba M, Mori N. Mechanisms of cancer formation under interplay between host immune and human papillomavirus (HPV) infection. In Watanabe HS. Editor. Horizons in Cancer Research Volume 61. Nova Science Publishers, Inc., New York, 2016; 19-70. eBook
  4. Senba M, Mori N. Mechanisms of cancer formation under interplay between host immune and human papillomavirus (HPV) infection. In Watanabe HS. Editor. Horizons in Cancer Research Volume 61. Nova Science Publishers, Inc., New York, 2016; 19-70, Hardcover Book
  5. Senba M, Mori N. Pathogenesis of Kaposi sarcoma associated with human herpesvirus-8 infection. In: Viktorsson K, editor. Advancements in cancer research. Nova Science Publishers, Inc., New York, 2012; 105-132, eBook
  6. Senba M, Mori N. Pathogenesis of Kaposi sarcoma associated with human herpesvirus-8 infection. In: Viktorsson K, editor. Advancements in cancer research. Nova Science Publishers, Inc., New York, 2012; 105-132, Hardcover Book
  7. Senba M, Watanabe K. Possibility of novel anti-multidrug resistant Pseudomonas aeruginosa strategies using bactericidal activity in Streptococcus sanguinis secretion. In: Mendez-Vilas A, editor. Science against microbial pathogens: Communicating current research and technological advances. Volume 3. Formatix Publisher, Inc., Badajoz, 2011; 706-713, Hardcover Book
  8. Senba M, Mori N, Wada A. Oncogenesis of and the Link Between Inflammation and Cancer Due to Human Papillomavirus (HPV) Infection, and the Forthcoming Eradication for Vaccination and the Development of Vaccine Control Strategies. In: Watanabe HS, editor. Horizons in Cancer Research Volume 44. Nova Science Publishers, Inc., New York, 2011; 85-115. eBook
  9. Senba M, Mori N, Wada A. Oncogenesis of and the Link Between Inflammation and Cancer Due to Human Papillomavirus (HPV) Infection, and the Forthcoming Eradication for Vaccination and the Development of Vaccine Control Strategies. In: Watanabe HS, editor. Horizons in Cancer Research Volume 44. Nova Science Publishers, Inc., New York, 2011; 85-115. Hardcover Book
  10. Senba M, Mori N, Wada A. Outbreak control for emerging, and re-emerging infectious diseases and challenge to threat of invisible transmission. In: Alvintzi P, and Eder H. editors. Crisis Management. 2nd ed., Nova Science Publishers, Inc., New York, 2011; 197-230. eBook
  11. Senba M, Mori N, Wada A. Outbreak control for emerging, and re-emerging infectious diseases and challenge to threat of invisible transmission. In: Alvintzi P, and Eder H. editors. Crisis Management. 2nd ed., Nova Science Publishers, Inc., New York, 2011; 197-230. Hardcover Book
  12. Senba M, Mori N, Wada A. Outbreak control for emerging, and re-emerging infectious diseases and challenge to threat of invisible transmission. In: Alvintzi P, and Eder H. editors. Crisis Management. Nova Science Publishers, Inc., New York, 2010; 159-186. eBook
  13. Senba M, Mori N, Wada A. Outbreak control for emerging, and re-emerging infectious diseases and challenge to threat of invisible transmission. In: Alvintzi P, and Eder H. editors. Crisis Management. Nova Science Publishers, Inc., New York, 2010; 159-186. Hardcover Book
  14. Senba M, Mori N, Wada A: Oncogenesis of human papillomavirus (HPV). In: Tao HE, editor. DNA Tumor Viruses. Nova Science Publishers, Inc., New York, 2009; 75-102. eBook
  15. Senba M, Mori N, Wada A: Oncogenesis of human papillomavirus (HPV). In: Tao HE, editor. DNA Tumor Viruses. Nova Science Publishers, Inc., New York, 2009; 75-102. Hardcover Book

主要英文総説

  1. Senba M, Mori N. Oncogenesis of human papillomavirus (HPV) associated with cancers and host immune responses. Int J Cancer Res Prev, 2016; 9(1): 1-58
  2. Senba M, Mori N. Mechanisms of viral immune evasion lead to development from chronic inflammation to cancer formation associated with human papillomavirus infection. Oncol Rev, 2012; 6(2): 135-144.
  3. Senba M, Kawai K, Mori N. Pathogenesis of metastatic calcification and acute pancreatitis in adult T-cell leukemia under hypercalcemic state. Lukemia Res Treatment, 2012, e128617, 9 pages.
  4. Senba M, Mori N. Pathogenesis of Kaposi sarcoma associated with human herpesvirus-8 infection. Cancer Res J. 2011; 4(2): 101-128.
  5. Senba M, Mori N, Wada A: Oncogenesis and the link between inflammation and cancer due to human papillomavirus (HPV) infection, and the development of vaccine control strategies. Cancer Res J. 2009; 2(4): 307-338.
  6. Senba M, Senba MI: Acute pancreatitis associated with hypercalcemia in adult T-cell leukemia. J Gastroenterol Hepatol, 1996; 11: 180-182.
  7. Senba M, Watanabe M: Safety consideration for human immunodeficiency virus infection in pathology department workers exposed to infected materials and patients. Acta Med Nagasaki, 1991; 36: 83-86.
  8. Senba M: Mechanism of specific and nonspecific reactions in hepatitis B surface antigen staining. Pathol N Lett, 1989, 3: 5-8.

主要英文論文

原著論文 2016

  1. Ishikawa C, Jomori T, Tanaka J, Senba M, Mori N. Peridinin, a carotenoid, inhibits proliferation and survival of HTLV-1-infected T-cell lines. Int J Oncol, 2016, 49: 1713-1721.
  2. Ishikawa C, Senba M, Mori N. Efficiency of AUY922 in mice with adult T-cell leukemia/lymphoma. Oncol Lett, 2016, 12: 387-392.

原著論文 2015

  1. Ishikawa C, Senba M, Mori N. Induction of IB- by Epstein-Barr virus latent membrane protein-1 and CD30. Int J Oncol, 2015 Dec; 47 (6): 2197-2207. doi: 10.3892/ijo.2015.3218. Epub 2015 Oct 22.
  2. Ishikawa C, Senba M, Mori N. Constitutive expression of IRF-5 in HTLV-1-infected T cells. Int J Oncol, 2015 Jul; 47 (1) :3 61-69. doi: 10.3892/ijo.2015.3020. Epub 2015 May 22.
  3. Mori N, Ishikawa C, Senba M. Activation of PKC‑δ in HTLV‑1‑infected T cells. Int J Oncol, 2015 Apr; 46 (4): 1609-1618. doi: 10.3892/ijo.2015.2848. Epub 2015 Jan 26.

原著論文 2014

  1. Tun MM, Aoki K, Senba M, Buerano CC, Shirai K, Suzuki R, Morita K, Hayasaka D. Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus. Sci Rep, 2014 Jun 18; 4: 5344. doi: 10.1038/srep05344.
  2. Adachi K, Nakamura R, Osada Y, Senba M, Tamada K, Hamano S. Involvement of IL-18 in the Expansion of Unique Hepatic T Cells with Unconventional Cytokine Profiles during Schistosoma mansoni Infection. PLoS One, 2014 May 13;9 (5): e96042. doi: 10.1371/journal.pone.0096042. eCollection 2014.

原著論文 2013

  1. Kimura R, Rokkaku T, Takeda S, Senba M, Mori N. Cytotoxic effects of fucoidan nanoparticles against osteosarcoma. Mar Drugs, 2013, 11 (11): 4267-4278.
  2. Ishikawa C, Tanaka J, Katano H, Senba M, Mori N. Hippuristanol reduces the viability of primary effusion lymphoma cells both in vitro and in vivo. Mar Drugs, 2013, 11 (9): 3410-3423.
  3. Kimura R, Senba M, Cutler SJ, Ralph SJ, Xiao G, Mori N. Human T-cell leukemia virus type I Tax-induced IκB-ζ modulates Tax-dependent and -independent gene expression in T cells. Neoplasia, 2013, 15(9): 1110-1124.
  4. Rokkaku T, Kimura R, Ishikawa C, Yasumoto T, Senba M, Kanaya F, Mori N. Anticancer effects of marine carotenoids, fucoxanthin and its deacetylated product, fucoxanthinol, on osteosarcoma. Int J Oncol, 2013; 43: 1176−1186.
  5. Bao LQ, Huy NT, Kikuchi M, Yanagi T, Senba M, Shuaibu MN, Honma K, Yui K, Hirayama K. CD19(+) B cells confer protection against experimental cerebral malaria in semi-immune rodent model. PLoS One, 2013 May 28; 8(5): e64836.
  6. Wada A, Wong PF, Hojo H, Hasegawa M, Ichinose A, Llanes R, Kubo Y, Senba M, Ichinose Y. Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity. Biochem Biophys Res Commun, 2013; 434(2): 223-227.
  7. Ishikawa C, Kawakami H, Uchihara JN, Senba M, Mori N. CD69 overexpression by human T-cell leukemia virus type 1 Tax transactivation. Biochem Biophys Acta - Molecular Cell Research (BBA-Mol Cell Res), 2013; 1833(6): 1542-1552.

原著論文 2012

  1. Shimokawa C, Kabir M, Taniguchi M, Mondal D, Kobayashi S, Ali IK, Sobuz SU, Senba M, Houpt E, Haque R, Petri WA Jr, Hamano S. Entamoeba moshknovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice. J Infect Dis, 2012; 206: 744-751.

原著論文 2011

  1. Nakayama Y, Ishikawa C, Tamaki K, Senba M, Fujita J, Mori N. Interleukin-1α produced by human T-cell leukemia virus type I-infected T cells induces ICAM-1 expression on lung epithelial cells. J Med Microbiol, 2011; 60: 1750-1761.
  2. Ono S, Tanaka T, Ishida M, Kinoshita A, Fukuoka J, Takaki M, Sakamoto N, Ishimatsu Y, Kohno S, Hayashi T, Senba M, Yasunami M, Kubo Y, Yoshida LM, Kubo H, Ariyoshi K, Yoshiura K, Morimoto K. Surfactant protein C G100S mutation causes familial pulmonary in Japanese kindred. Eur Respir J, 2011; 38: 861-869.
  3. Senba M, Buziba N, Mori N, Morimoto K, Nakamura T. Increased prevalence of Kaapisi’s sarcoma-associated herpesvirus in the Kaposi sarcoma-endemic area of Western Kenya in 1981-2000. Acta Virol. 2011; 55: 161-164.
  4. Ichinose A, Watanabe K, Senba M, Ahmed K, Ariyoshi K, Matsumoto K. Demonstration of pneumococcal capsule under immunoelectron microscopy. Acta Med Nagasaki, 2011; 56: 1-4.
  5. Mori N, Ishikawa C, Senba M. Induction of CD69 expression by cagPAI-positive Helicobacter pylori infection. World J Gastroenterol, 2011; 17: 3691-3699.
  6. Mori N, Ishikawa C, Senba M, Kimura M, Okano Y. Effects of AZD1152, a selective Aurora B kinase inhibitor, on Burkitt’s lymphoma and Hodgkin’s lymphoma. Biochem Phermacol, 2011; 81: 1106-1115.
  7. Nakachi S, Nakazato T, Ishikawa C, Sawada S, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N. Human T-cell leukemia virus type 1 Tax transactivates the matrix metalloproteinase 7 gene via JunnD/AP-1 signaling. Biochem Biophys Acta - Molecular Cell Research (BBA-Mol Cell Res), 2011; 1813: 731-741.
  8. Tsumuraya T, Ishikawa C, Machijima Y, Nakachi S, Senba M, Tanaka J, Mori N. Effects of hippuristanol: an inhibitor of eIF4A: on adult T-cell leukemia. Biochem Pharmacol, 2011; 81: 713-722.
  9. Helegbe GK, Yanagi T, Senba M, Huy NT, Shuaibu MN, Yamazaki A, Kikuchi M, Yasunami M, Hirayama K. Histopathological studies in two strains of semi-immune mice infected with Plasmodium berghei ANKA after chronic exposure. Parasitol Res, 2011; 108:807-814.
  10. Ishikawa C, Nakachi S, Senba M, Sugai M, Mori N. Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis. Carcinogenesis. 2011; 32(1): 110-119.
  11. Senba M, Buziba N, Mori N, Fujita S, Morimoto K, Wada A, Toriyama K. Human papillomavirus infection induces NF-kB in cervical cancer: A comparison with penile cancer. Oncol Lett. 2011; 2: 65-68.

ウイルス関連<原著論文> (2010年以前)

  1. Senba M, Mori N, Fujita S, Jutavijittum P, Yousukh A, Toriyama K, Wada A. Relationship among human papillomavirus infection, p16INK4a, p53 and NF-kB activation in penile cancer from northern Thailand. Oncol Lett. 2010; 1: 599-603.
  2. Sawada S, Ishikawa C, Tanji H, Nakachi S, Senba M, Okudaira T, Uchihara JN, Taira N, Oshiro K, Yamada Y, Tanaka Y, Uezato H, Oshima K, Sasai K, Burgering BM, Sunakawa H, Mori N. Overexpression of caveolin-1 in adult T-cell leukemia. Blood, 2010; 115: 2220-2230.
  3. Senba M, Mori N, Wada A, Fujita S, Yasunami M, Irie S, Hayashi T, Igawa T, Kanetake H, Takahara O, Toriyama K. Human papillomavirus genotypes in penile cancers from Japan and HPV induced NF-kB activation. Oncol Lett. 2010; 1: 267-272
  4. Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N. Overexpression of aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kB activity. Int J Cancer, 2009; 124(11): 2607-2615.
  5. Senba M, Buziba N, Mori N, Wada A, Irie S, Toriyama K. Detection of human papillomavirus and cellular regulators p16INK4a, p53, and NF-kB in penile cancer cases in Kenya. Acta Virol, 2009; 53(1): 43-48.
  6. Teruya H, Tomita M, Senba M, Ishikawa C, Tamayose M, Miyazato A, Yara S, Tanaka Y, Iwakura Y, Fujita J, Mori N. Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules. Retrovirology. 2008 Sep 22; 5: 86 (page 1 to 10).
  7. Fujita S, Senba M, Kumatori A, Hayashi T, Ikeda T, Toriyama K. Human papillomavirus infection in oral verrucous carcinoma: genotyping analysis and inverse correlation with p53 expression. Pathobiology. 2008; 75(4): 257-264.
  8. Jutavijittum P, Yousukh A, Samountry B, Samountry K, Ounavong A, Thammavong T, Keokhamphue J, Toriyama K: Seroprevalence of hepatitis B and C virus infections among Lao blood donors. Southeast Asian J Trop Med Public Health, 38: 674-679, 2007
  9. Senba M, Kumatori A, Fujita S, Jutavijittum P, Yousukh A, Morouchi T, Nakamura T, Toriyama K: The prevalence of human papillomavirus genotypes in penile cancers from Northern Thailand. J Med Virol, 78: 1341-1346, 2006
  10. Jutavijittum P, Jiviriyawat Y, Yousukh A, Kunachiwa W, Toriyama K: Genotypes of hepatitis B virus among voluntary blood donors in northern Thailand. Hepatol Res, 35: 263-266, 2006
  11. Takeshita S, Nakamura H, Kawakami A, Fukushima T, Gotoh T, Ichikawa T, Tsujino A, Ida H, Toriyama K, Hayashi T, Eguchi K: Hepatitis B-related polyarteritis nodosa presenting necrotizing vasculitis in the hepatobiliary system successfully treated with lamivudine, plasmapheresis and glucocorticoid. Intern Med, 45: 145-149, 2006
  12. Jutavijittum P, Jiviriyawat Y, Yousukh A, Hayashi S, Toriyama K: Evaluation of a hepatitis B vaccination program in Chiang Mai, Thailand. Southeast Asian J Trop Med Public Health, 36: 207-212, 2005
  13. Ohata K, Hamasaki K, Toriyama K, Ishikawa H, Nakao K, Eguchi K: High viral load is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis B virus infection. J Gastroenterol Hepatol, 19: 670-675, 2004
  14. Fujita S, Buziba N, Kumatori A, Senba M, Yamaguchi A, Toriyama K: Early stage of Epstein-Barr virus lytic infection leading to the "starry sky" Pattern formation in endemic Burkitt lymphoma. Arch Pathol Lab Med, 128:549-552, 2004
  15. Ohata K, Hamasaki K, Toriyama K, Matsumoto K, Saeki A, Yanagi K, Abiru S, Nakagawa Y, Shigeno M, Miyazoe S, Ichikawa T, Ishikawa H, Nakao K, Eguchi K: Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Cancer, 97: 3036-3043, 2003
  16. Mori N, Sato H, Hayashibara T, Senba M, Hayashi T, Yamada Y, Kamihira S, Ikeda S, Yamasaki Y, Morikawa S, Tomonaga M, Geleziunas R, Yamamoto N: Human T-cell leukemia virus type I Tax transactivates the matrix metalloproteinase-9 gene: Potential role in mediating adult T-cell leukemia invasiveness. Blood, 99: 1341-1349, 2002
  17. Jutavijittum P, Jiviriyawat Y, Jiviriyawat W, Yousukh A, Hayashi S, Toriyama K: Present epidemiological pattern of antibody to hepatitis a virus among Chiang Mai children, Northern Thailand. Southeast Asian J Trop Med Public Health, 33: 268-271, 2002
  18. Fukuhara T, Sharp GB, Mizuno T, Itakura H, Yamamoto M, Tokunaga M, Tokuoka S, Cologne JB, Fujita Y, Soda M, Mabuchi K: Liver cancer in atomic-bomb survivors: histological characteristics and relationships to radiation and hepatitis B and C viruses. J Radiat Res (Tokyo), 42: 117-130, 2001
  19. Sharp GB, Cologne JB, Fukuhara T, Itakura H, Yamamoto M, Tokuoka S: Temporal changes in liver cancer incidence rates in Japan: accounting for death certificate inaccuracies and improving diagnostic techniques. Int J Cancer, 93: 751-758, 2001
  20. Senba M, Itakura H: Adult T-cell leukemia-lymphoma associated with metastatic calcification and acute pancreatitis under hypercalcemic condotion. Acta Med Nagasaki, 43: 26-33, 1998
  21. Kusuda M, Toriyama K, Kamidigo NO, Itakura H: A comparison of epidemiologic, histologic, and virologic studies on Hodgkin's disease in western Kenya and Nagasaki, Japan. Am J Trop Med Hyg, 801-807, 1998
  22. Thavarungkul P, Toriyama K, Kusuda M, Kamito H, Kamito M, Nakayama T, Kato Y, Itakura H: Clinico-pathological predictive factors of response to interferon therapy in chronic hepatitis C. Southeast Asian J Trop Med Public Health, 27: 85-90, 1996
  23. Graf J, Toriyama K, Itakura H: A clinico-pathological study of 163 untreated cases of chronic hepatitis C. Rev Soc Bras Med Trop, 29: 21-25, 1996
  24. Rahman SM, Itakura H, Motoda A: Regenerative pattern of liver cells in primary biliary cirrhosis, alcoholic cirrhosis, posthepatitic cirrhosis (HBV-related) and hepatocellular carcinoma: Comparative analysis by computerized morphometry. Pathol Int, 46: 267-273, 1996
  25. Senba M, Zhong XY, Senba MI, Itakura H: EBV and nasopharyngeal carcinoma. Lancet, 343(8905): 1104, 1994
  26. Senba M, Zhong XY, Itakura H: EBNA 2 expression in nasopharyngeal carcinoma. Hum Pathol, 25: 327, 1994
  27. Zhong XY, Senba M, Gu JN, Itakura H: B-cell antigen marker expression on the nasopharyngeal carcinoma. Zentral Pathol, 139: 281-286, 1993
  28. Senba M, Zhong XY, Itakura H: Histopathological difference of nasopharyngeal carcinoma in southern China and Japan. Acta Med Nagasaki, 38: 242-246, 1993
  29. Senba M, Zhong XY, Itakura H: Proliferating cell nuclear antigen (PCNA), nucleolar organizer regions (AgNORs), and mitotic indeces in nasopharyngeal carcinoma. Acta Med Nagasaki, 38: 200-205, 1993
  30. Senba M, Zhong XY, Itakura H: T-cell rich B-cell cross-reacting nasopharyngeal carcinoma. Acta Med Nagasaki, 38: 189-192, 1993
  31. Senba M, Zhong XY, Itakura H: Immunohistochemical investigation of nasopharyngeal carcinoma using keratin, EMA, laminin, fibronectin, collagen type IV, laminin receptor, and laminin/collagen receptor antibodies. Acta Med Nagasaki, 38: 182-185, 1993
  32. Senba M, Nakamura T, Senba MI, Watanabe M, Zhong XY, Itakura H: Long-term trend of decresing frequency of hepatitis B virus infection. Acta Virol, 37: 199-201, 1993
  33. Senba M, Kawai K, Senba MI: Adult T-cell leukemia-lymphoma (ATLL) associated with acute pancreatitis due to hypercalcemia. Acta Med Nagasaki, 37: 37-39, 1992
  34. Senba M: Prevention of chronic carriage of hepatitis B virus infection in Ethiopian immigrants. Isr J Med Sci, 28: 308, 1992
  35. Senba M, Kawai K: Hypercalcemia and production of parathyroid hormone-like protein in adult T-cell leukemia-lymphoma. Eur J Hematol, 48: 278-279, 1992
  36. Senba M, Kawai K, Toda Y, Takahara O: Pathogenesis of metastatic calcification due to hypercalcemia in adult T-cell leukemia-lymphoma. Acta Med Nagasaki, 36: 22-26, 1991
  37. Senba M: Adult T-cell leukemia associated with acute pancreatitis under hypercalcemic conditions. Am J Med, 91: 445-446, 1991
  38. Senba M, Kawai K: Metastatic calcification due to hypercalcemia in adult T-cell leukemia-lymphoma (ATLL). Zentralbl Pathol, 137: 341-345, 1991
  39. Senba M, Nakamura T, Kawai K, Senba MI: HTLV-1 and acute pancreatitis. Lancet, 337 (8755): 1489, 1991
  40. Senba M, Baba S: Immunohistochemical localization of hepatitis B core antigen in the bile duct epithelia. Acta Med Nagasaki, 35: 88-91, 1990
  41. Senba M, Kawai K, Chiyoda S, Takahara O: Metastatic liver calcification in adult T-cell leukemia-lymphoma associated with hypercalcemia. Am J Gastroenterol, 85: 1202-1203, 1990
  42. Senba M, Kawai K: Iron accumulation in hepatocellular carcinoma and the role of hepatitis B core antigen. Acta Med Biol, 38: 37-39, 1990
  43. Senba M, Nakamura T: Long-term trend of decreasing frequency of hepatitis B virus infection in hepatitis, cirrhosis, and hepatocellular carcinoma. Acta Med Nagasaki, 34: 246-249, 1989
  44. Senba M, Kawai K: Iron accumulation and presence of hepatitis B core antigen in hepatocellular carcinoma in hemochromatotic liver. Acta Med Nagasaki, 34: 188-190, 1989
  45. Senba M: Relationship between iron accumulation and portal fibrosis. Isr J Med Sci, 25: 650, 1989
  46. Senba M, Yamashita H, Itakura H: Localization of hepatitis B surface antigen in the pancreas and lymph node. Jpn J Trop Med Hyg, 17: 273-276, 1989
  47. Senba M, Nakamura T, Itakura H: Relationships among iron accumulation, cirrhosis, and hepatitis B virus infection in Bantu siderosis. Ann Soc Belg Med Trop, 69: 77-78, 1989
  48. Senba M, Matsumura H, Nakamura T, Itakura H: Histochemical and immunohistochemical studies on the relationship between iron accumulation and liver cell injury. Acta Med Nagasaki, 33:68-71, 1988
  49. Senba M, Itakura H: Eosinophilic globules in fibroadipose tissue adjacent to Kaposi's sarcoma. Zentralbl Allg Pathol, 134: 485-487, 1988
  50. Senba M, Nakamura T: ATL opportunistic infections. Am J Surg Pathol, 12:578, 1988
  51. Senba M, Nakamura T, Toda T, Matsumura H: Decreasing frequency, with time, of hepatitis B surface antigen positive liver biopsy in hepatitis, cirrhosis, and hepatocellular carcinoma. Lancet, i (8585): 588-589, 1988
  52. Senba M, Itakura H: A staining method for easy detection of eosinophilic globules in Kaposi's sarcoma. Tohoku J Exp Med, 152: 209-210, 1987
  53. Senba M, Nakamura T, Itakura H: Decrease trend in proportions of hepatitis B surface antigen carrier in chronic hepatitis, cirrhosis, and cirrhosis with hepatocellular carcinoma. Jpn J Trop Med Hyg, 15: 25-28, 1987
  54. Inoue O, Itakura H, Toriyama K, Satoh A, Furukawa R, Kusumoto Y, Ishii N, Koji T, Nagataki S: Ultrastructural study of lymphocytic interaction with hepatocytes and endothelial cells in acute non-A, non-B hepatitis. Acta Pathol Jpn, 37: 207-212, 1987
  55. Itakura H, Toriyama K, Uzuta F, Irifune K, Toda Y, Senba M: Kaposi's sarcoma: Pathology and local epidemiology in Kenya. Trop Med, 28(Suppl): 3-8, 1986
  56. Toda T, Hokama S, Toda Y, Senba M, Itakura H: Arterial viral infection in restricted-ovulator chickens with endogenous hyperlipidemia. Trop Med, 28: 251-260, 1986
  57. Senba M, Itakura H, Yamashita H, Huang HJ: Eosinophilic globules in Kaposi's sarcoma: A histochemical, immunohistochemical, and ultrastructural study. Acta Pathol Jpn, 36: 1327-1333, 1986
  58. Senba M, Terao H, Nakamura T, Itakura H: Histological analysis of relationship between iron accumulation and liver cell injury: Problem in hepatic toxicity caused by Bantu siderosis. Lab Clin Pract, 4: 89-95, 1986
  59. Senba M: Autofluorescence of eosinophilic substances. In reply. Arch Pathol Lab Med, 110: 93, 1986
  60. Inoue O, Nagataki S, Itakura H, Iida F, Shimizu Y, Yano M, Shikata T, Tandon BN: Liver morphology in marmosets infected with epidemic non-A, non-B hepatitis in India. Liver, 6: 178-183, 1986
  61. Senba M, Nakamura T, Itakura H: Statistical analysis of relationship between iron accumulation and hepatitis B surface antigen. Am J Clin Pathol, 84: 340-342, 1985
  62. Senba M: Autofluorescence of eosinophilic globules in Kaposi's sarcoma. Arch Pathol Lab Med, 109: 703, 1985
  63. Senba M, Itakura H: Electron microscope observation of eosinophilic globules in Kaposi's sarcoma. Trop Med, 27: 113-117, 1985
  64. Senba M, Toda Y, Itakura H, Watanabe A: Analysis of orcein dye for hepatitis B surfacen antigen staining by using thin layer chromatography and mechanism of non-specific reactions. Trop Med, 27: 9-12, 1985
  65. Inoue O: Morphological studies on the mechanism of hepatocellular injury during acute phase of infection in marmosets inoculated with hepatitis A virus. Acta Pathol Jpn, 35: 1319-1331, 1985
  66. Toda Y, Senba M, Itakura H: Further histological study of the role of hepatitis B infection on the development of hepatocellular carcinoma. Trop Med, 26: 123-136, 1984
  67. Senba M, Nakamura T, Itakura H: Statistical analysis of relationship between hepatitis B surface antigen, cirrhosis, and hepatocellular carcinoma. Trop Med, 26: 117-122, 1984
  68. Senba M: New procedure of connective tissue staining and its application to the liver diagnosis in histologic sections. Okajimas Folia Anat Jpn, 61: 167-171, 1984
  69. Senba M: Histologic staining methods for hepatitis B surface antigen (HBsAg) and interpritation of dye reactions in vitro. Acta Histochem Cytochem, 17: 241-249, 1984
  70. Senba M, Toriyama K, Uzuta F, Itakura H: Periodic acid Schiff (PAS) and phosphotungstic acid hematoxylin (PTAH) positive materials in cutaneous type of Kaposi's sarcoma. Trop Med, 26: 87-91, 1984
  71. Senba M: New differentiating solution for hepatitis B surface antigen staining method. Am J Clin Pathol, 79: 647-648, 1983
  72. Senba M: Orcein stain. The author's reply. Am J Clin Pathol, 78: 573, 1982
  73. Senba M: Staining method for hepatitis B surface antigen (HBsAg) and its mechanism. Am J Clin Pathol, 77: 312-315, 1982
  74. Asano M, Kato H, Yoshimoto K, Seyama S, Itakura H, Hamada T, Iijima S: Primary liver carcinoma and liver cirrhosis in atomic bomb survivors, Hiroshima and Nagasaki, 1961-75, with special reference to hepatitis B surface antigen. J Natl Cancer Inst, 69: 1221-1227, 1982

細菌関連<原著論文> (2010年以前)

  1. Wada A, Hasegawa M, Wong PF, Shirai E, Shirai N, Tan L, Llanes R, Hojo H, Yamasaki E, Ichinose A, Ichinose Y, Senba M. Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralized its toxin activity. Glycobiology. 2010; 20: 668-678.
  2. Watanabe K, Senba M, Ichinose A, Yamamoto T, Ariyoshi K, Mastumoto K. Bactericidal activity in filtrated supernatant of Streptococcus sanguis against multidrug-resistant Pseudomonas aeruginosa. Tohoku J Exp Med, 2009 Oct; 219 (2): 79-84.
  3. Takeshima E, Tomimori K, Teruya H, Ishikawa C, Senba M, D’Ambrosio D, Kinjo F, Mimura H, Sasakawa C, Hirayama T, Fujita J, Mori N. Helicobacter pylori-induced interleukin-12 p40 expression. Infect Immun, 2009 Apr; 77: 1337-1348.
  4. Takeshima E, Tomimori K, Kawakami H, Ishikawa C, Sawada S, Tomita M, Senba M, Kinjo F, Mimuro H, Sasakawa C, Fujita J, Mori N. NF-kB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65. BMC Microbiol, 2009 Feb 12; 9: 36 (page 1 to 9).
  5. Tomimori K, Uema E, Teruya H, Ishikawa C, Okudaira T, Senba M, Yamamoto K, Matsuyama T, Kinjo F, Mori N: Helicobacter pylori induced CCL20 expression. Infect Immun, 75: 5223-5232, 2007
  6. Kurita S, Koyama J, Onizuka S, Motomura K, Watanabe H, Watanabe K, Senba M, Apicella MA, Murphy TF, Yoneyama H, Matsushima K, Nagatake T, Oishi K.: Dynamics of dendritic cell migration and the subsequent induction of Protective immunity in the lung after repeated airway challenges by nontypeable Haemophilus influenzae outer membrane protein. Vaccine, 24:5896-5903, 2006
  7. Amano H, Morimoto K, Senba M, Wang H, Ishida Y, Kumatori A, Yoshimine H, Oishi K, Mukaida N, Nagatake T: Essential contribution of monocyte chemoattractant protein-1/C-C chemokine ligand-2 to resolution and repair processes in acute bacterial pneumonia. J Immunol, 172: 398-409, 2004
  8. Mori N, Sato H, Hayashibara T, Senba M, Geleziunas R, Wada A, Hirayama T, Yamamoto N: Helicobacter pylori induces matrix metalloproteinase-9 through activation of nuclear factor kappaB. Gastroenterology, 124: 983-992, 2003
  9. Mitsushima H, Oishi K, Nagao T, Ichinose A, Senba M, Iwasaki T, Nagatake T: Acid aspiration induces bacterial pneumonia by enhanced bacterial adherence in mice. Microb Pathog, 33: 203-210, 2002
  10. Satoh S, Oishi K, Iwagaki A, Senba M, Akaike T, Akiyama M, Mukaida N, Matsushima K, Nagatake T: Dexamethazone impairs pulmonary defense against Psudomonas aeruginosa partially through iNOS gene repression in mice. Clin Exp Immunol, 26: 266-273, 2001
  11. Morimoto K, Amano H, Sonoda F, Baba M, Senba M, Yoshimine H, Yamamoto H, Ii T, Oishi K, Nagatake T: Alveolar macrophages that phagocytose apoptotic neutropils produce hepatocyte growth factor during bacterial pneumonia in mice. Am J Respir Cell Mol Biol, 24: 608-615, 2001
  12. Amano H, Oishi K, Sonoda F, Senba M, Wada A, Nakagawa H, Nagatake T: Role of cytokine-induced neutrophil chemoattarctanta-2 (CINC-2) a in a rat model of chronic bronchopulmonary infections with Psudomonas aeruginosa. Cytokine, 12: 1662-1668, 2000
  13. Amano H, Yamamoto H, Senba M, Oishi K, Suzuki S, Fukushima K, Mukaida N, Matsushima K, Eguchi K, Nagatake T: Impairment of endotoxin-induced macrophage inflammatory protein 2 gene expression in alveolar macrophages in streptozotocin-induced diabets in mice. Infect Immun, 68: 2925-2929, 2000
  14. Watanabe M, Kiyohara T, Murata K, Yodoi J, Itakura H: Cholera toxin inhibits lethal hit stage of natural killer cell-mediated cytotoxicity. Microbiol Immunol, 37: 317-323, 1993
  15. Senba M, Toda Y, Yamashita H: Black thyroid associated with minocycline therapy : Histochemical and ultrastructural studies on the brown pigment. Isr J Med Sci, 24:51-53, 1988
  16. Toriyama K, Uzuta F, Senba M, Itakura H, Kamidigo NO: Rhinoscleroma in western Kenya: Report of three cases with characteristic features. Trop Med, 28: 241-249, 1986
  17. Senba M, Fukushima N, Toda T: A rapid silver staining method for identification of Mycobacterium leprae in histologic sections. Tohoku J Exp Med, 150: 363-364, 1986
  18. Senba M, Irifune K, Kaku M: Rapid identification of Klebsiella pneumoniae in the lung tissue by fluorescence microscopy. Tohoku J Exp Med, 149: 341-342, 1986
  19. Senba M, Irifune K, Kaku M: A new application for Klebsiella pneumoniae staining. Am J Clin Pathol, 82: 378, 1984

真菌関連<原著論文> (2010年以前)

  1. Yousukh A, Jutavijittum P, Pisetpongsa P, Chitapanarux T, Thongsawat S, Senba M, Toriyama K: Clinicopathologic study of hepatic Penicillium marneffei in Northern Thailand. Arch Pathol Lab Med, 128: 191-194, 2004
  2. Senba M, Watanabe K: Arachis hypoaea (PNA) lectin binding affinity to Candida parapsilosis in histologic sections. Acta Med Nagasaki, 37: 29-31, 1992
  3. Senba M, Watanabe K, Yoshida K, Ochi S, Matsumoto K, Yano K, Itakura H: Endocarditis caused by Candida parapsilosis. Southeast Asian J Trop Med Public Health, 23: 138-141, 1992
  4. Senba M: Detection of fungi in tissue sections using peroxidase-labeled lectins. Acta Med Nagasaki, 35: 74-76, 1990
  5. Senba M, Kawai K: Autofluorescence of Tricosporon beigelii. Revista Lar-amer Microbiol, 31: 131-132, 1989
  6. Senba M, Toda T, Toda Y, Hokama S: A reliable differentiation of mucor from aspergillus in tissue sections with ultraviolet illumination. Acta Med Nagasaki, 34:147-148, 1989
  7. Senba M: Lectin histochemistry of fungi. Arch Pathol Lab Med, 113: 327-328, 1989
  8. Senba M: Fluorescence of mucormycosis. Am J Clin Pathol, 90: 229, 1988
  9. Senba M, Yamashita H: Autofluorescence of Rhinosporidium seeberi. Am J Clin Pathol, 83: 132, 1985

原虫関連<原著論文> (2010年以前)

  1. Senba M: Double staining method for identification of cyst walls and intracystic bodies of Pneumocystis carinii in histologic sections. Acta Med Nagasaki, 34: 32-34, 1989
  2. Senba M: Prevention of explosion of used ammoniacal silver solution. Arch Pathol Lab Med, 111: 504, 1987
  3. Senba M: A selective silver staining method for identification of Pneumocystis carnii in histologic sections. Jpn J Parasitol, 34: 525-526, 1985
  4. Senba M: A reliable silver staining method for identification of Pneumocystis carinii in histologic sections. Tohoku J Exp Med, 143: 397-404, 1984
  5. Senba M, Itakura H, Yamashita H: Preventive method for possible explosion of used ammoniacal silver nitrate solution: Treatment of waste fluid derived from histopathological staining. Trop Med, 26: 93-96, 1984
  6. Senba M: A reliable silver staining method for Pneumocystis carinii and reticulum fibers in histologic sections. Acta Histochem Cytochem, 16: 169-171, 1983

寄生虫関連<原著論文> (2010年以前)

  1. Shigeno S, Fujimaki Y, Toriyama K, Ichinose A, Mitsui Y, Aoki Y, Kimura E: Temporary shift of microfilariae of Brugia pahangi from the lungs to muscles in Mongolian jirds, Meriones unguiculatus, after a single injection of diethylcarbamazine. J Parasitol, 92: 1075-1080, 2006
  2. Watanabe K, Kikuchi M, Ohno A, Mohamed RT, Nara T, Ubalee R, Senba M, Iwasaki T, Chen H, Aoki Y, Hirayama K: The miniature pig: a unique experimental model for Schistosoma japonicum infection. Parasitol Int, 53: 293-299, 2004

その他の論文

  1. Suzuki S, Honma K, Matsuyama T, Suzuki K, Toriyama K, Akitoyo I, Yamamoto K, Suematsu T, Nakamura M, Yui K, Kumatori A: Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha-dendritic cell development. Proc Natl Acad Sci U S A, 101: 8981-8986. 2004
  2. Rahman SM, Itakura H: Morphometry in histopathology. An image analysis workstation for the pathology laboratory. Anal Quant Cytol Histol, 18: 471-480, 1996
  3. Zhong XY, Senba M, Chen YX, Nishigami T, Miyaji H: The role of laminin on cultured human glioma cell proliferation and metastasis in nude mice and rats. Acta Med Nagasaki, 38: 164-167, 1993
  4. Zhong XY, Senba M, Situ R, Chen YX: Malignant transformation of cultured low grade glioma cells: An immunohistochemical and ultrastructural study. Acta Med Nagasaki, 38: 79-82, 1993
  5. Senba M, Zhong XY, Itakura H, Matsuo T: Alveolar hemorrhage associated with glomerulonephritis so-called pulmonary renal (goodpasture's) syndrome. Acta Med Nagasaki, 38: 49-53, 1993
  6. Toda T, Tamamoto T, Kiyuna M, Shingaki Y, Ono I, Uchima H, Kunishima N, Senba M, Itakura H: Comparative pathological studuy of coronary arteriosclerosis in Okinawa, Nagasaki, and Akita prefectures. Acta Med Nagasaki, 36:146-152, 1991
  7. Senba M, Watanabe M: Beta-subunit of human chorionic gonadotropin in malignant lymphoma: An immunohistochemical study. Acta Med Nagasaki, 36:50-52, 1991
  8. Senba M, Watanabe M: Ectopic production of the beta-subunit of human chorioic gonadotropin in malignant lymphoma. Zentralbl Pathol, 137: 402-404, 1991
  9. Kawai K, Baba K, Senba M, Nakamura T, Doi Y, Yamaguchi T, Hashiba K, Tsuchiyama H: Effect of the adrenal inhibitor trilostane on the morphology of the adrenocortical cells of Dahl salt-sensitive and Dahl salt-resistant rats. Int J Exp Pathol, 72:451-462, 1991
  10. Matsumura H, Suematsu T, Senba M: Freeze-fracture replica studies of the tight junctions in the normal rat pulmonary epithelium. Med Electron Microsc, 23:930-931, 1990
  11. Senba M: Autofluorescent substances as control specimens. Hum Pathol, 21: 353-354, 1990
  12. Mwinymtwana AM, Toriyama K, Eto H, Komuro S, Senba M, Itakura H: Relationship between histopathology in cirrhosis of the liver with or without hepatocellular carcinoma and esophageal varix formation. Trop Med, 32: 7-15, 1990
  13. Kawai K, Senba M, Tagawa T, Suzuki K, Matsuo T, Tsuchiyama H: Osteoclast-type giant cell tumor of the endometrium: An immunohistochemical study. Zentralbl Allg Pathol, 135: 743-749, 1989
  14. Senba M, Kawai K: Nature of yellow-brown bodies: Histochemical and ultrastructural studies on the brown pigments. Zentralbl Allg Pathol, 135: 351-355, 1989
  15. Senba M, Kawai K: Immunohistochemical reactivity of phagocytic and non-phagocytic histiocytes in lymph nodes with lyzozyme, alpha-1-antichymotrypsin, S-100 protein, alkaline phosphatase, and acid phosphatase. Okajimas Folia Anat Jpn, 66: 61-68, 1989
  16. Senba M, Kawai K: Adenoma-cancer sequence using carcinoembryonic antigen in colorectal adenoma with early invasive carcinoma. Acta Med Biol, 36: 103-107, 1989
  17. Kawai K, Senba M, Shigematsu K, Irie J, Yoshida K, Nakatani A, Kamio T, Kanetake H, Saito Y, Tsuchiyama H: Histochemical nature of eosinophilic globules in phochromocytoma of adrenal medulla. Acta Med Nagasaki, 33: 189-192, 1988
  18. Senba M, Kawai K, Matsumura H: Immunohistochemical characteristics of histiocytes in lymph node associate with yellow-brwon bodies. Acta Med Nagasaki, 33:124-126, 1988
  19. Kawai K, Senba M, Tsuchiyama H: Eosinophilic globules in pheochromocytoma of the adrenal medulla: A histochemical, immunohistochemical, and ultrastructural study. Acta Pathol Microbiol Immunol Scand, 96: 911-916, 1988
  20. Senba M: More on large intracytoplasmic bodies. Am J Clin Pathol, 90: 119-120, 1988
  21. Senba M: Staining properties of melanin and lipofuscin pigments. Am J Clin Pathol, 86: 556, 1986
  22. Senba M, Irifune K, Uehara Y: Anomalous origin of the left coronary artery from the pulmonary artery (The Bland-White-Garland syndrome). Okajimas Folia Anat Jpn, 62: 205-209, 1985
  23. Senba M: Autofluorescence of lipofuscin granules ? Am J Clin Pathol, 83: 134, 1985
  24. Yamashita H, Nakayama I, Moriuchi A, Yokoyama S, Mochizuki Y, Itakura H, Senba M: A giant cell tumor of pancreas: A tumor of acinal cell origin. Trop Med, 24: 203-208, 1983

研究分野トップへ戻る»