Japanese

Department of Virology

Department of VirologyThis Department has been conducting basic and applied research on arthropod-borne viruses (arboviruses) such as Japanese encephalitis virus (JEV), dengue virus (DENV), Zika virus, Chikungunya virus (CHIKV) and severe fever with thrombocytopenia virus (SFTSV).

Members

  • Professor Kouichi Morita
  • Associate Professor Moi Meng Ling
  • Associate Professor Shingo Inoue
  • Assistant Professor Takeshi Nabeshima
  • Assistant Professor Mya Myat Ngwe Tun
  • Visiting Professor Masanobu Ago
  • Visiting Researcher Toru Kubo
  • Visiting Researcher Yuki Takamatsu
  • Visiting Researcher Reo Uchida
  • Assistant Kazumi Jodai
  • Assistant Hiroko Kawabata
  • Assistant Kimiko Taniguchi
  • Graduate student Aung Kyaw Kyaw
  • Graduate student Phu Ly Minh Huong
  • Graduate student Bui Thu Thuy
  • Graduate student Luz Mark Anthony
  • Graduate student Nguyen Co Thac
  • Graduate student Tsuyoshi Ando

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Activities

Molecular epidemiology of arboviruses

We isolate DENV, JEV and CHIKV in Asia and African regions and conduct molecular epidemiological analysis to clarify international and inter-continental movement of these viruses. We also analyze unique genome sequences that are relevant to pathogenicity.

Research o n vaccine development using reverse genetics

We have developed DENV infectious clones and identified viral determinants by modifying various parts of the genes. We are currently developing genetically engineered viruses as candidates for live attenuated DENV vaccines by financial support of GHIT.

Research on the pathogenicity of arboviruses and evaluation of therapeutic compounds using animal model

We elucidate the mechanism of pathogenicity and infectivity of arboviruses, such as DENV and SFTSV by using a mouse model.

Development of rapid diagnostic assay for infectious diseases

Various rapid diagnostics are being developed for arboviruses using PCR, LAMP, LC/MS and Immuno-chromatographic technologies for the detection of viral genome, protein and specific antibodies.

Activities as a WHO Collaborating Center

he department is designated as a WHO Collaborating Center for Reference and Research on Tropical Viral Diseases since 1993 and currently our department has been re-designated as a center for Tropical and Emerging Virus Diseases. The center has been collaborating with WHO in training WHO fellows from many developing countries and has deployed experts as WHO short-term consultants.

         Recent main research achievement
1. Ngwe Tun et al. Am J Trop Med Hyg 2018;98:868-871.
2. Ly et al. BMC Infect Dis 2018;18:31.
3. Bui et al. J Gen Virol 2018;99:1044-1057.
4. Raekiansyah et al. Arch Virol 2018;163:1649-1655.
5. Moi et al. Lancet Infect Dis 2017;17:805-806.

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