Japanese

Department of Molecular Infection Dynamics

The Department of Molecular Infection Dynamics, in cooperation with Department of Exploratory Research for Drug Discovery aim to identify drug target molecules and to establish screening systems in order to find lead compounds with potential use for treatment, prophylaxis and transmission blocking against malaria.

Members

  • Associate Professor Ken Daniel Inaoka
  • Assistant Professor Takaya Sakura
  • Research Fellow Eri Yoshida
  • Research Fellow Hyo Yuki
  • Assistant Miyuki Kasai
  • Assistant Masaharu Eriguchi

Activities

This Department conduct research on microaerophilic metabolism conserved in several pathogens such as parasites (protozoa and helminth) and bacteria, in order to understand the molecular mechanism of parasitism phenomena.

We utilize multidisciplinary approaches, consisted by biochemistry, molecular biology, biophysics, structural biology and chemical biology, to conduct our basic and applied research.

Our target infectious diseases include protozoan parasites such as Plasmodium spp., Theileria spp., Trypanosoma cruzi, T. brucei and Leishmania spp.; helminthes such as Ascaris suum, Anisakis spp., Haemonchus contortus and Fasciola spp., and bacterial pathogens such as Mycobacterium spp、and Helicobacter pylori.

We also conduct research on cancer. Intestinal parasites have evolved sophisticated machinery to adapt and survive in hypoxic and nutrient deprived environment (microenvironment). Certain type of cancer cells also possess similar machinery to survive under tumor microenvironment.

Our activities are supported by research grants acquired from KAKENHI (MEXT), AMED, GHIT and Private Companies.

         Recent main research achievement
1. Araki et al. Proc Natl Acad Sci USA 2019;116(17):8269-8274.
2. Shiba et al. Biochim Biophys Acta Bioemerg 2019;1860(5):375-382.
3. Matsubayashi et al. Genes 2019;10(1):E29.
4. Miyazaki et al. Front Pharmacol 2018;9:997.
5. Ebiloma et al. Eur J Med Chem 2018;150:385-402.

Return to Top of Shionogi Global Infectious Diseases Division»