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Department of Pediatric Infectious Diseases

Department of Pediatric Infectious Diseases

The Department of Pediatric Infectious Diseases conducts research on a wide range of infectious diseases with special attention on severe pediatric infectious diseases including pneumonia, diarrhea, dengue and malaria. Our research interests include integration of clinical, environmental and social issues at global, national and local levels.

Members

  • Professor Masahiro Hashizume
  • Professor Laymyint Yoshida
  • Assistant Professor Michiko Toizumi
  • Assistant Professor Mizuki Takegata
  • Assistant Professor Keisuke Yoshihara
  • Assistant Professor Mohammad Shah
  • Assistant Professor Lina Madaniyazi
  • Visiting Associate Professor Yeonseung Chung
  • Visiting Associate Professor Aurelio Tobias
  • Visiting Research Fellow Chisato Imai
  • Visiting Research Fellow Yoonhee Kim
  • Visiting Research Fellow Chihiro Iwasaki
  • Visiting Research Fellow Shinya Tsuzuki
  • Assistant Mayumi Nakano
  • Assistant Nozomi Oka
  • Assistant Setsuko Hirakura
  • Assistant Takashi Okada
  • Graduate student Naohiko Matsushita
  • Graduate student Saki Tanaka
  • Graduate student Atsushi Fujioka
  • Graduate student Hironori Nishikawa
  • Graduate student Paul Lester Carlos Chua
  • Graduate student Noriko Kitamura
  • Graduate student Muhammad Abdul Basit Bin Ahmad Tajudin
  • Graduate student Wambugu Peris Wanjiru

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Activities

Environmental epidemiology: health impacts of cliamte change

Our research interests extend over a range of issues in environmental epidemiology. The current research topics, which we work in collaboration with both the international and Japanese colleagues, focus mainly on the health impacts of atmospheric environmental changes including climate variability, global climate change and transboundary and local air pollution in high-, middle- and low-income countries. Ongoing projects include:

  1. Short-term association between ambient temperature (heat, heat extremes and cold) and mortality in Japan and other parts of the world.
  2. Effects of ocean-atmosphere interaction phenomenon and local weather on vector-born, water-born and other infectious diseases in tropical and sub-tropical settings.
  3. Development of malaria early warning system in Southern Africa.
  4. Health effects of local and transboundary air pollution in Japan and in the East and Southeast Asia.
  5. Respiratory health effects of the different chemical composition of airborne particulate matter and the sources.
         Recent main research achievement
1. Chung et al. Environ Health Perspect 2018;126(5):057002.
2. Matsushita et al. PLoS Negl Trop Dis 2018;12(4):e0006331.
3. Kim et al. Environ Health Perspect 2018;126(3):037002.
4. Kim et al. Environ Health Perspect 2017;125(7):077005.
5. Gasparrini et al. Lancet 2015;386(9991):369‒375.

Clinical Epidemiological Studies of Pediatric Infectious Disease in Nha Trang, Vietnam

The Department of Pediatric Infectious Diseases conducts research on a wide range of infectious diseases with special attention on severe pediatric infectious diseases including pneumonia, diarrhea, and dengue which are the major causes of under 5 mortality.

  • Cohort studies on Pediatric Infectious Diseases in Vietnam: We receive funding from the Japan Initiative for Global Research Network on Infectious Diseases (JGRID), Japan Agency for Medical Research and Development (AMED) to conduct a large population based cohort study on Pediatric Infectious Diseases in Nha Trang, central Vietnam since 2006.

  • Pediatric ARI surveillance: A population based hospitalized Pediatric ARI surveillance at Khanh Hoa General Hospital, Nha-Trang, Vietnam was established to determine incidence, etiology and risk factors for pediatric ARI/pneumonia since 2007. We also investigate the emergence of new viruses and its molecular and clinical importance. In addition, we also investigate the impact or potential of various vaccine introduction on pneumonia and dengue in a population level.

  • Birth cohort study: We are also conducting a birth cohort study on 2000 new born babies in Nha Trang, Vietnam since 2009. This study was conducted to study congenital infection and host genetic factors on physical-neurological development of the child and development of SPID.

  • Pneumococcal conjugate vaccine (PCV) reduced dosing trial: We received a multimillion dollar grant from Bill and Melinda Gates Foundation to conduct a PCV reduce dosing trial in Vietnam. We believe that the study outcome will change global PCV vaccination strategy to improve the availability of PCV and other vaccines in developing countries.

  • Dengue intra-family transmission in the community: In collaboration with London School of Hygiene and Tropical Medicine, we are conduction a dengue intra-family transmission study in the community in Nha Trang. We identify dengue index cases by screening fever cases and followed up their family members for dengue transmission. We also conduct community IgG/M dengue survey in the community to determine yearly dengue infection in the community. These data will be used for future intervention studies to control dengue in the community.

         Recent main research achievement
1. Do et al. Jpn J Infect Dis 2017;70(6):621-627.
2. Shi et al. Lancet 2017;390(10098):946-958.
3. Yoshihara et al. Sci Rep 2016;16;6:27856.
4. Flasche et al. Vaccine 2014;32(51):6963-6970.
5. Toizumi et al. Pediatrics 2014;134(2):e519-26.

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