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Department of Parasitology

parasitology Infectious diseases are still a huge menace to human health and continue unabated in tropical areas under the conditions of poverty and the unique natural and social environments. Various kinds of parasites infect humans for long periods of time without killing them, giving rise to tremendous social and/or economic loss. We would like to develop deep insight into parasitic diseases and the surrounding factors from various points of view through both field and laboratory studies. Our goal is to contribute to new knowledge and to provide an enthusiastic environment for the training of the future generation of investigators.

Schistosoma mansoni

Members

  • Professor   Shinjiro Hamano
  • Assistant Professor   Yoshinori Mitsui
  • Assistant Professor   Kentaro Kato
  • Assistant Professor   Risa Sonoda
  • Visiting Scientist(PD)   Sachiyo Nagi
  • Technologist   Megumi Hamasaki
  • Assistant   Hiromi Oda
  • Assistant   Yasuko Kawabata
  • Assistant   Fumie Hara
  • Graduate Student   Shumpei Kambe
  • Graduate Student   Ken-ichi Nobusue
  • Graduate Student   Taeko Moriyasu
  • Graduate Student   Sharmina Deloer
  • Graduate Student   Evans Asena Chadeka
  • Graduate Student   Musa Abu Mohamed
  • Graduate Student   Khanjada Shahnewaj Bin Mannan
  • Graduate Student   Mitsuko Hasegawa
  • Undergraduate Student   Mayako Murata

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Activities

We have been carrying out both field and laboratory studies on several of the most important helminthic diseases, including schistosomiasis, filariasis and intestinal helminthiasis and on important but neglected protozoan diseases such as amoebiasis, leishmaniasis and trypanosomiasis.

Schistosomiasis and Filariasis

We have been researching parasitic diseases in Mbita and Kwale, Kenya, in cooperation with Kenya Medical Research Institute (KEMRI). In the laboratory, we maintain Schistosoma mansoni and intermediate snails and are trying to elucidate immune responses as well as to develop ideal diagnostic methods through the study on the unique molecules belonging to Schistosoma spp.
We set up lymphatic filariasis and neglected tropical disease unit (LF-NTD Unit) together with Prof. Kazuyo Ichimori, so as to contribute to the activities toward Global Program to Eliminate LF and NTD by WHO. In the laboratory, Brugia malayi, B. pahangi and Aedes aegypti are maintained.

Amoebiasis, Leishmaniasis, Trypanosomiasis etc.

Cohort studies on amoebiasis and leishmaniasis are carried out in cooperation with the International Centre for Diarrheal Disease Research, Bangladesh (ICDDR, B.) and the University of Virginia. Field sites include Dhaka and rural areas of Bangladesh. In the laboratory, we study host defense mechanisms against Leishmania major, L. donovani, Trypanosoma cruzi, and in the process, have elucidated the function of the IL-12 cytokine family such as IL-27/WSX-1 during infection. After we developed animal models of intestinal amoebiasis together with Prof. Houpt at University of Virginia, we elucidated the pathogenicity of Entamoeba moshkovskii, and now are devoting ourselves to the study on molecular basis of pathogenicity of and host defense mechanisms to E. histolytica.

Cohort study using HDSS on infectious diseases in Mbita and Kwale area in Kenya

We carried out cross-sectional study on infectious diseases in Mbita and Kwale area using HDSS (Health and Demographic Surveillance System) as the collaboration with Niigata University and Department of Eco-epidemiology. In 2011, the feasible studies on shistosomiasis, other helminthic and protozoan infections, HIV/AIDS, tuberculosis and so on were launched.

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