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Department of Parasitology

parasitologyVarious kinds of parasites infect humans for long periods of time without killing them, giving rise to tremendous afflictions, social and/or economic loss. We would like to develop deep insight into parasitic diseases and the surrounding factors from various points of view through both field and laboratory studies.
Our goal is to contribute to new knowledge and to provide an enthusiastic environment for the training of the future generation of investigators.

Schistosoma mansoni

Members

  • Professor   Shinjiro Hamano
  • Visiting Professor   Dinesh Mondal
  • Visiting Professor   Sammy Njenga
  • Visiting Professor   Abhay Satoskar
  • Assistant Professor   Yoshinori Mitsui
  • Assistant Professor   Risa Nakamura
  • Research Fellow   Mitsuko Hasegawa
  • Research Fellow   Mio Tanaka
  • Research Fellow   Musa Abu Mohamed
  • Research Fellow   Jean Pierre Kambala Mukendi
  • Technologist   Megumi Hamasaki
  • Assistant   Hiromi Oda
  • Assistant   Yasuko Kawabata
  • Assistant   Chiaki Hisata
  • Graduate Student   Shumpei Kambe
  • Graduate Student   Ken-ichi Nobusue
  • Graduate Student   Evans Asena Chadeka
  • Graduate Student   Khanjada Shahnewaj Bin Mannan
  • Graduate Student   Keith Kiplangat Talaam
  • Graduate Student   Eman Abdelazeen Abuelmafa Mousa (South Valley University)
  • Graduate Student   Miho Sassa
  • Medical Student   Jo Ishii

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Activities

We have been researching parasitic diseases in Mbita Kenya, in cooperation with Kenya Medical Research Institute (KEMRI) and Maseno University. In 2017, we have just started a new project on schistosomiasis with the support from MEXT Grant-in-Aid for Scientific Research ( A). We are trying to develop ideal diagnostic methods with the support from Global Health Innovative Technology Fund (GHIT). In the laboratory, we maintain Schistosoma mansonoi, its intermediate snail, Brugia malayi, B. pahangi and Aedes aegypti. In 2017, we have just started “DeWorm3 ” project in Japan which is supported by the Bill & Melinda Gates Foundation as a collaboration with the Natural History Museum, London.

We study host defense mechanisms against Leishmania spp, and in the process, have elucidated the function of the IL-12 cytokine family such as IL-27/WSX-1 during infection. We initiated developing the live attenuated vaccine to leishmaniasis by editing a gene using CRISPR-Cas9 system with the support from GHIT in 2015. In addition, we developed animal models of intestinal amoebiasis together with Prof. Houpt at University of Virginia, we elucidated the pathogenicity of Entamoeba monshkovskii, and now are devoting ourselves to the study on molecular basis of pathogenicity of E. histolytica and host defense mechanisms to it.

         Recent main research achievement
1. Moriyasu et al. PLOS Negl Trop Dis 2018;12(1):e0006197.
2. Deloer et al. Parasitol Int 2017;66(6):817-823.
3. Chadeka et al. PLOS Negl Trop Dis 2017;11(9):e0005872.
4. Mi-ichi et al. PLOS Pathog 2016;12(10):e1005845.
5. Kalenda et al. Parasitol Int 2015;64(6):503-512.

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