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Department of Immunogenetics

Department of ImmunogeneticsThis department is focusing on the pathogenic genetic factors of the host and the parasite in the most important tropical infectious diseases by using immunology and genetics.

Members

  • Professor Kenji Hirayama
  • Associate Professor Nguyen Huy Tien (Clinical Product Development)
  • Senior Assistant Professor Mihoko Kikuchi
  • Assistant Professor Cherif Mahamoud Sama
  • Assistant Professor Syusaku Mizukami (Clinical Product Development)
  • Assistant Professor Shyam Prakash Dumre
  • Technologist Tetsuo Yanagi (NBRC)
  • Assistant Kiyoko Sato
  • Assistant Michiko Fukuda
  • Assistant Yumeko Yoshitsugu
  • Visiting Researcher Mbanefo Evaristus Chibunna
  • Graduate Student Vasquez Velasques, Clara Aleiandra
  • Graduate Student Dao Huy Manh
  • Graduate Student Farhana Mosaddeque
  • Graduate Student Mathenge Peterson Gitonga
  • Graduate Student Maiko Akashi
  • Graduate Student Avenido Eleonor Fundan
  • Graduate Student Kota Mochizuki
  • Graduate Student Miho Inoguchi
  • Graduate Student Awet Alem Teklemichael

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Activities

To clarify the molecular mechanisms in the protective and/ or pathogenic host response to human pathogens such as Dengue Virus, Malaria, Trypanosoma cruzi and Schistosoma, the following research projects are going on in our laboratory.

Malaria

  1. Genetic analysis of malaria endemicity
  2. Vaccine development
    * Py Transamidase (TAM) vaccine with nanoparticle delivery system

Schistosomiasis

  1. Vaccine and Drug target molecules identification by genomics and proteiomics
    * SEA motif bearing gene family

Chagas disease

  1. Genetic susceptibility to different clinical types of chronia Chagas disease, namely, indeterminate, cardiac, and digestive forms
    * HLA-B14 haplotype as resistant against chronic complications
  2. Host and Parasite factors influencing on the reactivity to the chemotherapy in the paediatric patients with chronia Chagas Disease. On going
  3. Compound library screening by using in vitro culture of T.cruzi
    * Astellas open innovation network including U.Tokyo, Tokyo Institute of Technology, AIST(National Institute of Advanced Industrial Science and Technology), and DNDi

Dengu fever

  1. Pathogenesis of the DHF(Dengue Hemorrhagic Fever)
    * HLA, Mast Cell derived factors, related to severity
  2. Early stage predictors for severe Dengue fever
    * Free DNA, Chymase, VEGF ATⅢ

Collaborations:

The research here is performed based on the well-arranged collaborative projects with the following facilities.
1. Malaria: Karolinska Institute (Sweden), Kenya Medical Research Institute (KEMRI). London School of Hygiene and Tropical Medicine, University of Liverpool.
2. Schistosmiasis: Jiangxi Provincial Institute of Parasitic Diseases (China), Jiangsu Provincial Institute of Parasitic Disease (China), RITM (Philippines).
3. Chagas Disease: Center of Tropical Medicine, Sirani Clinic, and Hospital Japones (Bolivia), IICS University of Asuncion (Paraguay).
4. Dengue Fever: Ho Chi Minh Pasteur in Vietnam, Pasteur Paris, McMaster University.

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