Japanese

Department of Immunogenetics

Department of ImmunogeneticsThis department primarily focuses on the fundamental insights of the pathogenic genetic factors of the host and the pathogens of tropical infectious diseases such as Dengue fever, malaria and Chagas disease, through the application of immunology and genetics. With the understanding of the dynamic host-pathogen interactions, we are further concerned with the development of new tools to fight against these diseases including novel therapeutics (drugs) or vaccines.

Members

  • Professor Kenji Hirayama
  • Professor (Concurrent) Katsuyuki Yui
  • Visiting Associate Professor Nguyen Huy Tien (TMGH)
  • Associate Professor Shusaku Mizukami (Immune Regulation)
  • Senior Assistant Professor Mihoko Kikuchi
  • Assistant Professor Shyam Prakash Dumre
  • Research Fellow Vasquez Velasques, Clara Aleiandra (TMGH)
  • Research Fellow Farhana Mosaddeque
  • Research Fellow Mathenge Peterson Gitonga
  • Research Fellow Taeko Naruse
  • Visiting Researcher Yukimi Katagami
  • Assistant Yasuko Mukae
  • Assistant Yoko Hosoi
  • Graduate Student Pembi Emmanuel
  • Graduate Student Maiko Akashi
  • Graduate Student Kota Mochizuki
  • Graduate Student Yuki Tayama
  • Graduate Student Awet Alem Teklemichael
  • Graduate Student Yu Michimuko
  • Graduate Student Bundutidi Mavinga Gloria
  • Graduate Student Tran Quang Thach
  • Graduate Student Ines Maria Iglesias Rodriguez
  • Graduate Student Alina Angelica Acosta Cabello

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Activities

We strive to build a highly interactive and collaborative network for sustainable research activities, and hence, we have various well-arranged collaborative projects with the following overseas and domestic facilities. 1) Research Institute for Tropical Medicine (RITM), Philippines. 2) UAGRM, Bolivia, 3) IICS University of Asuncion, Paraguay, 4) Pasteur Institute in HoChiMinh City, and National Institute of Hygiene and Epidemiology (NIHE), Vietnam, 5) Ahmadu Bello University, Nigeria, 6) Pasteur Paris, France, 7) London School of Hygiene and Tropical Medicine, UK, 8) National Institutes of Health (NIH), USA, 9) Tokyo Medical and Dental University, 10) Toyama University, 11) The National Institute of Advanced Industrial Science and Technology (AIST) Following ongoing research projects are going on.

Malaria

  1. NGS analysis of Host and Malaria genome (KEKENHI)
  2. Vaccine development (Shionogi)
  3. Anti-malarial drug development (AMED, Toyama)

Chagas disease

  1. Early bio-markers identification for chronic Chagas disease, namely, indeterminate, cardiac, and digestive forms in Bolivia (KAKENHI)
  2. Host and parasite factors influencing on the reactivity to the chemotherapy (KAKENHI)
  3. Exploring the essentiality of amastigote-stage specific metabolic pathways in Trypanosoma cruzi utilizing CPISPR/Cas9 system (GHIT)
  4. Anti-trypanosomal drug development (Toyama, Nagasaki)

Dengu fever

  1. Identification and validation of early stage predictors for Severe Dengue (J-GRID)
  2. Mechanism of cellular immunity on protection against Dengue virus (J-GRID)
         Recent main research achievement
1. Phuong et al. Ann Clin Microbiol Antimicrob 2019;13;18(1):10.
2. Giang et al. Rev Med Virol 2018;28(6):e2005.
3. Manh et al. J Gen Virol 2018;99(9):1239-1247.
4. Tani et al. J Med Chem 2018;61(14):6399.
5. Bui et al. J Gen Virol 2018;99(8):1044-1057.

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