Japanese

Department of Clinical Medicine

Department of Clinical MedicineThis is the only clinical department in NEKKEN, which has clinical activities in Nagasaki University Hospital. We conduct a wide range of multi-disciplinary studies linking our strength of clinical epidemiology to laboratory-based microbiology and immunology studies both in- and outside Japan. Our main research interests are respiratory infectious diseases, tuberculosis (TB), HIV/AIDS and tropical infectious diseases. Specific research activities are described as follows:

Members

  • Professor Koya Ariyoshi
  • Associate Professor Konosuke Morimoto
  • Assistant Professor Motoi Suzuki
  • Assistant Professor Hikaru Sato
  • Assistant Professor Yoshiro Yamashita
  • Visiting Researcher Michio Yasunami
  • Visiting Researcher Masahiko Mori
  • Visiting Researcher Taisuke Nakaura
  • Assistant Rina Shiramizu
  • Assistant Kyoko Uchibori
  • Assistant Yumi Hamasaki
  • Assistant Hitomi Nakamura
  • Assistant Satsuki Shiraishi
  • Graduate student Tohru Ogasawara
  • Graduate student Reiko Miyahara
  • Graduate student Nobuo Saito
  • Graduate student Ikumi Sawada
  • Graduate student Satoshi Kakiuchi
  • Graduate student Tomoko Ishifuji
  • Graduate student Ngo Chi Cuong
  • Graduate student Emi Kitashoji
  • Graduate student Hiroshi Fujii
  • Graduate student Shungo Kato
  • Graduate student Hiroyuki Ito
  • Graduate student Kenichi Nobusue
  • Graduate student Hirotomo Yamanashi
  • Graduate student Kentaro Hayashi
  • Graduate student Eiichiro Sando
  • Graduate student Tomoko Hiraoka

Activities

Respiratory Infections Diseases

We have developed multiplex-PCR assays to identify 19 different viral and bacterial respiratory pathogens and also developed a novel nanofluidic real time PCR-based assay to determine 50 pneumococcus serotypes. These molecular assays are now being applied for several clinical studies including a multi-center epidemiological study for adult pneumonia in all over Japan and childhood acute respiratory infection study in central Vietnam. We already finished enrollment of adult pneumonia in Japan and collected around 4,000 cases. A paper of the general epidemiology of adult pneumonia has been published using data of first year. In 2009, we commenced a birth cohort studies, recruiting approximately 2,000 pairs of mothers and new-born babies, which facilitates studies of host-gene polymorphisms associating the severity of pediatric infectious diseases. For the development of a novel treatment strategy, we also investigate the pathogenesis of treatment-refractory pneumonia at molecular levels focusing on macrophage function, of clearing apoptotic cells from the inflammation site.

Tuberculosis

For better-diagnosis of latent MTB infection and tuberculosis, we are analyzing cellular immune responses to various TB antigens using a intra-cellular cytokine staining to evaluate a range of cytokines profile in various stages of TB infection and their contact cases both in Japan. Our goal is to clarify TB-specific cellular immune responses characteristic to a different clinical stage of TB infection. We also investigated pathogens causing bacterial pneumonia and its impact on the survival prognosis of TB patients admitted to the National Infectious Diseases Hospital (San Lazaro Hospital) in the Philippines.

Clinical Research in Infectious Disease Hospitals in the tropics

In collaboration with National Institute of Infectious Diseases, Tokyo, we are conducting undiagnosed febrile illness study in the Department of Infectious Diseases, Bac Mai Hospital, Hanoi, Vietnam by applying diagnostic tests for leptospirosis and various richettial diseases. In collaboration with the San Lazaro Hospital, the Philippines, we are conducting leptospirosis study to evaluate the new diagnostic test and to improve clinical management. We have established a new laboratory of microbiology in the San Lazaro Hospital to make further progress in research of infectious diseases. We also coordinate a bed-side clinical training course on tropical infectious.

HIV Cohort Studies in Northern Thailand

In collaboration with National Institute of Health, Thailand, we conducted a cohort study targeting HIV-infected individuals and their spouses in Lampang Hospital, northern Thailand between July 2000 and December 2010; nearly 2000 people participated. The main objectives of this cohort are to understand mechanisms of resistance to HIV infection among HIV-exposed but uninfected spouses living with HIV-infected patients and mechanisms of slow-progression among HIV-infected slowprogressors. Data and sample analysis are still continuing as collaboration between Thai counter parts and international experts in hostgene polymorphisms, molecular immunology, molecular epidemiology and virology.

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