Activities

Blood stage of malaria parasite invades human erythrocytes and proliferates by creating its own cellular environment. This process includes formations of complex membrane structures inside erythrocyte cytoplasm and transportations of parasite proteins to erythrocyte membrane. Studying this host cell modifications is essential in Plasmodium falciparum research, that often induces sever forms of malaria. We believe that unveiling the molecular mechanisms of structural and chemical balance of parasitized erythrocytes allows us to find important information to discover a new drugtarget. We search molecular factors that are involved in ‘intelligent interior design’ by parasites, and aim to find new antimalarial drug targets and compounds which prevents transition to server malaria. Our research has been merging advantages of classical biochemistry/cellular biology and biophysical approaches. High-resolution imaging, lipidomics, protein chemistry, high-throughput screening for inhibitor compounds have been actively used to achieve our goal. We share our data and collaborate with other three laboratories for advance experiments for fortifying our scientific competence.