Cellular Architecture Studies

Shionogi Global Infectious Diseases Division Shionogi Global Infectious Diseases Division was established in April 2019, through the collaboration agreement between Shionogi & Co., LTD. and Nagasaki University to tackle malaria. Four laboratories, Departments of Cellular Architecture Studies, Molecular Infection Dynamics, Immune Regulation, and Exploratory Research for Drug Discovery get together in the same laboratory space and team up for our mission to find new drug and vaccine candidates by taking advantages of expertise from each department. This is the unique but powerful collaboration that expands our scientific potential and flexibility.

Members

Professor
Fuyuki Tokumasu
Assistant Professor
Shinya Miyazaki
Research Fellow
Junpei Fukumoto
Research Fellow
Ben-Yeddy Abel Chitama
Research Fellow
Kanoko Iki
Research Fellow
Minako Yoshida
Research Fellow
Ryuta Ishii
Research Fellow
Satoshi Miyagawa
Assistant
Moe Tanaka
Assistant
Eiko Sanefuji

Activities

Blood stage of malaria parasite invades human erythrocytes and proliferates by creating its own cellular environment. This process includes formations of complex membrane structures inside erythrocyte cytoplasm and transportations of parasite proteins to erythrocyte membrane. Studying this host cell modifications is essential in Plasmodium falciparum research, that often induces sever forms of malaria. We believe that unveiling the molecular mechanisms of structural and chemical balance of parasitized erythrocytes allows us to find important information to discover a new drugtarget. We search molecular factors that are involved in ‘intelligent interior design’ by parasites, and aim to find new antimalarial drug targets and compounds which prevents transition to server malaria. Our research has been merging advantages of classical biochemistry/cellular biology and biophysical approaches. High-resolution imaging, lipidomics, protein chemistry, high-throughput screening for inhibitor compounds have been actively used to achieve our goal. We share our data and collaborate with other three laboratories for advance experiments for fortifying our scientific competence.

Recent main research achievement

  1. Iso-o et al. Front Cell Dev Biol 2021;9:749153.
  2. Tokumasu et al. Exp Parasitol 2021;83:102369.
  3. Tanaka et al. Biol Open 2019;8:bio042259.
  4. Shindou et al. J Biol Chem 2017;292:12054-12064.
  5. Tokumasu et al. Biol Open 2014;3(6):529‒541.

Achievement list