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- Mashima H, Suzuki J, Hirayama T, Yoshikumi Y, Ohno H, Ohnishi H, Yasuda H, Fujita T, Omata M. Involvement of VAMP7 in Human Gastric Epithelial Cell Vacuolation Induced by Helicobacter pylori-produced VacA. (2008) Infect Immun. In press
- Hisatsune J, Nakayama M, Isomoto H, Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, Yamasaki E, Yahiro K, Moss J, Hirayama T.: Molecular characterization of Helicobacter pylori VacA-induction of IL-8 in U937 cells reveals a prominent role for p38MAP kinase in ATF-2, CREB and NF-kB activation. (2008) J Immunol. 180: 5017-5027.
- Katagata Y, Hirayama T.:Unexpected expression of Hsp47, Q1 a replacement of one amino acid (Val 7 Leu) in the amino terminal region, in cultured human tumorigenic cell lines. (2008) J Dermatol. Sci. 49:33-38.
- Hisatsune J, Yamasaki E, Nakayama M, Shirasaka D, Kurazono H, Katagata Y, Inoue H, Han J, Sap J, Yahiro K, Moss J, Hirayama T.:Helicobacter pylori VacA enhances PGE2 production through induction of COX-2 expression via a p38 MAP kinase/ATF-2 cascade in AZ-521 cells. (2007) Infect. Immun. 75:4472-4481.
- Nakayama M, HisatsuneJ, YamasakiE, NishiY, WadaA, KurazonoH, Sap J, YahiroK, Moss J, Hirayama T: Helicobacter pylori VacA clustering in lipid rafts, mediated by receptor, RPTPƒÀ, is required for intoxication in AZ-521 cells. (2006) Infect Immun. 74: 6571-6580
- Isomoto H.,Urata M, Kawazoe K, Matsuda J, Nishi Y, Wada A, Ohnita K, Hirakata Y, Matsuo N, Inoue K, Hirayama T, Kamihira S, Kohno S. Endoscope disinfection using chlorine dioxide in an automated washer-disinfector. (2006) J. Hosp. Infect. 63: 298-305
- Yamasaki E., Wada A., Kumatori A., Nakagawa I., Funao J., Nakayama M., Hisatsune J., Kimura M., Moss J., Hirayama T. Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic protein Bax, leading to cytochrome c release and cell death, independent of vacuolation (2006) J. Biol. Chem. 281: 11250-11259
- Yahiro K, Shirasaka D, Tagashira M, Wada A, Morinaga N, Kuroda F, Choi O, Inoue M, Aoyama N, Ikeda M, Hirayama T, Moss J, Noda M. Inhibitory effects of polyphenols on gastric injury by Helicobacter pylori VacA toxin. (2005) Helicobacter. 10:231-239
- Isomoto H, Mukae H, Ishimoto H, Nishi Y, Wen CY, Wada A, Ohnita K, Hirayama T, Nakazato M, Kohno S. High concentrations of human beta-defensin 2 in gastric juice of patients with Helicobacter pylori infection. (2005) World J Gastroenterol. 11; 4782-4787.
- Suzuki Y, Gabazza EC, Imoto I, James RF, Hirayama T, Wada A, Horiki N, Nakamura M, Inoue H, Kuroda M, Ogura A, Taguchi Y, Yano Y, Taguchi O, Suzuki K, Adachi Y. Vacuolating cytotoxin A is associated with increased thrombin generation in gastric mucosa. (2005) Helicobacter. 10:323-331
- De Guzman, B.B., Hisatsune, J., Nakayama, M., Yahiro, K., Wada, A., Yamasaki, E., Nishi, Y., Yamazaki, S., Azuma, T., Ito, Y., Ohtani, M., van der Wijk, T., den Hertog, J., Moss, M., Hirayama T.: Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPa and RPTPb, by Helicobacter pylori m2VacA. (2005) Cellular Microbiology. 7:1285-1293
- Wada, A., Hirayama, T., Aburatani, H., Hatakeyama, M.: Functional antagonism between Helicobacter pylori CagA and VacA in control of the NFAT signaling pathway in gastric epithelial cells. (2005) Proc. Natl. Acad. Sci. USA. . 102:9661-9666
- Wada A, Wang AP, Isomoto H, Satomi Y, Takao T, Takahashi A, Awata S, Nomura T, Fujii Y, Kohno S, Okamoto K, Moss J, Millan JL, Hirayama T.: Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin. (2005) Int J Med Microbiol. 294:427-435
- Nishi Y, Isomoto H, Mukae H, Ishimoto H, Wen CY, Wada A, Ohnita K, Mizuta Y, Murata I, Hirayama T, Nakazato M, Kohno S.Concentrations of alpha- and beta-defensins in gastric juice of patients with various gastroduodenal diseases. (2005) World J Gastroenterol. 11:99-103
- Chiba S, Sugiyama T, Yonekura K, Tanaka S, Matsumoto H, Fujii N, Yokota S, Hirayama T.: An antibody to VacA of Helicobacter pylori in the CSF of patients with Miller-Fisher syndrome. (2004) Neurology. 63:2184-2186
- Vora P, Youdim A, Thomas LS, Fukata M, Tesfay SY, Lukasek K, Michelsen KS, Wada A, Hirayama T, Arditi M, Abreu MT: Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. (2004) J Immunol. 173:5398-405
- Yahiro, K., Wada, A., Yamasaki, E., Nakayama, M., Nishi, Y., Hisatsune, J., Morinaga, N., Sap, J., Noda, M., Moss, J., Hirayama, T.: Essential domain of receptor tyrosine phosphatase b, RPTPb, for interaction with Helicobacter pylori vacuolating cytotoxin. (2004) J. Biol. Chem. 279: 51013-51021
- Isomoto, H., Mukae, H., Ishimoto, H., Date, Y., Nishi, Y., Inoue, K., Wada, A., Hirayama, T., Nakazato, M., Kohno S.: Elevated concentrations of a-defensins in gastric juice of patients with Helicobacter pylori Infection. (2004) Am. J. Gastroenterol. 99:1916-1923
- Harada, K., Ohba, K., Ozaki, S., Isse, K., Hirayama, T., Wada, A., Nakanuma, Y.: Peptide antibiotic human b-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree. (2004) Hepatology 40: 925-932
- Ogushi, K., Wada, A., Niidome, T., Okuda, T., Llanes, R., Nakayama, M., Nishi, Y., Kurazono, H., Smith, K.D., Aderem, A., Moss, J., Hirayama T.:Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC-induction of human b-defensin-2 expression in Caco-2 cells. (2004) J. Biol. Chem.279:12213-12219
- Kawahara, T., Kuwano, Y., Teshima-Kondo, S., Takeya, R., Sumimoto, H., Kishi, K., Tsunawaki, S., Hirayama, T., Rokutan, K.: Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to toll-like receptor 5 signaling in large intestinal epithelial cells. (2004) J. Immunol. 172, 3051-3058
- Nakayama, M., Kimura, M., Wada, A., Yahiro, K., Ogushi, K., Niidome, T., Fujikawa, A., Shirasaka, D., Aoyama, N., Kurazono, H., Noda, M., Moss, J., Hirayama, T.: Helicobacter pylori VacA activates the p38/ATF-2-mediated signal pathway in AZ-521 cells. (2004) J. Biol. Chem. 279,7024-7028
- Mori, N., Krensky, A.M., Geleziunas, R., Wada, A., Hirayama, T., Sasakawa, C., Yamamoto, N.: Helicobacter pylori induces RANTES through activation of NF-kappa B. Infect Immun. (2003) 71:3748-3756
- Suzuki, J., Ohnishi, H., Wada, A., Hirayama, T., Ohno, H., Ueda,. N, Yasuda, H., Iiri, T., Wada, Y., Futai, M., Mashima, H.: Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA. J. Biol. Chem. (2003) 278:25585-25590
- Mori, N., Sato, H., Hayashibara, T., Senba, M., Geleziunas, R., Wada, A., Hirayama, T., Yamamoto, N.: Helicobacter pylori induces matrix metalloproteinase-9 through activation of nuclear factor kappaB. Gastroenterology (2003);124:983-992
- Yahiro, K., Wada, A., Nakayama, M., Kimura, T., Ogushi, K., Niidome, T., Aoyagi, H., Yoshino, K.I., Yonezawa, K., Moss, J., Hirayama, T.: Protein tyrosine phosphatase a, RPTPa, is a Helicobacter pylori VacA receptor. (2003) J. Biol. Chem. 278:19183-19189
- Fujikawa, A., Shirasaka, D., Yamamoto, S., Ota, H., Yahiro, K., Fukada, M., Shintani, T., Wada, A., Aoyama, N., Hirayama, T., Fukamachi, H., Noda, M.: Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. (2003) Nat. Genet. 33:375-381
- Kimura, T., Wada, A., Nakayama, M., Ogushi, K., Nishi, Y., de Guzman, B.B., Moss, J., Hirayama, T.: High molecuolar weight factor in FCS inhibits Helicobacter pylori VacA-binding to its receptor, RPTPb, on AZ-521. (2003) Microbiol. Immnol. 47:105-107
- Shirasaka, D., Aoyama, N., Sakashita, M., Kuroda, K., Maekawa, S., Wambura, C.M., Miyamoto, M., Tamura, T., Yahiro, K., Wada, A., Kurazono, H., Hirayama, T., Kasuga, M.: Relationship between gastric ulcer and Helicobacter pylori VacA detected in gastric juice using bead-ELISA method (2002) Helicobacter 7:281-286
- Paone G, Wada A, Stevens LA, Matin A, Hirayama T, Levine RL, Moss J.: ADP ribosylation of human neutrophil peptide-1 regulates its biological properties. (2002) Proc. Natl. Acad. Sci. USA. 99:8231-8235.
- Ohsaki M, Okuda T, Wada A, Hirayama T, Niidome T, Aoyagi H, :In Vitro Gene Transfection Using Dendritic Poly(L-Lysine). (2002) Bioconjugate Chem. 13:510-517
- Supajatura, V., Ushio, H., Wada, A., Yahiro, K., Okumura, K., Ogawa, H., Hirayama, T., Ra, C.: VacA, a vacuolating cytotoxin of Helicobacter pylori directly activates mast cells for migration and production of pro-inflammatory cytokines. (2002) J. Immunology 22:2603-2606