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  1. Mashima H, Suzuki J, Hirayama T, Yoshikumi Y, Ohno H, Ohnishi H, Yasuda H, Fujita T, Omata M. Involvement of VAMP7 in Human Gastric Epithelial Cell Vacuolation Induced by Helicobacter pylori-produced VacA. (2008) Infect Immun. In press
  2. Hisatsune J, Nakayama M, Isomoto H, Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, Yamasaki E, Yahiro K, Moss J, Hirayama T.: Molecular characterization of Helicobacter pylori VacA-induction of IL-8 in U937 cells reveals a prominent role for p38MAP kinase in ATF-2, CREB and NF-kB activation. (2008) J Immunol. 180: 5017-5027.
  3. Katagata Y, Hirayama T.:Unexpected expression of Hsp47, Q1 a replacement of one amino acid (Val 7 Leu) in the amino terminal region, in cultured human tumorigenic cell lines. (2008) J Dermatol. Sci. 49:33-38.
  4. Hisatsune J, Yamasaki E, Nakayama M, Shirasaka D, Kurazono H, Katagata Y, Inoue H, Han J, Sap J, Yahiro K, Moss J, Hirayama T.:Helicobacter pylori VacA enhances PGE2 production through induction of COX-2 expression via a p38 MAP kinase/ATF-2 cascade in AZ-521 cells. (2007) Infect. Immun. 75:4472-4481.
  5. Nakayama M, HisatsuneJ, YamasakiE, NishiY, WadaA, KurazonoH, Sap J, YahiroK, Moss J, Hirayama T: Helicobacter pylori VacA clustering in lipid rafts, mediated by receptor, RPTPƒÀ, is required for intoxication in AZ-521 cells. (2006) Infect Immun. 74: 6571-6580
  6. Isomoto H.,Urata M, Kawazoe K, Matsuda J, Nishi Y, Wada A, Ohnita K, Hirakata Y, Matsuo N, Inoue K, Hirayama T, Kamihira S, Kohno S. Endoscope disinfection using chlorine dioxide in an automated washer-disinfector. (2006) J. Hosp. Infect. 63: 298-305
  7. Yamasaki E., Wada A., Kumatori A., Nakagawa I., Funao J., Nakayama M.,  Hisatsune J., Kimura M., Moss J., Hirayama T. Helicobacter pylori vacuolating  cytotoxin induces activation of the proapoptotic protein Bax, leading to  cytochrome c release and cell death, independent of vacuolation (2006) J.  Biol. Chem. 281: 11250-11259
  8. Yahiro K, Shirasaka D, Tagashira M, Wada A, Morinaga N, Kuroda F, Choi  O, Inoue M, Aoyama N, Ikeda M, Hirayama T, Moss J, Noda M. Inhibitory effects  of polyphenols on gastric injury by Helicobacter pylori VacA toxin. (2005)  Helicobacter. 10:231-239
  9. Isomoto H, Mukae H, Ishimoto H, Nishi Y, Wen CY, Wada A, Ohnita K, Hirayama  T, Nakazato M, Kohno S. High concentrations of human beta-defensin 2 in gastric  juice of patients with Helicobacter pylori infection. (2005) World J Gastroenterol.  11; 4782-4787.
  10. Suzuki Y, Gabazza EC, Imoto I, James RF, Hirayama T, Wada A, Horiki N,  Nakamura M, Inoue H, Kuroda M, Ogura A, Taguchi Y, Yano Y, Taguchi O, Suzuki  K, Adachi Y. Vacuolating cytotoxin A is associated with increased thrombin  generation in gastric mucosa. (2005) Helicobacter. 10:323-331
  11. De Guzman, B.B., Hisatsune, J., Nakayama, M., Yahiro, K., Wada, A., Yamasaki,  E., Nishi, Y., Yamazaki, S., Azuma, T., Ito, Y., Ohtani, M., van der Wijk,  T., den Hertog, J., Moss, M., Hirayama T.: Cytotoxicity and recognition of  receptor-like protein tyrosine phosphatases, RPTPa and RPTPb, by Helicobacter  pylori m2VacA. (2005) Cellular Microbiology. 7:1285-1293
  12. Wada, A., Hirayama, T., Aburatani, H., Hatakeyama,  M.: Functional antagonism between Helicobacter pylori CagA and  VacA in control of the NFAT signaling pathway in gastric epithelial cells.  (2005) Proc. Natl. Acad. Sci. USA. . 102:9661-9666
  13. Wada A, Wang AP, Isomoto H, Satomi  Y, Takao T, Takahashi A, Awata S, Nomura T, Fujii Y, Kohno S, Okamoto  K, Moss J, Millan JL, Hirayama T.: Placental and intestinal alkaline phosphatases  are receptors for Aeromonas sobria hemolysin.  (2005) Int J Med Microbiol. 294:427-435
  14. Nishi Y, Isomoto H, Mukae H, Ishimoto H, Wen CY, Wada A, Ohnita K, Mizuta  Y, Murata I, Hirayama T, Nakazato M, Kohno S.Concentrations of alpha- and  beta-defensins in gastric juice of patients with various gastroduodenal diseases.  (2005) World J Gastroenterol. 11:99-103
  15. Chiba S, Sugiyama T, Yonekura K, Tanaka S, Matsumoto H, Fujii N, Yokota  S, Hirayama T.: An antibody to VacA of Helicobacter pylori in the CSF of  patients with Miller-Fisher syndrome. (2004) Neurology. 63:2184-2186
  16. Vora P, Youdim A, Thomas LS, Fukata M, Tesfay SY, Lukasek K, Michelsen  KS, Wada A, Hirayama T, Arditi M, Abreu MT: Beta-defensin-2 expression  is regulated by TLR signaling in intestinal epithelial cells. (2004) J Immunol.  173:5398-405
  17. Yahiro,  K., Wada, A., Yamasaki, E., Nakayama, M., Nishi, Y., Hisatsune, J., Morinaga,  N., Sap, J., Noda, M., Moss, J., Hirayama, T.: Essential domain of receptor  tyrosine phosphatase b, RPTPb, for interaction with Helicobacter  pylori vacuolating cytotoxin. (2004) J. Biol. Chem. 279: 51013-51021
  18. Isomoto,  H., Mukae, H., Ishimoto, H., Date, Y., Nishi, Y., Inoue, K., Wada,  A., Hirayama, T., Nakazato, M., Kohno S.: Elevated concentrations of a-defensins  in gastric juice of patients with Helicobacter pylori Infection.  (2004) Am. J. Gastroenterol. 99:1916-1923
  19. Harada, K., Ohba, K., Ozaki, S., Isse, K., Hirayama, T., Wada, A., Nakanuma,  Y.: Peptide antibiotic human b-defensin-1 and -2 contribute to antimicrobial  defense of the intrahepatic biliary tree. (2004) Hepatology 40: 925-932
  20. Ogushi, K., Wada, A., Niidome, T., Okuda, T., Llanes, R., Nakayama, M.,  Nishi, Y., Kurazono, H., Smith, K.D., Aderem, A., Moss, J., Hirayama T.:Gangliosides  act as co-receptors for Salmonella enteritidis FliC and promote  FliC-induction of human b-defensin-2 expression in Caco-2 cells. (2004)  J. Biol. Chem.279:12213-12219
  21. Kawahara, T., Kuwano, Y., Teshima-Kondo, S., Takeya, R., Sumimoto, H.,  Kishi, K., Tsunawaki, S., Hirayama, T., Rokutan, K.: Role of nicotinamide  adenine dinucleotide phosphate oxidase 1 in oxidative burst response to toll-like  receptor 5 signaling in large intestinal epithelial cells. (2004) J. Immunol.  172, 3051-3058
  22. Nakayama, M., Kimura, M., Wada, A., Yahiro, K., Ogushi, K., Niidome, T.,  Fujikawa, A., Shirasaka, D., Aoyama, N., Kurazono, H., Noda, M., Moss,  J., Hirayama, T.: Helicobacter pylori VacA activates the p38/ATF-2-mediated  signal pathway in AZ-521 cells. (2004) J. Biol. Chem. 279,7024-7028
  23. Mori, N., Krensky, A.M., Geleziunas, R., Wada, A., Hirayama, T., Sasakawa,  C., Yamamoto, N.: Helicobacter pylori induces RANTES through activation  of NF-kappa B.  Infect Immun. (2003) 71:3748-3756
  24. Suzuki, J., Ohnishi, H., Wada, A., Hirayama, T., Ohno, H., Ueda,. N, Yasuda,  H., Iiri, T., Wada, Y., Futai, M., Mashima, H.: Involvement of syntaxin  7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced  cytotoxin VacA. J. Biol. Chem. (2003) 278:25585-25590
  25. Mori, N., Sato, H., Hayashibara, T., Senba, M., Geleziunas, R., Wada,  A., Hirayama, T., Yamamoto, N.: Helicobacter pylori induces matrix  metalloproteinase-9 through activation of nuclear factor kappaB. Gastroenterology  (2003);124:983-992
  26. Yahiro, K., Wada, A., Nakayama, M., Kimura, T., Ogushi, K., Niidome, T.,  Aoyagi, H., Yoshino, K.I., Yonezawa, K., Moss, J., Hirayama, T.: Protein  tyrosine phosphatase a, RPTPa, is a Helicobacter pylori VacA receptor.  (2003) J. Biol. Chem. 278:19183-19189
  27. Fujikawa, A., Shirasaka, D., Yamamoto, S., Ota, H., Yahiro, K., Fukada,  M., Shintani, T., Wada, A., Aoyama, N., Hirayama, T., Fukamachi, H., Noda,  M.: Mice deficient in protein tyrosine phosphatase receptor type Z are  resistant to gastric ulcer induction by VacA of Helicobacter pylori. (2003)  Nat. Genet.  33:375-381
  28. Kimura, T., Wada, A., Nakayama, M., Ogushi, K., Nishi, Y., de Guzman,  B.B., Moss, J., Hirayama, T.: High molecuolar weight factor in FCS inhibits Helicobacter  pylori VacA-binding to its receptor, RPTPb, on AZ-521. (2003) Microbiol.  Immnol. 47:105-107
  29. Shirasaka, D., Aoyama, N., Sakashita, M., Kuroda, K., Maekawa, S., Wambura,  C.M., Miyamoto, M., Tamura, T., Yahiro, K., Wada, A., Kurazono, H., Hirayama,  T., Kasuga, M.: Relationship between gastric ulcer and Helicobacter pylori VacA  detected in gastric juice using bead-ELISA method (2002) Helicobacter 7:281-286
  30. Paone G, Wada A, Stevens LA, Matin A, Hirayama T, Levine RL, Moss J.:  ADP ribosylation of human neutrophil peptide-1 regulates its biological  properties. (2002) Proc. Natl. Acad. Sci. USA. 99:8231-8235.
  31. Ohsaki M,  Okuda T, Wada A,  Hirayama T, Niidome T, Aoyagi H,  :In Vitro Gene Transfection Using Dendritic Poly(L-Lysine). (2002)  Bioconjugate  Chem. 13:510-517
  32. Supajatura, V., Ushio, H., Wada, A., Yahiro, K., Okumura, K., Ogawa, H.,  Hirayama, T., Ra, C.: VacA, a vacuolating cytotoxin of Helicobacter pylori directly  activates mast cells for migration and production of pro-inflammatory cytokines.  (2002) J. Immunology 22:2603-2606